The rheological thepa mali - ke eng?

Nyenyenyane, o ithuta deformation le phallo litšobotsi tsa continuum ea sebele, e mong oa baemeli ba seo ka sona - maro a batho bao e seng Newtonian le mehaho e tiileng e qamathelang, rheology protrudes. A sehloohong sena a re nahana ka thepa rheological ea mali. Hore na ke eng, e tla ba hlakile.

tlhaloso

A tloaelehileng bao e seng Newtonian mokelikeli - mali. Lero la mali e bitsoa, haeba ho ke ke bosula le bo sa likarolo foromo. Mali serum ke lero la mali, eo ha le na fibrinogen.

Hemorheology kapa rheology, dipaterone phetha molao utolla, ka ho khetheha e le phetoho fizkolloidnye thepa ajoa mali ka lebelo fapaneng le karolong e fapaneng ea bethe sejana. thepa ea eona, boemo ba tshebetso maling, e contractile bokhoni ba pelo ea etsang qeto ea motsamao oa mali 'meleng. Ha lebelo guttate la phallo e nyenyane, likaroloana mali a mahae e tšoanang le ho ea tselaneng ea sejana le mong ho e mong. Tabeng ena, mofuta mekhahlelo ea phallo le ho phalla e bitsoa laminar. ke kahoo seo thepa rheological? Ena - on.

Reynolds Number ke eng?

Tabeng ea eketsa lebelo guttate le feteng ya boleng itseng, a fapaneng bakeng sa lijana tsohle, laminar phallo tla ba vortex, mokhoa o sa laoleheng e bitswang moferefere. Fetoheng molaong lebelo laminar phallo ho moferefere rerang Reynolds palo bakeng sa sejana se mali molao hoo e ka bang 1160. Ho latela linomoro Reynolds loebehlanang ka ba feela le libakeng tseo lijana kgolo branching, hammoho le ka aorta ena. Lijana tse ngata laminar susumeletsa mokelikeli.

Lebelo le ho imeloa kelellong kuta

E seng feela ho bophahamo ba modumo le guttate phallo ea mali lebelo e leng tsa bohlokoa, tse peli entsprechen tse ling tsa bohlokoa khethollang mokhatlo oa ho sekepe: ya lebelo le ho imeloa kelellong beola. Tšoauoa ka gagamalo feto-fetohang a ba qobelle ho nka bohato ka vascular unit trust holim'a ka tataiso bose ho holim'a metsi, lekanngoa ka Pascals kapa dynes / cm, ^2. Sekhahla kuta e lekanngoa ka metsotsoana e bapileng (s-1), 'me e bolela hore boholo ba lebelo ho kretiente pakeng tsa le dikarolo e tšoanang ho mokelikeli ho fallela ka unit trust sebaka se pakeng tsa bona.

Ka seo entsprechen itšetlehile rheological thepa?

The karo-karolelano ea ho imeloa kelellong ho sekhahla kuta rerang ho mali e tiileng e qamathelang, lekanngoa ka mPas. Ka mokelikeli e tiileng e qamathelang kaofela itšetlehile ka kuta sekhahla fapaneng ya 0.1-120 ^s-1. Ha sekhahla kuta> 100 ^s-1, phetoho e tiileng e qamathelang ha e le phatlalatsoe, 'me ka fihla le reiti ea kuta ea 200 ^s-1 ke hoo e ka bang e sa fetohe. Boleng lekanngoa ka lebelo le phahameng kuta, bitsoa asymptotic. Mabaka a ka sehloohong e amang e tiileng e qamathelang - seleng deformability likarolo, hematocrit le aggregation. 'Me e fanoa e le hantle hore lisele tse khubelu tsa mali a bapisoa le liplatelete le leukocytes tse ling tse ngata ba haholo-holo hore na lisele tse khubelu. Sena se bonahala ka thepa rheological ea mali.

lintlha e tiileng e qamathelang

The ntho ea bohlokoa ka ho fetisisa beha e tiileng e qamathelang - molumo mahloriso tsa lisele tse khubelu tsa mali, bophahamo ba modumo bona karolelano le dikahare, sena o bitsoa hematocrit. Ke hoo e ka bang 0.4-0.5 k / k le e laolwang ke centrifugation tsa disampole mali. A lero la mali - e mokelikeli Newtonian, le e tiileng e qamathelang ya eo rerang sebōpeho sa liprotheine, 'me e itšetlehile ka mocheso. E tiileng e qamathelang ke bohlokoa ka ho fetisisa e le hantle globulin le fibrinogen. Bafuputsi ba bang ba lumela hore ntho ea bohlokoa ho feta e isang ho fetola lero la mali e tiileng e qamathelang - ke karo-karolelano ea liprotheine: albumin / fibrinogen albumin / globulin. Eketseha aggregation ho etsahala ha e behilweng ke boitšoaro ba batho bao e seng Newtonian mali kaofela, sephetho le erythrocyte aggregation. Fisioloji erythrocyte aggregation ke tshebetso reversible. Ke hore na ke eng - the thepa rheological ea mali.

