Analogs le litaelo bakeng sa ho sebelisoa "lomefloxacin"

Ke eng e ka nka sebaka sa lithethefatsi tse kang "lomefloxacin"? Analogs ea lithethefatsi, ke morero oa oona, 'me o behile lithibelo ho sebedisa thepa ho phekola li tšohloa mona ka tlase. U tla boela u ithute ka ho sebelisa hantle sesebelisoa sena, le ka litekanyetso li behoa ke eng.

Foromo ya lithethefatsi, ambalaji lona, 'me likarolo tsa lona karolo

Eo sephutheloana e fumaneha ha matlotlo joang? Moo ho fana ka taeo e ka kopo? "Lomefloxacin" - letlapa, kenngoa ka machachetsi le tsa phutheloa ka dipakete pampiri, hammoho le kakaretso ya.

ke eng metsoako akarelletsa lithethefatsi? The a sebetsang a motsoako oa lithethefatsi ke lomefloxacin hydrochloride. Hape e akarelletsa dikarolo tse ding thusang.

The phekolo thepa ya moriana

ke lipilisi "lomefloxacin" ke efe? e re Manual hore ena bactericidal loantsang likokoana meriana bo tsamaisanang le chelete sehlopha antibiotikopodobnyh, ke hore, fluoroquinolones, 'me o emetse moloko oa bobeli oa lithethefatsi tsena li ka.

Ke'ng se etsang hore ba loantsang likokoana bohlokwa ba tsamaiso ya lithethefatsi ka eona? thepa joalo "lomefloxacin" Tablets (400 mg,) ile a fumana leboha ha e le hantle hore ntho bona a sebetsang a khonang ho ba le phello e thibela ka DNA gyrase (i.e. baktheria potlakisang tsebetso ea lik'hemik'hale) eo e fana ka supercoiling. Ho feta moo, moemeli ena etsa hore motsoako tsitsitseng (rarahaneng) le tetramer lona le sitisa tsamiso ya ho DNA mongwalollo le ikatisa lisele tse ea baktheria, a etsa hore timetso ea bona e ileng ea latela.

The a bolela mosebetsi oa moriana o ka bonahala e batlang e mpe libaktheria aerobiki kang gonococci e, Salmonella, Pseudomonas, ba haemophilus le Escherichia coli, k'holera pathogen, meningococci, Shigella, Morganella joalo joalo. Hape moriana o "lomefloxacin" (400 mg,) nyahamisa phello e Proteus, chlamydia, Campylobacter, mycoplasma, legionella, ba bang ba pneumococci le staphylococci.

Re ke ke ra bolela hore lithethefatsi o ile a re ke haholo e atlehang khahlanong Mycobacterium lefuba. O khona ho fokotsa nako ea ho tlosa bona, hammoho le resorption pele tsa infiltrates fumaneha.

Phekolo e le hantle "lomefloxacin" hlokomela esita le ka concentrations lona tlaase maling. Ha ho hanyetsa sena se o ile a re ka seoelo haholo.

bokhoni ba Kinetic matlapa moriana

Kamoo ananelang itse moriana o? Seo e se buang ka litaelo bakeng sa ho sebelisoa? "Lomefloxacin" o absorbency molemo. Ka mor'a ho fumana meriana lona tlhōrō lero la mali mahloriso fihlellwa mor'a metsotso 55-85.

The lero la mali protheine tlama ho ea lithethefatsi a le mong feela ka 10%. Hape, ho na le lona thepa e ntle absorption ka makala a sa tšoaneng le lisele tse (ho akarelletsa le mapele ya, manonyeletso, litsela tsa ho hema, litho tsa Ent, litho tsa pelvic, masapo, mpeng, lisele tse bonolo, joalo-joalo), moo dikahare tsa lona ke makhetlo a 5-7 e phahameng lero la mali.

Re lokela ho hlokomela hore ba bang ba lomefloxacin metabolized le e bopa derivatives 'maloa.

Nako ea excretion ea lithethefatsi ke 9 lihora. Khumo e ka tsela secretion tubular ka moroto (70-85%) le fumaneha mantleng (25-30%).

Bontšang bakeng sa lebitso le ea mokhoa oa ho

batho ba seng bakae tseba, empa famasi liketane ka fumanoa ha feela pilisi "lomefloxacin", empa hape lithethefatsi "lomefloksatsin + pyrazinamide + ethambutol + Prothionamide + Pyridoxine". Tabeng ena bobeli ba itse moriana o ba bontša bakeng sa ho sebelisoa:

• tsoaetsanang (purulent) letlalo le dinama tse nyenyane tse bonolo (ho akarelletsa le chesa, maqeba nang le tšoaetso, joalo-joalo);
• osteomyelitis;
• chlamydia le qhoshola (ho akarelletsa le Blepharoconjunctivitis le chlamydial conjunctivitis);
• tsoaetsanang pampitšana Gastrointestinal (mohlala, k'holera, letšollo, feberu ea mala, salmonellosis);
• tsoaetsanang matšoafo (ho akarelletsa le la bronchitis foleng, mofuta iphetang);
• biliary pampitšana tšoaetso ea;
• tsoaetsanang sebakeng urogenital (mohlala, urethritis, prostatitis, cystitis, pyelonephritis);
• lefuba methapo (ho akarelletsa le ho kalafo ya batho ba nang le diforomo ka potlako a hatela pele ea lefu lena le, hammoho le eketseha ho hanyetsa "isoniazid" le "Rifampicin" le ka ho hanyetsa ka chemotherapy);
• pele le ka mor'a transurethral ho buuoa (feela bakeng sa merero e prophylactic).

Ho thibeloa ha ho khethoa matlapa loantsang likokoana

Maemong a mang, u ka se sebelisa lithethefatsi ka eona? Seo ena e re bolella taeo e pukwanana? "Lomefloxacin" e contraindicated bakeng sa ho sebelisoa:

• emara;
• kanyeso;
• nahanela botho ea lithethefatsi bao e leng sehlopha se fluoroquinolone;
• e le bana (mohlomong thibelo ea ntshetsopeleng ya marapo).

Litaelo tsa tšebeliso

"Lomefloxacin" - lipilisi tse feela ho bontšoa hore a e-ja. Ba lokela ho ho nkoa ka hang ka letsatsi, ho sa tsotellehe lijo, ho noa ka 230 di ml tse metsi a tloaelehileng.

The nako ya kalafo le moriana ena e itšetlehile ka tepelletse maikutlong le, hammoho le ho tiea tsa lefu le nahanela ya pathogen ena.

Bonolo hlobaetsang la bronchitis le bronchopneumonia phallo tšoaroa litekanyetso li behoa ea mg, 400 tsa moriana fetang matsatsi a leshome.

Ka ho phekola chlamydia (urogenital), ho akarelletsa le tšoaetso ea baktheria le chlamydial, gonococcal le chlamydial, bakuli ba tsamaisoa 400-600 mg, ea lithethefatsi ka letsatsi, ka nako ya tshebediso ya ho matsatsi a 28.

Phekolo ea relapses thata serame sa matšoafo le sa foleng mofuta la bronchitis etsoa ka litekanyetso li behoa ea letsatsi e lekanang ho 400-800 mg, ea lithethefatsi, ka libeke tse peli.

Ha mycoplasma tshwaetso nkoa lithethefatsi laetsoeng ho 400-800 mg, ka letsatsi, ka nako ya tsamaiso ya matlapa a ka libeke tse 3.

Mosese pampitšana tshwaetsang amenable ho phekolo 400 mg, ea moriana. Le ena kalafo la linyeoe bonolo phethile matsatsi a 5, ho ena le tse rarahaneng - matsatsi a 14.

Ka qhoshola hlobaetsang lithethefatsi "lomefloxacin" kgothaletswa ho nka litekanyetso li behoa ea 600 mg,. Ha e le sebōpeho sa foleng ba lefu lena le, kalafo lona o etsoang ho tsoa e e tšoanang le immunotherapy itseng. Tabeng ena, o ile a nka meriana e tšoanang letsatsi le letsatsi lethal dose matsatsi a 5.

Kalafo ea lefuba methapo e ka nka matsatsi a 14-30 (ka linako tse ling ho fihlela ho likhoeli tse 3). Joalo lefu le ho phekola lithethefatsi lethal dose ea 200 mg, ka makhetlo a mabeli ka letsatsi.

Ha a bontša hore pathologies renal kapa mofuta itekanetseng, hammoho le batho ba hlahetsoeng ke hemodialysis, "lomefloxacin" li tsamaisoa ka palo ea 400 mg, ka letsatsi, le fokotseha lona ka ho eketsehileng le 200 mg,.

Lipono tse makatsang tsa botho ba mpe

litla seo mpe li ka etsa hore lipilisi "lomefloxacin"? Tataisa lintlha ho itsoara joang ka tse latelang:

• bronchoconstriction, e ile ea eketseha mucus secretion, ho nyekoa ke pelo, ho khohlela, dysphagia;
• dyspnea, ho hlatsa, tšoaetso ea matšoafo, letšollo, goiter;
• matšoao a ntaramane-joaloka, dysgeusia, epigastric bohloko, bloating;
• bophahamo ba enzyme sebete, omile ea molomo, gastrointestinal mali;
• pipitlelano, arthralgia, namane cramps, fetola puo ya mmala, myalgia;
• pseudomembranous colitis, ho tšoaroa ke hlooho, ho fetoha ha takatso ea lijo, vasculitis, ho tsekela;
• lefu la ho hlobaela, letsoele mosa le ka morao, mokhathala, ho tšoha, a ka ikutloa a malaise kakaretso, ho tepella maikutlo, ha thothomela hohle;
• hyperkinesia, mokhathala, tsitsipana, lipono;
• bohloko mahlong, lerata, le bohloko ka litsebeng tsa;
• dysuria, e ile ea eketseha tsoheloa, hematuria, paresthesias;
• crystalluria, thothofatsang Pono;
• albuminuria, glomerulonephritis, Leucorrhœa, edema, polyuria, epididymitis, bothata ba ho ntša metsi, orchitis, tenesmus;
• cyanosis, anuria, hypotension, vaginitis, tachycardia, arrythmia, perineal bohloko, bradycardia;
• intermenstrual mali, thrombocytopenia, ka bosaling candidiasis, myocardial infarction, cardiomyopathy, phlebitis;
• le letotong la hloleha pelo le angina, purpura, mafu cerebrovascular, ho hlohlona la letlalo;
• embolism methapo, photosensitivity, eketsa fibrinolysis, lekhopho, lymphadenopathy, lekhopho;
• epistaxis, etymology (bolaeang), ikutloa chills, gout, chesang mahlaseli;
• superinfection, hypoglycemia, Candida, le boikutlo ba lenyora.

E overdose ea lipilisi

Ka overdose ea lipilisi "lomefloxacin" bakuli ba ho nyekeloa ke pelo, diso erosive tsa mucosa gastrointestinal, lelefatsa QT-nako, ho tsekela, sethoathoa, pherekano, hammoho le eketseha liphetoho boima.

Hobane hemodialysis overdose ho bolela ho nkoa phekolo thuso holimo maemo e phethahatsoa ka lebaka la matšoao a leng teng.

Sebelisana le lithethefatsi tse ling

Le ha e kopana le "lomefloxacin" le "theophylline" metabolism hae hoo e ka bang thibang.

Ha tsamaiso ea tsoa hong ea antacids le sucralfate di thehoa chelate mehahong eo fokotsa bioavailability tsa lomefloxacin. Ke ka lebaka leo karohano pakeng tsa baeti ba fihlelang ho ba o ile a re medicaments e lokela ho ba bonyane lihora tse 4.

Kopanetsoeng tšebeliso ea "lomefloxacin" le tekanyetso e phahameng ea caffeine e lelefatsa ea halofo ea bophelo ba e qetellang.

Ka ho phekola lefuba ha lia lokela ho tšoaroa ka e tšoanang le baeti ba fihlelang ho ba chelete "Rifampicin", ho seng joalo e tla etsa hore antagonism bohato.

Tsoa hong kalafo le NSAIDs eketsa toxicity ea lithethefatsi le ka etsa hore sethoathoa.

"Lomefloxacin" khona ho eketsa bokgoni ba ho anticoagulants bakeng sa tsamaiso molomo.

Meriana, e leng blockers ea secretion tubular, thibela metsoako ea excretion ea "lomefloxacin".

likhothaletso itseng

Haeba lefu le renal hloka phetoho e tlamang ea litekanyetso li behoa, e itšetlehile ka QC metrics.

phekolo eohle eo u lokela ho qoba ho tšusumetso e telele leha e le efe mehloli UV khanya, ho akarelletsa le mahlaseli a letsatsi.

Vithamine mahlahana a kenyeletsa additives tse fapa-fapaneng matsoai lokela ho nka metsotso e 120 ka mor'a kapa pele ho nkoa e le ho fumana lipilisi.

lithethefatsi tšoanang

Moriana o "lomefloxacin" o analogues tse ngata. Ba ka sehloohong le ka nkang sebaka lithethefatsi litsebi nahana ka tse latelang: "Abaktal", "Elefloks", "Zanotsin", "TSifran", "Avelox", "Tsiprolet", "Zofloks", "tsiprinol", "Kvintor" "Ciprofloxacin", "Levofloxacin "" tarivid "," Levotek "," pefloksatsina "," Levofloks "," Ofloxacin "," Norbaktin "," Ofloks "," norfloxacin ".

Tablets "lomefloxacin": ulasan pelanggan

Ha ho hlaka hore na moemeli tšoaetsanoang hore e ela hloko ho moloko oa bobeli oa fluoroquinolones, hammoho le tlhopho nepahetseng ya tekanyetso meriana le ho phekoloa ka nako e telele, ulasan pelanggan mabapi le hore na ea hona joale ke feela e nepahetseng.

Ho ea ka dipolelo tsa bakuli, lithethefatsi ena e bile ka boeona e ka e meriana e atlehang loantsang likokoana hore ho lekaneng e sebetsana le microorganisms tse fapa-fapaneng pathological. Leha ho le joalo, ba bang ba basebedisi ba re ka linako tse ling lithethefatsi ena e etsa hore tsoelo-pele ea bana kapa litla tse ling lehlakoreng, empa e le busa, ba ile ba ba kula-hlalosoa tsa tlhaho kapa ba se ba hang-hang ka mor'a bofelo ba phekolo.