Loantsang likokoana TSifran. tšebeliso ea lithethefatsi

Medicine "TSifran" ke moemeli loantsang likokoana le manyenyane sephara ea ketso le ke oa sehlopha diokobatsi tsa fluoroquinolones. dikarolo mafolofolo tsa lithethefatsi ke ciprofloxacin le tinidazole. Ka lebaka la ho hatelloang ea DNA gyrase le baktheria DNA tswakana thibelo, dintho tsena a sebetsang a ba mafolofolo haholo bakeng sa ho fetisisa microorganisms mob mobile-negative.

Ka ho khetheha, mosebetsi oa bohato bactericidal ya ba lokisetsa ho ea "TSifran" lintlha taeo e pukwanana mabapi le libaktheria tsena: Neisseriagonorrhoeae, Neisseriameningitidis, Haemophilusinfluenzae, Pseudomonasaeruginosa, Salmonellaspp, Escherichiacoli le microorganisms mefuta e meng ho hlahisa le ho se hlahisa penicillinase, hammoho le mefuta e methicillin manganga le Enterococcusspp, Chlamydiaspp, Mycobacteriumspp, Legionellaspp ... mefuta.

bohato diokobatsi tsa bactericidal moriana o sephara a manyenyane "TSifran" litaelo bakeng sa ho sebelisoa e tjena: ". sesebelisoa o ne a rerile hore ho phekola pathologies tšoaetsanoang ka katleho ea ho phekola ba dithulaganyo hlabang - tšoaetso ea e tsoakiloeng halefisoa ke mosebetsi oa microorganisms aerobiki le protozoa".

Pharmacokinetics

Metsoako a sebetsang a ba lithethefatsi "TSifran" litaelo bakeng sa ho sebelisoa e bua haholo lumellana. Le ciprofloxacin le tinidazole na absorption e ntle ka pampitšana ea gastrointestinal.

Nahana ka e mong le e oa metsoako mafolofolo moriana, re lokela ho hlokomela hore ciprofloxacin na ba ka bang 70% bioavailability. absorption lona e liehisa batla, ha ho sebelisa lijo ka. lithethefatsi ena e na le e lumellang metsi ho kena ntle ka lisele le maro a 'mele, ho akarelletsa lesapo, mesifa, mafura, le lefufuru dinama tse nyenyane tse. O kenella ka hare ho ka makala a tsamaiso ea mosese, ho akarelletsa le ho 'mele tse kang ea tšoelesa ea senya e. E ne e le lekunutu ho senola phahameng mahloriso dikahare kiprofloksatsina, e le, ka sebele, le ka peo ea botona, mathe, bile, lisele tsa mmele mokelikeli, mucus.

Tinidazole fapaneng bioavailability feletseng. karolo ena e boetse e oela ka potlako ka concentrations phahameng ka lisele tsa 'mele mokelikeli phunyelletsa mahareng, ka ho khetheha ka mokelikeli cerebrospinal, eo e concentrated ka ho tsoana le ho ka boemo lero la mali. Hoo e ka bang kotara ea chelete ea lintho tse ingested excreted ka moroto sa fetohe, ka 10% Ho lokolloa ka mokgwa wa metabolites, karolo e itseng tse nyenyane haholo tsa motsoako tsoe 'meleng ka masi le.

Bontšang bakeng sa lithethefatsi "TSifran" litaelo bakeng sa ho sebelisoa e bua ka kalafo e tsoakiloeng ba dithulaganyo tšoaetsanoang. Har'a pathologies itseng ho feta, bakeng sa kalafo ya ea lithethefatsi ka eona e leng e sebelisoa, le mafu a latelang:

• foleng osteomyelitis ;

• intra-a tšoaetsanoang a hlabang dithulaganyo;

• amoebic letšollo le letšollo tsoakiloeng mofuta (amoebic le baktheria);

• periodontitis, periostitis le mafu a mang a tšoaetsanoang ea cavity molomo;

• gynecological hlabang bolwetse;

• foleng sinusitis;

• tsoaetsanang ea letlalo le lisele tse bonolo;

• postoperative tshwaetsang;

• matšoafo abscess.

E mong oa bona, 'me mafu a tsoaetsanang a mang a bakoa ke aerobiki libaktheria nahanela ketso ea likarolo ho ea lithethefatsi.

Moamohetseng ho lokisetsa "TSifran" postprandial. Tablets lokela ho ho nkoa ka ka metsi ka bongata bo lekaneng. bakuli ba batho ba baholo etellang lithethefatsi habeli ka letsatsi bakeng sa letlapeng la 500 / 600mg kapa tse peli ba 250 / 300mg. Bakuli ba tlaase ho lilemo tse lilemo tse leshome le metso e robeli la lilemo, lithethefatsi le e sa tsamaisoa. E sa kgothaletswa bakeng sa ho sebelisoa e le moimana.

Contraindications ho tshebediso ya lithethefatsi tse hlalositsoeng ho phekolo ke li eketsehile ho nahanela ho dikarolo ea eaba ba etsa karolo ea tsifran le bolwetse mali, porphyria.