Ke peptides natriuretic eng?

Joalokaha ho ile ha hlalosoa ka nakong e fetileng tsa morao tjena, ho phaella ho totobetse mesebetsi pelo o etsa karolo ea endocrine lekala. Ho tsosa thahasello e seng feela har'a theorists oa tsa bongaka, empa hape har'a lingaka. Natriuretic peptides (NUP) tšoauoa, eseng feela ka myocardium, empa hape a 'maloa a litho tsa ka hare tse ling tse ka hare, pele nyelisa mesebetsi endocrine. Ho ile ha etsoa qeto e kopanetsoeng ho sebelisa ditirisanommogo litsupa NFA maling bakeng sa bolela lintho esale pele ba pathologies cardiac, ka mokhoa ona e ne e le bonyane itaolang le bonolo ho ba le mamello.

Ho sibolloa ha endocrine mosebetsi oa pelo

peptides Natriuretic 'nile ha fumanoa ka eighties tsa tse lekholo tse fetileng, ha bo-rasaense ba neng ba bone mabapi pakeng tsa tsitsipano ea likamoreng tse ka pelo le tiisetso ea secretion ea moroto. sibolloa le qalong nahana hore e ne e le lipono tse makatsang reflex 'me ao fa bolelang.

Hamorao, ha ho ithuta potso ena tsoa pathologists le sobotta, ba ile ba fumana hore ka lisele tsa dinama tse nyenyane tse, e le karolo ea atrium, ho na le inclusions nang limolek'hule protheine bona. Ho 'nile ha experimentally bontšitse hore ho ntsa ho tswa ho atria tsa likhoto hlahisa matla diuretic phello. Ebe o ile a atleha ka ho itšehla ea peptide le tatelano ea litlhaka kahare amino acid e le hore etsa hore e.

Hamorao, biochemists di khetholloa protheine ka dikarolo tse tharo tse arohaneng (alpha,,, beta le sa gamma), a fapaneng, eseng feela ka sebopeho lik'hemik'hale, empa o boetse o na phello ea alpha, e ne e le matla ho feta ba bang ba babeli. Jwale khetholloa:

- atrial NUP (mofuta A);
- NUP bokong (mofuta B);
- urodilatin (mofuta C).

Biochemistry natriuretic peptide

peptides All natriuretic ke tshwanang ka sebopeho le fapana feela qetellong radicals nitrogenous kapa tokisetso ea liathomo k'habone. Kajeno, tsohle a lebisa tlhokomelo e lebeletse ho litsebi tsa metsoako NUP mofuta B, joalokaha ho e na le mofuta o tsitsitseng haholoanyane ka lero la mali mali, 'me hape lumella u ho fumana liphetho tse ling tsa boitsebiso bo rutang. Atrial NFA phetha karolo ea mong oa correctors metsi le electrolyte ho leka-lekana ea 'mele. E ya hlahiswa ho myocardium ka tloaelehile bobeli le ka ho hloleha foleng pelo.

E paka hore selelekela ea boko NUP na le litlhaka kahare ea 108 amino acid e ba tsa maiketsetso ke lisele tse sa ventricle letšehali. Ha molek'hule otshnurovyvaetsya tloha cytoplasm, e leng potlakisang tsebetso ea lik'hemik'hale furin ketso ho eona, e leng se etsang protheine ena foromo lona a sebetsang a (32 amino acid ea 108). NUP boko teng maling a metsotso 40 feela, ka nako eo bole. Ho eketseha le protheine tswakana amanang le eketsehile ka makhetlo tsitsipano ventricular leboteng le ischemia cardiac.

Excretion UNYP tloha lero la mali o etsoa ka litsela tse peli tse ka sehloohong:

- bokaholimo ba matsoele tsa enzyme lysosomal;
- proteolysis.

A karolo ea isang e hulwa phello nke lehlakore endopeptidase molek'hule, empa mekhoa bobeli kenya letsoho hore ho ho felisoa ha ho peptides natriuretic.

tsamaiso e khopo receptor

liphellong tsohle tsa peptides natriuretic di phethwa ka lebaka la ho sebelisana le receptors bona sebakeng boko, methapo ea mali, mesifa, lesapo le adipose dinama tse nyenyane tse. Lekana le mefuta e meraro ea NFA le ho na le mefuta e meraro ea receptors - A, B le C. Leha ho le joalo, ba aba "mesebetsi" ha ho joalo totobetse:

- receptors mofuta A sebelisana le atrial le boko NUP;
- mofuta The a leka feela ho urodilatin;
- receptors ka tlama hore ba mefuta eohle tse tharo tsa limolek'hule.

