"Ortanol": hore na o thusa, litaelo tsa tšebeliso, ea sebele

ke lithethefatsi "Ortanol" ke efe? From seo thusa moriana? The likarabo tsa lipotso tsena li ka fumanoa mona ka tlase. Ho phaella moo, re hlahisa ka theko ea sehlahisoa se boletseng, contraindications lona, analogs le lokolla foromo.

Mo diphuthelwaneng lithethefatsi, lona sebopeho, tlhaloso, foromo

Ho lokisetsa "Ortanol" e entsoeng ka sebōpeho sa capsules thata boholo № № 1 kapa 2. Hona ho bolela e na le 'mala o mosoeu, hammoho le mantsoe a ngotsoeng ka «OME 20» kapa «OME 40' (ho itšetlehile ka litekanyetso li behoa). capsules dikahare moriana emela Pellets mosehla.

Seo se akarelletsa hore meriana "Ortanol"? Reviews fana ka maikutlo a hore ntho mantlha e nkoa e le omeprazole lithethefatsi. Hape ho na le metsoako e thusang tse kang sodium croscarmellose, le tlaase ka go engwa legatong giproloza, lactose anhydrous, microcrystalline selulose, hypromellose phthalate, povidone, polysorbate 80, talc le dibutyl sebacate.

Sebopeho sa khetla komiki e kenyeletsa: propylene glycol, hypromellose, butanol, carrageenan, ethanol anhydrous, shellac, chloride potassium, isopropanol anhydrous, thaethaniamo dioxide, enke ho ho ingodisa ho le metsi.

Ka pabatsong moriana o "Ortanol" (komiki) kena blister, tsa phutheloa ka mabokose a dikhateboto.

Diokobatsi ketso ya moriana

le "Ortanol" (ho tloha ho se thusa moriana ona, u tla ithuta ka tlase) ke eng? Ho ea ka litaelo tseo, ka ea lithethefatsi ke sesitisa ba proton e pompo. E ho fokotsa tlhahiso ea asiti, ke hore,, liehisa mosebetsi oa K + -H + -ATPase ka mpeng, kapa ho ena le ka lisele tsa hae parietal. Hape ho o beha diboloko ho ba sethaleng e qetellang ea secretion gastric acid e.

Lithethefatsi "Ortanol", theko ea eona e ho tse thathamisitsoeng ka tlaase mona, ke prodrug. sesebelisoa sena e butswe ka mahareng asiti ea tubules (secretory) lisele tse parietal. Ho phaella moo, ho fokotsa khothalelitse le basal secretion sa tsotellehe sebōpeho sa hlasimollang le.

Antisecretory thepa ya moriana o le teng ka hare ho metsotso e 60 pele (palo e kahodimodimo mora dihora tse 2). Thibelo ea 50% ea secretion lebetsoeng le tsoela pele ho pholletsa le letsatsi.

A lethal dose 'ngoe ea moriana e fana ka atlehang le ka potlako hatelloang ea bosiu le motšehare gastric secretion. palo e kahodimodimo ea eona e fihla letsatsi 4th ya kalafo le nyamela ka mor'a matsatsi a mararo ka mor'a kalafo.

Kinetic thepa ea lithethefatsi

Holim 'a ho fumana "Ortanol" ho lokisetsa ho etsa ntho e itseng e phahameng absorption. concentrations tlhōrō ea omeprazole ka mali ba ile ba hlokomela ka mor'a lihora tse 0.5-3. The bioavailability feletseng lithethefatsi ke 30-40%, le mabapi moriana o nang le lihaha-'mele lero la mali - 95%.

Omeprazole metabolism ka sebete le ho theha tse tsheletseng derivatives pharmacologically sa kopanele tšebeletsong.

The halofo bophelo meriana nako e lihora 0.5-1. Khumo e le derivatives ke a liphio (70-76%) le hammoho le bile (18-24%).

Batho ba nang le a sa foleng le mafu sebete bioavailability ea lithethefatsi e haholo e ile ea eketseha, 'me ka lero la mali halofo bophelo fihla lihora tse 3.

Ka bakuli ba sa foleng excretion lefu liphio liehisa. Hlahellang ho lekana le ho fokotseha ha CC.

Moriana o "Ortanol": seo thusa?

