"Teopeka" (300 mg,): litaelo bakeng sa ho sebelisoa, ho bonahala, moetsi

Batho ba nang le asma e, oa tseba hore nako ea bohlokoa hakae ho thusa ka bronchospasm. Ka linako tse ling bohato nepahetseng boemong boo thata ka pholosa bophelo. A karolo ea bohlokoa ka ho batho ba tsoang mathata matšoafo bapala bronchodilators.

Tlhaloso ya ba lokisetsa ho ea

"Teopeka" (300 mg,), litaelo bakeng sa tšebeliso eo e bontša ka pampiri ena ke matlapa tšoeu ploskotsilindricheskoy sebopeho chitja, tse tletseng batho paka ea moeli. Ba ka sehloohong a sebetsang a motsoako oa lithethefatsi ke theophylline. mahloriso lona ka letlapa le 'ngoe ea ba lokisetsa ho ea ka foromo ena e 300 mg,.

Joang moriana oo?

Ke ketso tsa lona diokobatsi tsa theophylline, e leng sehlahisoa sa purine, o na le phello inhibiting ka phosphodiesterase ena. The a sebetsang a motsoako oa litene moriana itseng purine receptors, di hlohleletsago Camp bokella ka didepo dinama tse nyenyane tse, lowers le bokhoni ba mesifa boreleli dinama tse nyenyane tse ho konteraka, fokotsa palo ea bolokolohi k'halsiamo ions, eo fallela ka lera la seleng.

Tšoauoa phatlalatsa vasodilating phello e baeti ba fihlelang ho "teopeka" ho lokisetsa (300 mg,). Litaelo bakeng sa ho sebelisoa e hlalosa thepa e le tšusumetso e ka methapo ea mali pheriferale. Theophylline eketsa phallo ea mali ka tsamaiso ea renal, khothalletsa batho boikhathollo tsa boreleli lijana bronchial mesifa le mali. Hape, bohato ba karolo a sebetsang a e tšoauoa ka diuretic e le bonolo. Theophylline thibela ho lokolloa ha dintho kena le ho tsoa, susumelletsang motho e-ba le karabelo alejiki hammoho le eketsa botsitso ba lera la palo seleng. Ha mokuli hypokalemia a sebetsang a ntho lomahantse meno ventilation.

Theophylline thusa normalize ea ka tšebetso ea ho hema, activating le setsi sa lekanang e bokong, sephetho le ka molemo mali oksijene ho tlala, ho decreases tsa mahloriso tsa carbon dioxide. Lithethefatsi "teopeka" di hlohleletsago le diaphragm, a etsa hore ho khaola. E boetse e eketsa boleng ba pontshi tsa mosebetsi mucociliary rengwa lomahantse meno ho hema le intercostal mesifa.

Theophylline isang ho tloaelehile mali mikrotsirkullyatsiyu fokotsa thrombus sebopeho, le palokatiso patelang itseng le felisa aggregation ea lisele platelet. lithethefatsi hape ntlafatsa phallo ea boleng mali, eketsa ho hanyetsa deforming erythrocytes lintlha.

"Teopeka" (300 mg,), ka tsela eo ho fokotsa khatello ea palo yohle e ajoa ka likopi methapo, 'me hape ho fokotsa ho hanyetsa tsamaisong methapo vascular. Ka lebaka leo, le molumo oa integuments letlalo, a liphio le boko decreases. Ka lebaka la ho amohela theophylline tšoauoa tlhotlheletso ya phallo gogoga mali, e ile ea eketseha mosebetsi cardiac, keketseho ea myocardial lisele tse hlollang le hloka oksijene, quickens le pulse length, matla a pelehi pelo e ile ea eketseha.

Pharmacokinetics le pharmacodynamics ya moriana

Ka mor'a hore mokuli a ikutloe a nka pilisi ka theophylline, ntho e ka ho feletseng ananelang pampitšaneng gastrointestinal. Lijo seno o na le phello e tekanyo ea absorption ea lithethefatsi, empa tekanyo ea absorption le rengwa ntse e sa fetohe. Ho tloha ka lero la mali protheine tlama 40% ya ntho mafolofolo. Theophylline metabolism le hlaha ka sebete ke cytochrome P450.

