Lithethefatsi 'Warfarin'. Litaelo tsa tšebeliso

Lithethefatsi "Warfarin" litaelo bakeng sa ho sebelisoa e bua ka dihlopha tsa anticoagulants ba sa tobang bohato. Lithethefatsi ke kgona ho thibela metsoako e tswakana mabaka hoama (vithamine ea K-e itšetlehileng) hammoho le protheine e nang le C le S ka sebete. Homolog anticoagulant e le hantle o ile a re ka letsatsi la boraro kapa ea bohlano ka mor'a hore qalo ea phekolo le fediswa mor'a matsatsi a mararo ho tse hlano ka mor'a hore lethal dose ho qetela. Lithethefatsi e fumaneha ka foromo Letlapa.

E kgothaletswa ha noa moriana "Warfarin" seratsoana akarelletsa ho lula hoo e ka bang ka tsela e lekanang oa vithamine ea K ka ja lijo ho

ya litatoli na

moriana o ile a bontša ho thibela le kalafo ea thrombosis le thromboembolism. Ke matšoao a ho lithethefatsi "Warfarin" taeo pukwanana amana thromboembolism le thrombosis hlobaetsang venous, embolism methapo, boipheto tsa infarction myocardial, thrombosis postoperative. ba lokisetsa ho ea e hlophisitsweng bakeng sa ho kenya tshebetsong le thromboembolic tlosa kapa thrombosis buoa (jwalo ka ho bolela e eketsehileng) ho atrial fibrillation (motlakase cardioversion), relapsing (boela) mothapo thrombosis, embolism ka mothapo ho methapo. Le bolela "Warfarin" taeo pukwanana khothalletsa ka prosthetics vascular le di-valve pelo (e lumelloa le ho sebelisa ho kopantswe ea acid e acetylsalicylic). Ho feta moo, lithethefatsi le e hlophisitsweng bakeng sa thrombosis, bokong, gogoga le pheriferale methapo, hammoho le thibelo ea bobeli ea thrombosis kapa embolism nakong ea panya tsa atrial e kapa ka mor'a infarction.

Contraindications ho bukana lithethefatsi "Warfarin" taeo e go baya ka ditlhopha mamellane motho, renal kapa lefu e amanang le sebete haholo, a hlobaetsang le hemorrhage, kgatelelo ya madi (boima mofuta), exacerbation ea liso ka mpeng kapa duodenum, hemorrhagic diathesis, lebaka la ho hloka S le C lihaha-'mele, bokhoba ba tahi, hemorrhage bokong, renal mosebetsi insufficiency, a hlobaetsang le DIC, thrombocytopenia. Thonya lithethefatsi nakong ea bokhachane.

The atileng ka ho fetisisa liketsahalo tse bohloko nakong ea tsamaiso ea lithethefatsi "Warfarin" e tsoa mali. Maemong a sa tloaelehang, ho na le necrosis ea letlalo, e ile ea eketseha sebete enzyme, letšollo, eczema, tahlehelo moriri, vasculitis.

litekanyetso li behoa

moriana o ile a bontša bakeng sa tsamaiso molomo. Recommended kopo se nang balekane, ho ka nako e tšoanang. Qalong lethal dose - tse peli le halofo ho milligrams tse hlano ka letsatsi.

Morago ga moo e dosing Melao "Warfarin" (INR kapa nako prothrombin ha ena e elwa hloko) ikemiselitse bomong. Ka makhetlo a mabeli ho a mane ho tloha mohloli lokela ho ea eketseha nako prothrombin. Tabeng ena e INR (machaba boetse maemong karo-karolelano) lokela ho finyella (ho itšetlehile ka bolwetse kgonego ya mali, thrombosis kotsi) 2.2-4.4.

Bakeng sa bakuli ba hōlileng kapa ka boemo ba fokola balletsweng tekanyetso e ka tlaase ea lithethefatsi "Warfarin".

Pele atamela tshebetso (tabeng ea predisposition ho ntshetsopele ya mathata thromboembolic) phekolo e qala matsatsi a mabeli kapa a mararo pele ho kenella ka.

Ka thrombosis kalafo a hlobaetsang le o etsoang tsoa hammoho le lithethefatsi "Heparin" ho fihlela nako eo ha anticoagulant e le hantle e sa ka ho feletseng o ile a bontša (hangata se pele ka letsatsi la boraro le la bohlano la).

Ka nako ea phekolo e itšetlehile ka boemo ba mokuli.

Pele ho qaleha ha kalafo ke ho hlokahala hore ho fumana hore na e INR index ea (ho ya ka nako prothrombin, fuoa nahanela coefficient thromboplastin).

Ho ea ka bakuli ba bangata, litlhare "Warfarin" hase feela e atlehang, empa hape e loketseng, kaha e lokela ho nkoa ka hang ka letsatsi feela. Ho phaella moo, ho bolela hore e hantle mameletse, litla-morao tse ka seoelo. Leha ho le joalo, pele ho ho sebedisa sehlahiswa, o lokela ho buisana le ngaka e, 'me bala litaelo ka hloko.