Ba ne ba nka ho lokisetsa e bontšoa bakeng sa ho sebelisoa mafu tse latelang:

• reflux esophagitis;
• gastrointestinal mele lefu seso (ho akarelletsa le thibelo khutlela mokhoeng);
• e re hypersecretory (khatello ea kelello liso tsa intestine le, lefu Zollinger-Ellison, systemic mastocytosis, polyendocrine adenomatosis);
• fele tsa Helicobacter pylori tšoaetso bakuli ba lefu ulcerative tsa pampitšana tshilong ya dijo (ka phekolo motswako);

• kalafo le thibelo ea gastrointestinal mucosal makala tshenyo tse bakileng NSAID (mucosal khoholeho ea mobu, dyspepsia, peptic seso).

Ho thibeloa lithethefatsi tšebeliso ea

Seo ke contraindications lithethefatsi o na le "Ortanol" (ho tloha ho le etsa hore thulusi ena, re ile a re ho ka holimo)? Ho ea ka litaelo tseo, eo ho nkoang lithethefatsi le ke keng la sebelisoa ha:

• diabolololo;
• bongoaneng;
• hypersensitivity ho ntho ea lithethefatsi.

Le khethehileng hlokolosi nkoa lithethefatsi tseo ke li behetsoeng hloleha renal le sebete.

Lithethefatsi "Ortanol": setatemente se

Ena lithethefatsi e balletsweng feela ka hare. E nkiloe feela pele lijo (hangata ka hoseng pele lijo tsa hoseng).

The komiki le moriana le metsitsoe e feletse ka metsi. Boemong bo joalo, haeba mokuli a sa kgone ho sebedisa meriana ka ho feletseng, litaba tsa eona li ka qhalwa ho ya ka e nyenyane ha asiti haholo mokelikeli.

The litekanyetso li behoa ea ea lithethefatsi e itšetlehile ka bopaki.

Ha liso 12 duodenal seso moriana o laolwa ka 20 mg, hang ka letsatsi libeke tse peli. Ka ketsahalo eo ka mor'a selemo pele e feletseng scarring ha ke sa etsahala, boela ba khethiloeng ke libeke tse peli phekolo.

Ka ulcerative lefu manganga ho kalafo, sena moemeli ho buelloa ho nka khatho ea litekanyetso li behoa ea 40 mg, hang ka letsatsi. Mokhoa oa phekolo le lithethefatsi hona ka 'na ea e fetisetsoa libeke tse' nè.

Capsules "Ortanol" matšoao eo ba 'nile ba ho tse thathamisitsoeng ka holimo, ulcerative diso tsa mpeng nka 20 mg, hang letsatsi le letsatsi bakeng sa ho libeke tse' nè. Ha scarring ha etsahala ka mor'a selemo ba feta, ha ho botjha e behiloeng e mene-beke phekolo. Ka gastric seso, manganga ho kalafo, meriana buelloa ho nka e le lethal dose ea mg, 40 hang ka letsatsi (tekanyo ea libeke tse robeli).

Fele tsa Helicobacter pylori o etsoang ho tsoa e motswako phekolo. Ka ho le joalo, le moriana o ha e tsamaiswang ka 20 mg, habeli ka letsatsi pele lijo (bakeng sa libeke tse peli) hammoho le antibacterial mahlahana.

Ha reflux esophagitis lithethefatsi buelloa ho sebelisa ka chelete ea 20 mg, (hang) ka libeke tse 'nè. Haeba mokhoa ona e lithethefatsi hase esengaka hore a phethe pheko, mokuli e hlophisitsweng tsela ea bobeli (libeke tse 'nè). Ka matla kalafo reflux esophagitis sesebelisoa sena e atoloswa ho fihlela ho libeke tse robeli.

Ha hypersecretory boemo ho nkoa e moriana bakeng sa lesokolla tsamaisoa ka bomong. The kgothaletswa qalang litekanyetso li behoa bakeng sa batho ba baholo e 60 mg, (hang), le palo e kahodimodimo - 120 mg,.

Ka ho khetha lithethefatsi tse fetang 80 mg, ka letsatsi, ho e arotsoe mekhahlelo e 'maloa.

Ha gastrointestinal mucosa lekala senya, tse bakoang ke NSAID, hammoho le bakeng sa thibelo ea komiki "Ortanol" khothalletsa tšebeliso ea lethal dose ea mg, 20 letsatsi le letsatsi, pele ja lijo tsa hoseng (bakeng sa nako eohle ea NSAID phekolo).

Bakeng sa ba hōlileng le batho 'me batho ba nang le matla sebete lefu lebetsoeng le letsatsi lethal dose ke ho 20 mg,.