Excretion tsa metabolites hlahisoa mofuta o le mafolo-folo ka tsela liphio, empa 10% ea lithethefatsi e felisoa foromo ka eona qalong. Ba bang lintlha ba le phello e bohlokoa ka metabolism tsa theophylline. Ho tsuba, ho noa meriana e itseng, mekhoa le motsoako, comorbidities, ea lilemo li, ba khona ho etsa liphetoho ho phapanyetsano ea ntho mafolofolo 'mele oa motho. Fokotsa rengwa theophylline e hlokometse ka matšoafo edema, lefu la sebete, COPD, 'me ka ha pelo.

Ke mang ea ka amohela sesebelisoa see?

Ho na le maemo a itseng oo "teopeka" (300 mg,). Litaelo bakeng sa ho sebelisoa e hlalosa mafu a latelang:

• la bronchitis obstructive foromo foleng;
• robala apnea;
• emphysema;
• asma;
• kgatelelo ya madi methapo;
• pelo ea methapo.

Hape, lithethefatsi "teopeka" poeletsotlaleho positive, e leng e ka sebediswa hammoho le lithethefatsi tse ling ea ho phekola ba renal edema tlhaho. Bakuli ba hlokomela bokgoni phahameng oa sesebelisoa sa le kamogelo lona bakeng sa kalafo ya mafu a ea tsamaiso ea ho hema.

Contraindications

Leha ho le joalo, lithethefatsi ena ka sebelisoa ha mong le e mong, ka lebaka la ho ba teng ha a 'maloa a ka litemoso tse tsoang ho chelete eo. "Teopeka" contraindications ke tse latelang:

• hemorrhagic leqeba mofuta;
• sethoathoa;
• tsoa mali ho tswa ho pampitšana gastrointestinal historing;
• seso sebopeho ka litho tsa tshilong ya dijo;
• tachycardia phahameng severities;
• kgatelelo ya madi kapa hypotension;
• hypersensitivity;
• gastritis, a tsamaea le acidity phahameng;
• Bana ho fihlela ho lilemo tse 12.

Ka ho ba teng ha bonyane e mong oa syndromes tsena kapa maemo a sa theophylline lithethefatsi lokela ho lahla

litla-morao

Ho na le ke haholo sehlopha se seholo sa ditlamorao ho etsa "teopeka" ho lokisetsa (300 mg,). Litaelo bakeng sa ho sebelisoa tsa likarolo tsa bona ka liponahatso systemic:

• mafu a ea tsamaiso ea methapo ea kutlo: tšoaroa ke hlooho, molikoalikoane, ho robala meferefere, restlessness, e ile ea eketseha ho tšoenyeha le ho teneha, ke thothomele;
• ho se sebetse ba pelo 'me mali a lijana: tachycardia, arrhythmia, hypotension, e ile ea eketseha maqhubu la litlhaselo angina, angina bohata;
• tlōlo gastrointestinal tloaelehile tshebetsong: ho nyekeloa ke pelo, gastralgia, ho hlatsa, lesokolla, reflux, liso tsa ka maleng exacerbation, letšollo, fokotseha takatso ea lijo;
• liponahatso tsa kulisa: letlalo lekhopho, feberu, ho hlohlona;
• har'a liketsahalo tse ling tse bohloko ho etsa lithethefatsi li ne li re: tachypnea, albuminuria, e ile ea eketseha diuresis, bohloko ka sternum, hematuria, Flushing, e ile ea eketseha ho fufuleloa, gipoglekemiya.

Ka tloaelo ho, ka khalemelo ea lethal dose ho fokotseha litla-morao e fokotsehile kapa khaotsa ka ho feletseng.

Tsela ea ho nka lithethefatsi?

Ho bolela ho tloha la bronchitis, tse kang "teopeka" ba abeloa feela ke ngaka ho ba teng le litekanyetso li behoa bona e kgethile motheong motho ka mong. Ka karolelano letsatsi le letsatsi Nome lekana 400 mg, theophylline. Ha mokuli jarelang lithethefatsi hantle, ka nako eo ka mor'a matsatsi a 2-3 ho tloha lethal dose ya pele ya meriana, molumo eketseha ka 25% le ka ho eketsehileng ka ho ba masene le ngaka.

