Triptans bakeng migraine. Triptans: lithethefatsi litheko

Migraine - le bothata bakeng sa bakuli ba bangata. Hoo e ka bang mong le e mong bonyane hang ka bohloko liphihlelo tse bophelong hloohoaneng. E le busa, ba ile ba ba tsamaea le molikoalikoane, ho nyekoa ke pelo, ho hlatsa, hammoho le shoohlo, tingling le bofokoli ea lipheletsong, photo- le phonophobia. Ka mor'a tlhaselo e, bakuli ba tletleba ba mokhathala, lethargy 'me ho otsela. Ka linako tse ling ho na le Maemong a ha lefu lena le joalo matha, e ka feela thusa mokuli triptans hlooho. Re lokela ho hlokomela hore migraine - lefu la basali, ha ba ntse ba na le ho feta bonolo hore bolwetse joalo, ho feta banna ba. Hoo e ka bang 10-18% ea batho ba baholo na le boloetse ba migraine.

The bothata ba ho tšoaroa ke hlooho tloaelehileng ho mong le e mong

batho ba bangata ha ba batla thuso ho tswa ho lefapha la bongaka le ba tšoanelehang 'me o leka ho sebetsana ka katleho le le lefu lena, ha a ntse a noa analgesics. Ha ho potang hore tsela eo motho joalo ha e thusa, empa feela totisa boloetse bona. Tshebediso sa laoleheng ea analgesics ka etsa hore tsoelo-pele ea lithethefatsi ka lebaka la ho tšoaroa ke hlooho le sa foleng. Ka hona, ha ho makatse hore ho na le palo e khōlō ea lipotso mabapi le ea mofuta ofe hlooho lipilisi - e atlehang ka ho fetisisa.

Ka ho feletseng phekola migraine ke ke ha khoneha, empa ho ntlafatsa boleng ba bophelo ka etsahala le lihlahisoa khethehileng, e leng ba khethiloe ke boloetse ba methapo e. Ho na le hona joale e tsejoang e le palo e khōlō ea migraine tse lekaneng e atlehang nakong ea tlhaselo e, 'me ka nako interictal. Ka mor'a moo, ka ho hlahlobisisa lithethefatsi bakeng sa migraine: lethathamo la mehlodi ya le a hlobaetsang le tlhaselo ntle phekolo. E paka hore triptans - lithethefatsi atlehang ka ho fetisisa ea ho felisa hlooho e opang haholo. Le lithethefatsi prophylactic ba abeloa lihlopha tse latelang:

• β-blockers;
• antidepressants;
• antiemetic;
• metsi-qhibilihang ka har'a vithamine B;
• k'halsiamo blockers;
• anticonvulsants.

Amohela Ranked tsohle tse ka holimo e le meriana lokela ho thonya motho ba tšoanelehang.

Hobaneng ho ba le hlooho e opang?

Pele u utloisise hore na ho etsa lintho ka triptans tloha tšoaroa ke hlooho, theko ea eona e itšetlehile ka hore moetsi, ho ke ke ho hlokahala hore ba utloisise mochine oa bolwetse le. Hlooho e develops e loketseng ho tlhotlheletso ya receptors tsa meninges le lijana bokong. Ha khatello ea kelello ka tsela e feteletseng le e feletseng ea methapo ea mali, haholo-holo methapong, teng ka boemo hypotonic develops utloe bohloko bo boholo, e leng e ka felisoa feela ka meriana e khethehileng. Bafuputsi ba bangata ba neng ba ba khella bakeng sa nako e telele, a lokisetsa hore ho phekola migraine, ba fihletse qeto ea hore triptans - mokhoa molemo ka ho fetisisa ea ho rarolla bolwetse ena.

thepa triptans

The lithethefatsi ikemiseditse ho narrowing lijana dilated ea boko. Triptans - ya moriana o sebetsang sebakeng sa hae ka khubung le receptors tsa methapo ea kutlo trigeminal, eo le eena ho fokotsa nahanela ya bohloko monyako. Triptans - antimigraine lithethefatsi ea kajeno, eo na le selectivity ena e phahameng le lijana tsa mali a Dura mater (Dura mater encephali) le lijana batlang e le tse sa reng letho le pheriferale le gogoga.

Hlahisa meriana e atleha ho fokotsa bohloko ka boemo ba motheo lesapo la mokokotlo oa methapo ea kutlo trigeminal. Ho phaella ho triptans tsohle ka holimo - lithethefatsi tse ke keng feela fokotsa ditiragalo tsa khutlela mokhoeng lefu, empa hape felisa se amahanngoang liponahatso tsa tleleniki ea eona (mohlala, ho nyekoa ke pelo, ho hlatsa, photophobia, 'me molumo oo).