Thuto erythrocytes aggregates itšetlehile ka lintho tse phetha molao, hemodynamic, electrostatic, lero la mali 'me ba bang. Mehleng ena, ho na le likhopolo tse 'maloa tse hlalosang hore na mochine ea erythrocyte aggregation. Tsebahalang kajeno ho hlaola khopolo ea mochine ka eo marokho tsa protheine krupnomolekulyarnyh, fibrinogen Y-globulin ba adsorbed holim'a lisele tse khubelu tsa mali. Matla a aggregation letlooa - phapang pakeng tsa lebotho la kuta (bakang disaggregation), mokato oa erythrocytes electrostatic repulsion, tse hlonamisitsoe qosoa, le matla a ka marokho le. The mochine le boikarabelo ba ho fixation tsa macromolecules hlonamisitsoe qosoa ka lisele tse khubelu tsa mali, ke hore,, Y-globulin, fibrinogen e e-s'o e hlakileng haholo. Re teng ka maikutlo a hore limolek'hule ho khomarela ka lebaka la ba qhalakanyetsa ho makhotla a Van der mabotho Waals, 'me litlamo tsa hydrogen fokola.

thuso hore ho hlahloba ho thepa rheological mali?

Ka lebaka le itseng, ho na le ke aggregation tsa lisele tse khubelu tsa mali?

Tlhaloso ea aggregation platelet hape akh'aonto depletion, ho hloka liprotheine phahameng-limolek'hule haufi le erythrocytes sa, 'me ka hona ho bonahala eka khatello itšoara joang, tse tšoanang tsa tlhaho ho khatello osmotic ya tharollo macromolecular, ea isang ho le convergence ea likaroloana le emisitswe. Ho phaella moo, ho na le khopolo e kopanya aggregation tsa lisele tse khubelu tsa mali ho tswa lintlha erythrocyte isang ho phokotso ya bokgoni ba zeta le phetoho e metabolism mme sebopeho sa lisele tse khubelu tsa mali.

Ka lebaka la kamano ea e tiileng e qamathelang le erythrocyte aggregation matla a ho hlahloba mali rheology me haholo-holo mokhatlo oa likepe tsa lona, re lokela ho tsamaisa and analysis akaretsang ya data tshebetso. E 'ngoe ea mekhoa e atileng ka ho fetisisa le ho hang-hang a fumaneha bakeng sa ho lekanya aggregation - e le tekolo ya erythrocyte sekhahla sedimentation. Leha ho le joalo, phetolelo ea tloaelehileng ea teko eo, tlhahisoleseding e nyenyane, hobane ha e hlokomele litšobotsi rheological.

mekhoa ea go lekanya

Ho ea ka lithuto tsa mali litšobotsi tse rheological le lintlha tse ba amang, re ka fihlela qeto ea hore tekolo ya thepa rheological mali e ama boemo aggregation. Matsatsing ana, bafuputsi ba lefa tlhokomelo e eketsehileng ho ithuta thepa microrheological mokelikeli ona, empa hape le ho tshwaneleha le viscometry se lahlehile. mekhoa ea motheo bakeng sa ho lekanya thepa mali ka aroloa lihlopha tse peli: le khatello ea tšimo 'me khatello homogeneous - konusploskost, chitja, cylindrical le rheometers tse ling le geometries fapaneng likarolo sebetsa; le mefuta ea tšimo 'me e hatisa batlang inhomogeneous - ka molao-motheo oa ngoliso ea mexri, motlakase, ho thothomela ho phetha molao feela, lisebelisoa tse sebetsang ka Stokes mokhoa, capillary viscometers. Kahoo lekanya thepa rheological mali, lero la mali le serum.

Tse peli tse mefuta e sa viscometers

hona joale ho atile ho fetisisa nang le mefuta e 'meli ea viscometers: rotational le capillary. Viscometers ba a boela a sebelisa, e le cylindara e ka hare e leng sa phaphamala ka mokelikeli eo ho lekoa. Re kopanela ka mafolofolo diphetolo tse fapa-fapaneng rotational rheometer.

bofello

Ho lokela ho hlokomeloe hore tsoelo-pele ea bohlokoa theknoloji rheological feela ho re nolofalletsa ho ithuta ka skeletal le biophysical thepa mali ho matha mikroregulyatsiey ka tshilong ya dijo le mafu hemodynamic. Leha ho le joalo, hona joale ka motsotsoana ntshetsopele ya mekhoa bakeng sa ho hlahloba hemorheology, e neng e tla e hlaphohileng bonahatsa aggregation le thepa rheological a mangata Newtonian.