Receptors tse feletseng fapaneng le e mong le tse ling. Mefuta A le B li etselitsoe ho kenya tshebetsong liphello intracellular tsa receptors natriuretic peptide le mofuta C lia hlokahala bakeng sa biodegradation ea limolek'hule protheine. Ho na le likhopolo-taba tse kgahlamelo ya maqhubu a ea UNYP bokong etsoa feela ke mofuta wa A receptor, empa hape le likarolo tse ling tse phopholetsa tse amohele chelete ea cyclic guanosine monophosphate.

Palo e khōlō ea mofuta C receptors fumanoang ka lisele tsa boko, litsoelesa adrenal, liphio, 'me lijana. Ha UNYP molek'hule tlama ho receptor tsa mofuta C, e ananelang sele le e khomaretse le receptor mahala e khutlela lera la.

Physiology natriuretic peptide

Boko le atrial peptides natriuretic sebedisa litla bona ka tsamaiso ea likarabo rarahaneng fisioloji. Empa kaofela ba ile ba ile ea qetella e etsa hore e be pakane ea e tšoanang - fokotsa preload ka pelong. NUP ama pelo, endocrine, excretory le e bohareng tsamaiso ea methapo.

Ho tloha ka limolek'hule tsena na le amana le ho receptors tse sa tšoaneng, ho fagahlelwago, liphello tsa mefuta e itseng ea NFA tsamaisong e itseng, ho ke ho le thata. Ho feta moo, peptide phello e itšetlehile eseng feela ka mofuta oa eona, empa ka lefelo phopholetsa receptor.

Atrial natriuretic peptide bolela peptides vasoactive, i.e. le phello e ka ho toba le bophara vascular. Empa ntle le hore ho ke ke khona ho susumelletsa ho hlahisa oxide e nitric eo hape e khothalletsa vasodilation. NUP A le B na le mofuta tšoanang le tataiso la lebotho la bohato ka mefuta eohle ea lijana, le P-mofuta haholo atolosa methapong feela.

Tsoa ho 'nile ha boleloa hore ho NFA lokela ho lemoha se feela ka vasodilator, empa haholo-holo e le antagonist tsa vasoconstrictor. Ho phaella moo, ho na le lithuto tsa hore li bontša hore peptides natriuretic susumetsa kabo ea mokelikeli ka le ho tsoa marangrang capillary.

litla Renal tsa peptide natriuretic

Ka peptide natriuretic ka boleloa hore ke stimulant diuresis. Haholo-holo NUP mofuta A eketsa renal phallo ea mali 'me se eketsa khatello ea ka lijana tsa glomeruli ena. Sena, le eena, eketsa karaoke set glomerular. Ka e tšoanang mofuta nako NUP C eketsa excretion ea ions sodium, 'me sena isang ho lahleheloa ke ka ho eketsehileng ea metsi.

Ka hona bohle ba phetoho efe kapa efe bohlokoa tsamaisong khatello ea e sa hlokomela, esita le haeba boemo peptide eketsehileng ka makhetlo a mangata. litsebi tsohle lumellana hore liphello tsa hore peptides natriuretic ikitlaetsa ka liphio, lia hlokahala bakeng sa khalemelo ea metsi le electrolyte ho leka-lekana ka pathologies foleng ea tsamaiso ea pelo le methapo.

Litla ka CNS

Boko natriuretic peptide ka atrial, a ke ke phunyeletse ho ea mali-boko mokoallo. Ka lebaka leo, ba ile ba ama tsamaiso ea methapo dibopeho teng kantle ho eona. Empa le hoja ba bang ba sa NFA e secreted ke lera la boko ba le libaka tsa lona tse ling.

Liphello bohareng peptides natriuretic leshano ka taba ea hore ba matlafatsa o teng liphetoho pheriferale. Kahoo, ho etsa mohlala, le ka phokotso ea ka cardiac preload 'mele decreases hlokahale lona bakeng sa metsi le matsoai matsoai,' me hape e fetola molumo oa tsamaiso ea methapo autonomic ka tataiso ea karolo parasympathetic.

batshwai laboratori ea

Khopolo ea ho nka natriuretic peptide and analysis nakong mafu a ea tsamaiso ea pelo le methapo e simolohile lilemong tse qalang tsa 90-ogy ea tse lekholo tse fetileng. A lilemo tse leshome hamorao, lingoliloeng pele liphello tsa ho etsa lipatlisiso sebakeng sena. Ho ile ha tlalehoa hore B-mofuta NPU rutang ha lekola le ho tiea tsa ho hloleha pelo le boleloa esale pele ka letotong lefu.