Melemo e ka sehloohong ea triptans

Tsena thepa diokobatsi ea phahameng lebelo kenyelletsoa sephetho. Ka ho toba le ka halofo ea hora ho na le lipontšo tsa liphello tse ntle tsa lithethefatsi 'meleng oa mokuli. Phello phekolo e hlokomelwa ho pholletsa le tlhaselo migraine. Boholo ba bakuli ba hlooho ha a khutla.

Matsatsing ana, bo-rasaense ba pakile hore le phumano ya precursors tlhaselo lokela hang-hang nka triptans bakeng migraine. Pejana ho moo ho ne ho khopolo hore litlhaselo migraine lokela ho tšoaroa ka mekhahlelo, ho qala ka ba baeti ba fihlelang ho ea meriana e bonolo.

Lithethefatsi bakeng sa migraine: lethathamo la meriana ho fetisisa ratoa

Ka sehlopha triptan ea lithethefatsi e kenyeletsa tse latelang:

• 'Zomig'.
• "Amigrenin".
• "Sumatriptan".
• "Imigran".
• "Relpaks".
• "Trimigren".
• "Sumamigren".
• "Rapimed".
• "Almotriptan".
• "Naramig".
• "Naratriptan."
• "Frovatriptan."
• "Zolmitriptan."

The lithethefatsi bakeng sa e mong le e le mamello e ka 'na ka tieo motho, kahoo e le hore ho etsa bonnete ba ho atleha ha ena kapa tse ling tse meriana, lingaka nkhothaletsa ho leka ho e hapa, bakeng sa litlhaselo tsa migraine tse tharo. Tryptamine sehlopha sa lithethefatsi e tšoauoa ka bioavailability phahameng, ba batlang e le bonolo ho hlōla mali-boko mokoallo, ho molemo ho ka fokotsa litlhaselo tsa migraine, esita le mohato bohloko. Tsena meriana e loketseng ea ho laela ho bakuli ba e leka-lekaneng ho e matla ho tiea lefu.

kopo Notes

Haholo hangata e re utloa potso e tšoanang: seo hlooho e lipilisi ke ke molemo? lithuto tsa liteko li bontšitse hore ho bolela atlehang ka ho fetisisa ba ho felisa matšoao a migraine ba triptans. Ho molemo ho nka triptans bakeng migraine ha e e iphumanela ho lipontšo pele ea tlhaselo. The lebetsoeng le analgesic le phello 'nile ha hlokomeloa ka lihora tse peli ka mor'a hore moriana. Pele noa moriana, ka hloko bala litaelo le ngakeng. Ho bohlokwa haholo ho thibela lithethefatsi overdose. Triptans bakeng migraine e sa kgothaletswa ho sebelisa hammoho le lithibela-mafu, antifungal, antiviral mahlahana a, hammoho le ba nang le antidepressants.

Ho fihlela sephetho lakatsa, bakuli ba tlameha ho khomarela melao e tataisang e latelang bakeng sa ho fumana triptans:

• le bonolo ho hlooho e leka-lekaneng nka 1 Letlapa (kapa spray mong lethal dose);
• lethal dose ea bobeli e nkiloeng sa pele ho moo ho feta 2 chasa;
• motšehare ha ba nke tekanyetso tse fetang tse peli;
• triptans ha ba kgothaletswa ho nka matsatsi a fetang a mabeli ka beke.

Nakong ea kalafo ya dijo tsa hao li lokela ho qheleloa ka thōko tiraminsoderzhaschie Products:

• cocoa;
• tsokolate;
• linaoa;
• mahe;
• celery;
• dilamunu;
• a tlatsana le phepo e nepahetseng;
• chisi;
• tamati;
• linate;
• lino tse tahang.

E mong o lokela ho se ke ua ja lijo tse batang.

Ka ketsahalo ea migraine triptane, theko ea eona e tla bontša ka tlaase mona, e ka boela ea sebelisoa le lithethefatsi tse ling, tse kang metoclopramide kapa domperidone.

litla-morao

Ha overdose ea lithethefatsi, bakuli ba tobana le liphephetso tse latelang:

• ho tsekela;
• anaphylactic makala;
• tightness;
• ho nyekoa ke pelo;
• boikutlo ba ho ba mofuthu;
• infarction ea spleen, mala;
• ho hlatsa;
• ommeng molomo;
• myalgia;
• bohloko mpeng;
• otsela;
• tukang a ikutloa joang ka letlalo;
• Angioedema;
• tachycardia;
• hives;
• polyuria;
• mesifa bofokoli;
• fokotseha a lebisa tlhokomelo;
• meferefere kutlo;
• haemorrhagic letšollo;
• kgafetsa ho ntša metsi;
• gogoga vasospasm.