Holim 'a fumana ho bolela ho tloha la bronchitis "teopeka" ka lethal dose ea letsatsi le letsatsi ka tlase ho 900 mg, theophylline dikahare taolo ha hlokahala maling mokuli. Ha o hlahloba ponahalo ea botahoa, le tlhokahalo e potlakileng ho theha e laola boemo ba ho tsepamisa mohopolo oa ka sehloohong a sebetsang a motsoako maling. Libaka tse Hloahloa tsa nkoa litsupa micrograms 10-20 ka di ml. Ha theophylline dikahare mali a mokuli e phahame ho feta e tloaelehileng, ba ile ba hlokomela ntshetsopeleng ya a halefe. Tabeng ena e ho hlokahala hore ho fokotsa litekanyetso li behoa ea ea lithethefatsi, 'me ba le phello e phekolo e tla fokola.

Na ho na le ba le overdose?

Bronchodilators kang "teopeka" ho ka etsa hore maloetse a tebileng ea 'mele ka ketsahalo ea overdose. Ha hantle matched sekhahla letsatsi le letsatsi ka mokhoa fumana matšoao a latelang a ka hlaha:

• fokotseha takatso ea lijo;
• lefu la ho hlobaela;
• letšollo;
• ventricular arrhythmias sebopeho;
• tachycardia;
• tsoa mali ea tsamaiso tshilong ya dijo;
• tachypnea;
• tremor;
• tšoenyeha;
• e phallang oa letlalo ;
• eketseha excitability;
• tšaba khanya;
• ho hlatsa mali.

E boetse e ka ba le chefo e matla, e leng se bontšang oona ka matšoao a latelang:

• ketsahalo ea sethoathoa tsoeroe ke sethoathoa;
• hypokalemia;
• renal ho hloleha, myoglobinuria;
• hypotension;
• pherekano;
• hyperglycemia;
• metaboliki acidosis.

Seo a ka se etsa tabeng ena?

Haeba ho na le ke bopaki ba hore matšoao kapa belaelloa ka hore ba lokela ho etsa lavage gastric, fana ka chelators mamello, laxatives, lithethefatsi, hammoho le ho hlophisa diuresis plasmasorption, hemodialysis le hemosorption. Ha mokuli a e na le sethoathoa, ba ntan'o e kgothaletswa ho kenyelletsa phekolo oksijene le intravenous "Diazepam" tse tla re thusa ho tsela e atlehang ea tšoara ba inkela ka mahahapa. Tabeng ea ho nyekoa ke pelo le bitsoa le ho hlatsa lokela thonya intravenous "betamethasone" lithethefatsi le "Metaklopromida".

Seo meriana ke ke ho kopantswe "teopeka"?

Bronchodilators kang "teopeka 'ha aa lokela ho nka hammoho le macrolide-lithibela-mafu" Allopurinol "," cimetidine "," Lincomycin "," isoprenaline ", hammoho le lithibela-pelehi molomo hobane lithethefatsi tsena li ka thusa ho fokotsa rengwa theophylline.

E sa kgothaletswa ho kopana ja tsa beta-blockers, haholo-holo bao e seng khetha, le lithethefatsi "teopeka", ho tloha e ka hlahisa bronchial constriction le fokotseha bronchodilator phello ea theophylline.

Ha "teopeka" sebelisoa hammoho le "Furosemide" caffeine le lintho tse ling hore a susumetse beta-2 adrenergic receptors, mosebetsi oa karolo e ikhethang e haholo e ile ea eketseha. Ha ho kopantswe le theophylline "Aminoglutitemidom", le lintho tse bonahalang ea pele o qala ho mafolofolo excreted ho tloha 'mele le marotholi a lona bokgoni.

"Acyclovir o" khona ho eketsa mahloriso a ka sehloohong a sebetsang a motsoako "teopeka" le eketsa liphello tse fosahetseng tsa baeti ba fihlelang ho sona. liketsahalo tsa tšoanang le ba o ile a re ha sebedisana tsamaisoa le lithethefatsi theophylline "Dialteazem", "Felodipine" "Verapamil", "Nefedipin". meriana tsena u se ke ua fetola bronchodilator e le hantle, leha ho le joalo, ho ba le mamello ka ba le matšoao a itšoare ka e bohloko kapa overdose.