Bakeng sa bakuli ba nang le bokooa a liphio mosebetsi litekanyetso li behoa phetoho e hlokahalang.

lehlakoreng liketsahalo

liphetoho life tse sa lokelang ho etsa hore lithethefatsi "Ortanol"? Reviews re latelang litla-morao:

• hlooho e opang, thothofatsang pono, molikoalikoane, ho etymology multiforme, paresthesia;
• otsela, ho nyekoa ke pelo, tatso ea khathatsoa, letšollo, lefu la ho hlobaela, flatulence;
• pherekano, e omeletseng molomo, ho tepella maikutlo, maloetse, reversible ferekane kelellong;
• magazine, gynecomastia, lefu la sebete, pheriferale edema, ho hlatsa, le photosensitivity;
• bohloko mpeng, thrombocytopenia, pipitlelano, pancytopenia, keketseho ea mosebetsi alkaline phosphatase le sebete transaminase;
• letlalo itchy, phytoteratology sebete mosebetsi, bofokoli mesifa, sebopeho sa cysts gastric glandular;
• alopecia, eosinophilia, e ile ea eketseha ho fufuleloa, bronchospasm, agranulocytosis, angioedema;
• leukopenia, myalgia, feberu, arthralgia, liphetoho anaphylactoid, urticaria, interstitial nephritis.

Le litla-morao tse etsahalang ha a sebelisa mahlahana a ho tlalehelang tse bonolo le e fetang ka tlhaho.

maemo a ho overdose

Ha ho noa meriana ea lesokolla ka mamello latelang matšoao a ka 'na la hlaha: hlooho e opang, molomo o omileng, tachycardia, ho otsela, ho nyekoa ke pelo, pono thothofatsang, ho hlatsa, pherekano, e ile ea eketseha ho fufuleloa.

Tlas'a maemo a joalo, bontshang matshwao phekolo.

ditshebeditsano lithethefatsi

Hammoho le kenoa omeprazole eketsehile ka makhetlo halofo bophelo le eketsehile ka makhetlo mahloriso "Diazepam", "warfarin", "phenytoin", hammoho le tse ling tse lithethefatsi hore tsena metabolized ka sebete le isoenzyme CYP2C19.

Absorption ho bolela ka 'na ba tšoenngoa, ho bioavailability ea eona e laolwang ke acidity ea lero gastric (mohlala, "Itraconazole" "ketoconazole" esters tsa ampicillin "cyanocobalamin" le matsoai tšepe).

The bioavailability tsa digoxin ha sebedisana tsamaisoa ka omeprazole e ile ea eketseha ka 10%.

Ho talingoa lithethefatsi natefisa inhibitory phello e ka hematopoietic tsamaiso ea tse ling lithethefatsi.

Ha ho ea bongaka ditshebeditsano bohlokoa lithethefatsi le lithethefatsi antacid, caffeine, "theophylline", "Quinidine", "propranolol", ethanol, lidocaine le "metoprolol" e sa beha.

likhothaletso itseng

malignancy e lokela e be tse qheletsoeng ka thoko pele tshimololang kalafo le omeprazole. Sena ke ka ntlha ya go ha e le hantle hore sena se phekolo ea lithethefatsi ka 'na ba pata le matšoao' me a lieha ho nepahetse tepelletse maikutlong setatemente se.

Hona joale, ho na le ha ho na ya data ka tshusumetso ya chelete ea ka bokhoni ba motho ho laola mekgwa le khanna likoloi.

Theko le analogues

Ke bokae ena lithethefatsi-ba khahlanong le seso, e le "Ortanol"? Theko ea lithethefatsi ena ke ka 100-115 li-ruble. Bakeng sa bareki ho fetisisa, litsenyehelo tsa ho ena ke e amohelehang.

Ke eng e ka nka sebaka sa lithethefatsi "Ortanol"? Analogs ya ba lokisetsa ho ena tse hlahisoang ka mokgwa wa "omez", "Loseprazol", "Gaseka", "Omelika", "omeprazole".

Reviews

Reviews of capsules "Ortanol" ba-positive, le ho isa tekanyong e moholo. Bakuli ba bolela hore lithethefatsi ke atlehang ka ho antiulcer moemeli. Ho ka potlako felisa lesokolla le boikutlo ba ho ba boima le ho cha mpeng.

Litsebi li bolela hore lithethefatsi ka potso e na le phello e ntle ka tsela ea mafu pampitšaneng ena gastrointestinal feela ha baeti ba fihlelang ho sona e 'nile ea khethiloeng ke gastroenterologist ka. Lingaka li tlaleha hore ba bona ho nka lithethefatsi ena e thibetsoe, ha e ntse e na le phello e matla haholo.

Ho na le e boetse e ea e ntle lehlakoreng la sena meriana ena e kenyeletsa lona ho fumaneha le tlaase theko.