Inhibitors proton e pompo: mochine ea nkang khato le ho sebelisa ka moriana

Ke inhibitors proton e pompa ke sehlopha sa baemeli ba diokobatsi hore fokotsa tekanyo ea secretion ea acid e hydrochloric ka mpeng. Ho ba le phello e ka ho toba ka canaliculi secretory, ba ka katleho lebisa ho lakatsa liso phekolo e le hantle, erosive gastritis, Gerd. sehlopha sa akarelletsa plurality ea lithethefatsi ea tšoanang sebopeho lik'hemik'hale, empa ho ba le entsprechen fapaneng pharmacodynamic, i.e. hoo e batlang e le lithethefatsi e tšoanang sebetsa ka lisele secretory, empa etsa joalo ka concentrations fapaneng le ka lebelo e fapaneng.

inhibitors proton e pompo: likarolo tse limolek'hule litokisetso tšusumetso e

Proton e pompa ke rarahaneng protheine sebopeho setlhongwa ho kenella ka hare tsa ions hydrogen ka lumen gastric. Ho na le tse peli tse likarolo lik'hemik'hale dissimilar, ho seng joalo e bitswang subunits. Ea pele ke feela ba nang le protheine le e hahiloeng ho tloha-amino acid. Ka lera seleng ea stuffer ho itshwara ka tsela e khethehileng, tšela ka makhetlo a 10, e leng e isa hore ho thehoe loops 5-secretory le kanaleng. Ea fetang ka cavity tsa ions oela ka hara lumen gastric be u fane ka acidification ba mahareng le oela index ea hydrogen. Tabeng ena e ho e mong oa loops ke setsi sa mafolofolo tsa protheine ea - ka tatelano ea 800 amino acid, e catalyzes ho sithabela tsa ATP, ba ka sehloohong eneji, le seleng ea substrate.

Tse ling yuniti e nyane ke protheine e rarahaneng e entsoeng ka a latellana joang polypeptide, ka ho latellana e itseng o ile a laela sebopeho le liketane glycoprotein. E leng karolo e hlollang ea molek'hule e kantle cytoplasm, 'me e le karolo ea glycoprotein mohlomong ekstratsitoplazmaticheskim receptor rarahaneng hore popolari ka ba pontšo ea Tshebediso ya a potlakisang tsebetso ea lik'hemik'hale H + \ K + -ATPase. Tabeng ena le protheine karolo e itseng ea molek'hule le lifapano lera le hang, a fana ka maikutlo boleng lona ka elements o tlohang pakeng tsa ka ntle 'me ba pele receptor yuniti e nyane le boikarabelo ba ho khanna catalytic itsoara joang ka tsa tswakana tsa protons.

Ka lebaka leo, ho sebopeho sa le proton pompo tubules secretory lisele tse parietal ka fihlela qeto ea kamoo e bonolo tsela ka thibela secretion ea H + ka cavity mele. Ka ho fetisisa ka lokafatsoang mothofatso - ke thibelo ea potlakisang tsebetso ea lik'hemik'hale le boikarabelo ba ho tswakana hore etsa inhibitors proton e pompo.

Tshebediso ya inhibitors ikatisetsa tlelenike

Ka moriana, inhibitors proton e pompa ba ho pharaletseng a sebelisa, haholo-holo gastroenterology, e leng e tse amanang le ho matla a bona a ho fokotsa ho acidity ea gastric secretion, 'me kahoo fokotsa matla a phello e kotsi leboteng mala, e leng bohlokoa ka ho khetheha ha ho e fubileng. Tabeng ena phello phekolo e ikemetse ea etiology ea ho hlabang, joalokaha ho tlosoa ke tšusumetso ea mabifi ea tikoloho ka botšepehi ba 'mele. Hape le a manyenyane ba pathologies eo kalafo bakeng sa ho sebelisoa ka katleho le proton pompo inhibitors e se e atolosoa ke seso gastric le duodenal seso, erosive le batho bao e seng erosive liforomo Gerd.

Har'a meriana atileng ka ho fetisisa li akarelletsa le proton pompo inhibitors le latelang mabitso karela omeprazole, rabeprazole, pantoprazole, lansoprazole, esomeprazole, 'me ba bang. Har'a bona ke mabitso a khoebo ea totobala, a kang "Omez". Meriana tse fumanehang foromo komiki. Ba ba isoa ka molomo ka litekanyetso li behoa balletsweng ke ea setsebi, e leng fapana ho itšetlehile ka mofuta o itseng oa lefu. Ha a ntse a ho lumella ho intša taolo, e le ho na le ke sehlopha ea bakuli ba tletleba ba exacerbation ka linako tse itseng tsa liso foleng gastric kapa duodenal. Maemong a mang, le baeti ba fihlelang ho e buisana le ngaka ka nako e sa kenoa.