Ntho "Disulfiram" ea nang le bokhoni ba ho eketsa theophylline mali ho litsupa mahlonoko tseo ho leng kotsi chefo lethopa. "Propranolol", ka lehlakoreng le leng, ho fokotsa "teopeka" rengwa tsa ntho mafolofolo. Mahloriso tsa theophylline e ile ea eketseha ka somestnom baeti ba fihlelang ho sona ka "enoxacin" le fluoroquinolones. Ha phekolo theophylline decreases le ka bokgoni ba ho letsoai lithium.

Ha ho kopantswe kalafo le "pentobarbital", "Carbamazepine", "Isoniazid", "rifamycins", "sulfinpyrazone" eketsehileng rengwa "teopeka" le ho fokotsa katleho ea eona. Ha concomitantly le theophylline "phenytoin" ho na le bobeli thibelo ea karolo ka mafolofolo mali oa mokuli.

tataiso ena ke ea bohlokoa haholo-holo, hlokomoloha bona e tletse lintho tse ngata le mathata a bophelo bo botle. Ka hona, pele u nka "teopeka", bala litaelo ka hloko. 'Me haeba u ba ntse ba tšoaroa ka eona bakeng sa e' ngoe ea meriana tse ka holimo, batla keletso ho ngaka ea hao.

Tsela ea ho reka lithethefatsi le kamoo lithethefatsi Ke habohlokoa?

Ka lebaka la contraindications ho tebileng 'me liphello tsa lithethefatsi ena, "teopeka" lokolloa ka na bapharmasi feela ke lengolo la ngaka.

Lithethefatsi "teopeka" theko ke karolelano e Russia ke li-ruble 160, fanoa ka na bapharmasi ke bahlahisi tse sa tšoaneng. mefuta e 'ngoe - the pheko bakeng sa "Borschagovsky CPP SPC" Lik'hamphani Seukraine meriana. theko ea eona e 155 li-ruble. tlhahiso ea Serussia ea "teopeka" lithethefatsi, 300 mg, e phethile ka likhoebo tsa JSC "meriana khoebo" le "Valens". lithethefatsi tsena li ka ja chelete 290 li-ruble 'me 190 li-ruble ho latellana.

Ka kakaretso, lithethefatsi "teopeka", theko e amohelehang, nkoa moriana ka theko e tlaase bakeng sa ba bangata ba baahi ba rōna. Ha ho bapisoa le counterparts European sesebelisoa sena ke theko e tlaase haholo. Russia tlhahiso ea "teopeka" lithethefatsi o ile a theko e tlaase.

Lemosa ha ho noa meriana

Ha fumana "teopeka" lithethefatsi, ulasan pelanggan tsa tsona li ntle, lokela ho lefa a lebisa tlhokomelo ho tse latelang. Ha Mokuli o gogoga kapa cardiac insufficiency, atherosclerosis, cardiomyopathy, gastrointestinal seso, lefu sebete, kankere ea tšoelesa ea senya, oesophageal reflux, bokhachane, hypothyroidism kapa eketsehileng sekamela ho sethoathoa, le theophylline lithethefatsi lokela ho ho nkoa ka le be hlokolosi.

Bana ba ka tlaase le lilemo li 12 'me bakuli ba baholo "teopeka" a lokisetsa ka seoelo.

Mohlomong tsa mefuta rectal ea lithethefatsi, empa ba lokela ho sebelisoa ka masene ho pathologies tsa rectum le letšollo lefu. Bakuli ba lemalla ho tsuba ntlha theola phello ea kalafo "teopeka".

Nkoa inadmissible kopanetsoeng kalafo theophylline le xanthine derivatives. Ha mokuli a e seng a hōlile 'nileng a bonahatsa mafu pataganeng, tšoaetso ea bongata ba kokwanahloko, lefu sebete, likepe pelo le mali, ngaka e ke ho hlokahala hore ho ho lokisa lethal dose ea meriana.

Nka nka lithethefatsi ho bakhachane?

Mosali e mong oa moimana ea moriana o e bontšoa ho ba teng ha ho bonahala haholo ho tloha theophylline ke khona ho phunyeletse e placenta. Ha baeti ba fihlelang ho "teopeka" bontša mè ea anyesang, ea diabolololo lokela ho khaotsa.

pukwanana ena ke tlhahiso e nolofalitsoeng ea litaelo e feletseng, e leng o khomaretse lithethefatsi "teopeka". E lokela ho a bala ka hloko pele sebelisa. Haeba ho na le ntho e 'ngoe u ferekane kapa ho pelaelo hore a bale ngaka ya hao.