Lefu Cushing e - lefu le pituitary hyperfunction

Cushing oa Mafu kapa Cushing e - lefu le eo ho bakoa ke ho tlōla le hypothalamus, pituitary le litsoelesa adrenal le ntshetsopele ya diso rarahaneng. Lefu lena le ile la pele o ile a hlalosa ka ho H. Cushing ka 1924, 'me ka 1932 Cushing amahanngoa ntshetsopeleng lona le pituitary adenoma.

Lisosa tsa lefu Cushing e ke adenoma basophilic ea pituitary anterior lobe kapa ho eketseha palo ea lisele tse basophilic pituitary. Liphetoho tsena li ka 'na fella ka boko sithabetsang le ho sithabela kelellong, ho ruruha ha boko, mafu endocrine.

Motheong oa lefu lena le - hyperproduction ea pituitary adrenocorticotrophic hormone, e leng e etsa hore ho eketseha ha ho tswakana ea cortisol ke litsoelesa le adrenal.

lefu Cushing e - ea tleleniki setshwantsho

Lefu lena le hlaha butle-butle. Bakuli ba tletleba la bofokoli kakaretso, ho otsela, ho hloka thahasello, a tsoela pele ho botenya. Botenya ama haholo-holo halofo e ka holimo ea 'mele. Ka lebaka leo, bakuli ba thehoa khoeli sefahleho, mahetleng feletseng, letheka, le disproportionately masesaane, forearms atrophic le shins. Ho omile le gommage ea letlalo, 'mele le moriri ka mohlala motona ka basali, le ho lahleheloa ha e tsoa hong ea moriri ka hlooho, ho feminization ba batho. Ka letlalo la mpa ea, mahetleng, letsoele hlaha dystrophic metopa lohle la bo bofubelu-pherese mmala. Ha nako e ntse, ho ntshetsa pele ho fokola mesifa maoto le matsoho, fokotswa matla a bona. Ho ntshetsa pele kgatelelo ya madi le lefu renal, mathata bokong 'me atherosclerosis.

lefu Cushing e isang ho tlōla metabolism matsoai, le ka lebaka la e le tsoelo-pele ea osteoporosis. Ka lebaka osteoporosis ba mahae le petetswa metso methapo ea kutlo, ho na le e matla bohloko lipheletsong le, lesapo la mokokotlo, qapa kotlobane lesapo la mokokotlo thoracic le sebopeho sa kyphosis, pathological fractures. k'halsiamo le k'holeseterole e ka eketseha ho mali. Thibang ho absorption ea tsoekere, ho fellang ka ho ntshetsa pele le lefu la tsoekere. Eketseha tšekamelo ea ho ba le ntshetse pele ho tsoa mali, hampe folisa maqeba. Bakuli ba tletleba ba ho se sebetse ho kopanela liphate, fokotseha libido le potency, hlahella mafu matsatsing. Khoneha neuroses, ho tepella maikutlo, hypochondria, psychosis.

Ba pelo develops hypertrophy tsa letšehali ventricular tachycardia, bolaeang mahareng kgatelelo ya madi. Ha ho ithuta liphio a senola proteinuria, fokotseha sekhahla glomerular karaoke set le renal phallo ea mali. Mohlomong u ka ntshetsopele ya renal scarring leqeme mosebetsi wa litho tsena. Ba bang bakuli ba ka majoe a liphio a lemoha.

phumano ya lefu lena

lefu Cushing bo fumanoa holding lehata: x-ray ka ithuta tshusumetso ya Sella, ea computed tomography ea lehata, 'me litsoelesa adrenal, lithuto tsa vascular - angiography. liteko laboratori ea fumana hore na boemo ba hormone cortisol maling le ka tjhelete e ya corticosteroid ka moroto wa.

lefu Cushing e - Phekolo

Khetha kalafo haholo itšetlehile ka sesosa sa lefu lena le le ho tiea tsa liponahatso tsa tleleniki ea lefu lena.

Ka mekhahlelo e mathoasong a laetsoeng meriana lithethefatsi tse fokotsa secretion ea li-hormone adrenocorticotropic le corticosteroids. Sebelisoa e le lithethefatsi antihypertensive, bontshang matshwao phekolo. Mokhoa oa phekolo ea meriana le teng ho fihlela ho likhoeli tse robeli. Haeba ha ho na e le hantle, liforomo tse matla tsa lefu lena le, ho laela motswako phekolo e entsoeng ka phekolo mahlaseli le ho buoa (tlosoe pituitary kapa adrenalectomy).