Ho sa tsotellehe sena sohle, triptans bakeng migraine - ya meriana ka potlako-ho nka bohato. Sehlooho litekanyetso li behoa 'me maqhubu a ea etellang lithethefatsi kotsing ea litla-morao e fokolang haholo. Ka kakaretso, triptans tsohle lumelloa ke 'mele ka tsela e tloaelehileng. litla-morao, ha ba hlaha, joale a bontša bonolo le rarolla ka boithatelo ntle kenella bongaka. The drawback o ka sehloohong oa triptans - ena ke theko bona. Ka bomalimabe, ha bakuli bohle ba ka khona ho ea lithethefatsi e joalo.

Contraindications

Triptans bakeng migraine ha ho kgothaletsa ho sebelisa maemong a latelang:

• leqeba;
• angiospastic angina;
• bokhachane;
• cerebrovascular kotsi;
• nakong ea matsoele-ho fepa lesea;
• coagulopathy (mali hoama);
• bocha;
• mafu a ea tsamaiso ea pelo le methapo;
• hypersensitivity ho dintho bioactive tsa thero ea;
• sa laoleheng kgatelelo ya madi;
• arrhythmia;
• sebete le liphio lefu;
• atherosclerosis.

Pele prescribing triptans itseng, ngaka e-ba teng ba lokela ho khetholla lintlha kotsi bakeng sa atherosclerosis. lintlha tsena li akarelletsa tse latelang:

• lefu la tsoekere;
• poso-menopausal basali;
• ho tsuba;
• kgatelelo ya madi;
• botenya;
• boemo bo phahameng ba e sa tloaelehang k'holeseterole mali;
• lilemo tse fetang lilemo tse 40 bakeng sa batho;
• predisposition liphatsa tsa lefutso ho lefu la pelo.

Ba bang bakuli ba ba kotsing e lokela ho fumana lethal dose ea bona ea pele ea tryptamine tlas'a bookameli ba setsebi sa le tlas'a ECG taolo.

Leqheka la ho tšoara migraine

Ho na le melao-motheo ea kakaretso ea phekolo ho phekola mafu a tse loketse maemong a mangata:

• ho hlokahala hore ho qala kalafo ka analgesics kapa tlhakantsuke ya lona (ho akarelletsa le lithethefatsi nonsteroidal-ba khahlanong le a hlabang);
• Ha analgesic sebelisoa ha e fane ka lebaka ntle, ka nako eo ka mor'a metsotso e 45 ba lokela ho nka triptan;
• ha e triptan e bile thuso, tlhaselo e tlang lokela ho sebelisa ea lithethefatsi o mong ho tloha triptanovoy sehlopha;
• le atypical hlooho e ke ho hlokahala hore ho sebelisa batho bao e seng steroidal-ba khahlanong le a hlabang lithethefatsi.

Tšebeliso ea lisebelisoa tsa morao-rao bakeng sa kalafo ya migraine, ba bōptjoa ka lebaka la triptans, ho thusa ho etsa hore bophelo bo be bonolo hore bakuli ba bangata. Se ke la lebala hore ho meriana tsena ka e balletsweng ke ngaka, 'me feela ha tepelletse maikutlong ka. Ho na le maemo ha triptans le analgesics tse ling nonspecific u se ke ua fana ka sephetho batlang 'me ha a felisa bohloko. Tabeng ena, lingaka hangata hlalosa phekolo rarahaneng le meriana anticonvulsant, le beta-blockers. meriana ena kenyeletsa lithethefatsi tse latelang:

• "Penbutolol".
• "Nadolol."
• "Betaxolol."
• "Topiramate".
• "Neurontin."
• "Phenobarbital".
• "Timolol".
• "Propranolol".
• "Labetanol".
• "Bellataminal".
• "Metoprolol".
• "Topamax".
• "Acebutolol".

Tsela ea ho fokotsa ditiragalo tsa litlhaselo tsa?

Ho fokotsa makgetlo a ba bakuli ba migraine tlameha ho khomarela melao e latelang:

• ja kamehla;
• tsa kgetholla ho tloha ho ja lijo tse hao le lino tse tsosang litlhaselo tse (biri, chokolete, chisi, shots, litholoana dilamunu, veine e khubelu e);
• khaotsa ho tsuba;
• jwalo ka ntho e ka etsahalang ho ba ka ntle nako e telele;
• qoba khatello ea kelello;
• Ho ikoetlisa (loketseng - sesa);
• qoba maeto telele ka bese, sekepe, koloi.

Triptans ke hlooho e: theko

Triptans di hlahiswa mefuta e fapaneng litekanyetso li behoa: ditharollo ente, spray nasal, matlapa, rectal suppositories. Ka litsenyehelo tsa ho ba ea lithethefatsi e amang ho lokolloa foromo, litekanyetso li behoa, palo ea lipilisi ka sephutheloana le. Ka lebaka leo, theko ea lithethefatsi tsena li ka fapana ka mefuta e fapaneng ya mefuta e - 150-1500 li-ruble ka pakete.