Protein dikahare o ne a ikemiselitse ka mali venous kaofela, tsoakane le EDTA, kapa ke ho sebelisa and analysis immunochemical. Ka tloaelo UNYP boemo ba lokela ho sa feteng 100 Ng / ml tse. Ho feta moo, ho ka etsahala ho bona hore boemo ba selelekela NFA dessyecik mokhoa electrochemiluminescent. moriana tse ruuoang, ho se be le mefuta e fapaneng joalo ba se sebelisang e amahanngoa immunosorbent thlahlobo e le mokhoa oa bokahohleng ho beha chelete ea ntho e ka serum mali.

Boikemisetso ba ho se sebetse cardiac

Natriuretic peptide (ntho e tloaelehileng - ho fihlela ho 100 ka ng / ml tse) ke jwale ka ho fetisisa ratoa le morao-rao ka ho fetisisa lesupa ho beha cardiac mesifa ho se sebetse. The lithuto tsa pele tsa peptides ba ne ba amana le mathata a khethollo ea ba sa foleng ho hloleha ho potoloha ha mali 'me a sa foleng obstructive lefu methapo. Ho tloha ka matšoao tlelenike ne tšoanang, teko thusa ho khetholla sesosa sa maloetse a 'me noha ntshetsopele tse ling tsa lefu lena.

The bolwetse bobeli, leo e undergone ho ithuta ka tsela eo sena, e ne e le ischemic lefu la pelo. Bangoli ba lithuto tsa lumela hore tlhaloso ea boemo ba NFA thusa ho theha hakanngoa shoang kapa boipheto ka mamello. Ho phaella moo, a maholo Tracking NFA boemong ba ke lesupa ya bohlokwa ba tsamaiso kalafo.

Hona joale, boemo ba NFA ikemiselitse ho bakuli ba cardiomyopathy, kgatelelo ya madi, stenosis likepe tse khōlō le mafu a mang ho potoloha ha mali.

Sebelisa ka ho buoa cardiac

Empirically e 'nile ea senola hore boemo ba atrial natriuretic peptide maling ka ho nkuwa jwalo ka e pontshi tsa ho tiea la boemo bo le tshebetso ya ventricle letšehali bakuli pele le ka mor'a ho buuoa cardiac.

Ho ithuta ketsahalo eo e qala ka 1993, empa feela e ile ea fihla ka tekanyo e khōlō ka 2000s le. Ho ile ha fumanoa hore ho na le ho fokotseha bohale palong ea NUP maling pheriferale, haeba pele boemo ba sona e se e sa khaotse ntlafatswa, fana ka maikutlo a hore ho sebetsa ha myocardium le e fokotsehile 'me ke buuoe e ile ea atleha. Haeba phokotseho NFA ne ke sa etsahala, mokuli a shoa ka 100% kgonego. Kamano pakeng tsa lilemo, ho kopanela liphate le boemo ba peptide ba 'nile ba ka hlaloswang Ka hona, palo ena e bokahohleng ho dihlopha tsohle tsa bakuli.

Itse'ng ka mor'a ho buuoa

Pele ho buuoa cardiac natriuretic peptide eketseha. Ka mor'a hore tsohle, haeba ho ne ho seng joalo, ka nako eo ho hlokahalang kalafo e ne e le sieo. Boemo bo phahameng ba bakuli NFA pele kalafo ke Ntho e sa thabiseng hore haholo susumetsa ya itse'ng ka mor'a ho buuoa.

Ho tloha ka sehlopha le khethiloeng bakeng sa ho ithuta e ne e le nyenyane, liphello e ne e tsoakileng. Ka lehlakoreng le leng, qeto ea hore na boemo ba NFA pele le ka mor'a ho buuoa dumella lingaka hore li bolela esale pele eo a lithethefatsi le tšehetso sesebelisoa tla hlokahala hore a phethe hlaphoheloa ea pelo ea mesebetsi ea eona. Hape e ne e ile ka hlokomela hore e ile ea eketseha palo ya NUP mofuta B ke selelekela sa fibrillation atrial ka nako postoperative.