Interferon inducers, lithethefatsi bakeng sa bana: lethathamo la ketso ena. Fast-tshwere inducer ea e se nang sesosa interferon

Ka morero oa ho thibela le kalafo ea mafu a bongata ba kokwanahloko interferon inducers sebediswa. mochine oa bona oa ketso e amanang le tsoelo-pele ea protheine dintho hore thibela le katiso ea likokoana-hloko. thehiloeng inductors lithethefatsi ka loantša mafu a matšoafo, herpes le tšoaetso ea e amanang le sebete le ntaramane.

Boikemisetso ba interferon

Ho joalo le ka sehlopha sa metsoako le hlahang ho yona protheine. Ba hlahisa lisele tse tšoaelitsoeng ke likokoana-hloko ea vaerase.

Interferon dintho na le mabaka a bao e seng e itseng mochine tshireletso 'meleng khahlanong le baktheria, chlamydial, nkang monyetla fungal, mehaho e hlahala seleng. Ba boetse li phetha karolo ea balaoli ba intercellular ditshebeditsano maloetseng systemic. Ba ba bitsoa immunomodulators le mofuta e se nang sesosa.

Ho na le liforomo tse 'maloa tsa interferon dintho batho leukocyte kapa a-interferon, fibroblast, kapa b,-interferon,' me sa 'mele kapa ho g,-interferon.

Driving mochine ho sebetsa e qala ka liprotheine e tlamang le receptors liseleng tsa mofuta o itseng. Ha e joalo e sebelisana ba tsa maiketsetso limolek'hule protheine ka har'a ba mashome a mararo. Le tlhotlheletso ya peptides taolo etsoa mosebetsi oa T-lymphocytes le mehaho macrophage-mofuta o hlahellang thibela ingress ea likokoana-hloko ka lera sele le ho ikatisa tsa bona. Ho ba ba nang le boikarabelo ba ho thepa e sireletsang.

Natural interferon inducers - ka lisele tse bongata ba kokwanahloko e li ikhakantse ka 'mele o phelang. Ba matla le ba fokolang stimulators tsa tlhahiso ea liprotheine e sireletsang. Boholo ba mahlahana a mafu a bo tebileng boo ba inducers mafutsana. Tsena li akarelletsa cytomegalovirus le HIV, herpes, hepatitis C le foromo B Empa ba bangata ba likokoana-hloko le tse bakang ho hema mafu bongata ba kokwanahloko, li nkoa stimulators matla ea ho hlahisa liprotheine sireletsang.

Interferon inducers (lithethefatsi): e leng sona

Ka tloaelo ho e bua ka sehlopha sa ba a maiketsetso a lithethefatsi immunomodulators. Di hlahiswa ke lik'hamphani meriana. Interferon inducers (lithethefatsi) ba Ranked ka sehlopha sa kgolo ya fapaneng sebopeho lik'hemik'hale tsa metsoako eo. dikarolo Active ka 'na ba tlaase' me e phahameng-limolek'hule ntho, e hlahang ho yona maiketsetso kapa likoluoa tsa tlhaho. Ba abelana tšobotsi e tloaelehileng, eo dumella hore 'mele ho susumelletsa ka lisele tsa hao, kapa e se nang sesosa interferon. litokisetso tse joalo ho ka bontša antiviral le immunomodulating se nang matla.

Kamoo u ka sebelisang

Inducers ea e se nang sesosa interferon - litokisetso Sepheo, maemong a mangata, ho loantša tšoaetso ea bongata ba kokwanahloko. The mochine tsa ama batho bona bo thehiloe ho ikopanya le motho ea mafolofolo ntho lithethefatsi dikahare lisele le dinama tse nyenyane tse e leng se ka hlahisa protheine e sireletsang.

Interferon inducers - meriana tlhaho tse ntlafatsa ho itšehla thajana tsa protheine ea artificially. le phello ea bona e tshwanang ya tse susumetsang tsa tlhaho, tse akarelletsang bongata ba kokwanahloko, baktheria lisele le dintho tse sa tšoaneng.

Tshebediso ya inducers interferon ka etsa hore hyporesponsiveness. Ka puso ena, holim 'a pheta tsamaiso ea moriana e ke ke ea hore ba be le sireletsang e le karabelo protheine, o ile a re hatelloang lona. Mothating ona sebetseng ho o laola ka lithethefatsi. Ka nako ea puso ena e laolwang ke inductor ena. Phetoho ea motsoako o sebetsang, hammoho le tšitiso ea kalafo le thuso e tšoanang moemeli ho felisa hyporesponsiveness.

Kgetho ya lithethefatsi tse susumelletsang hore tlhahiso ea protheine sireletsang hase eena ea bakang boholo litla bohloko hlokang tlosa bona.

Ka ba molemo ho inducers ea e se nang sesosa protheine

Ho na le ditsela tse pedi tsa ho ntlafatsa maloetseng interferon. komponeng Sena se ka ho tsamaisoa ka ho toba kapa exogenously ka ntho e phelang. Tsela e 'ngoe e akarelletsa interferonizatsiyu e se nang sesosa ha ho qaloa ho dintho hore susumelletsa ho hlahisa interferon lona. protheine ena e bontša se na antigenicity, leo e seng la recombinant interferon. Nako e telele tsamaiso ya lithethefatsi tse felileng protheine isang ntshetsopeleng a itšoare boima.

Inducers ea e se nang sesosa interferon ho ithuta katleho bona o ile a bontša mosebetsi diokobatsi ka manyenyane sephara ea tšoaetso ea. Ho ile ha fumanoa thepa ea bona bifunctional, tšoauoa ka e le hantle phatlalletsoang antiviral, le immunomodulating sebediswa.

Ketso ea inducers interferon isang ho tswakana ea lihaha-'mele, eo ka eona mesebetsi ea bona joaloka liprotheine itokiselitse ho sireletsa. tšebetso e joalo e leka-lekaneng, taolo lona mekgwa eo ka tsela e atlehang sireletsa phelang ho tswa sebopeho ka tsela e feteletseng ea metsoako ena.

Ka kopo e le 'ngoe ea litokisetso susumelletsa interferon ke ka toka nako e telele ajoa tsa protheine le sireletsang hlokahalang phekolo lethal dose. Ho fumana e joalo e litekanyetso li behoa ka ho khethoa e le protheine exogenous lokela ho pheta-pheta tsamaisoa ka meqolo e kgolo. kalafo ena e nkoa e le e theko e boima ho feta.

Lethathamo la lithethefatsi

Hona joale, lingaka tse eketsehileng u sebelisa interferon inducers - lithethefatsi tse thathamisa selemo le selemo phaella ka ho re meriana e ncha. A palo e kholo ea immunomodulating mahlahana a lumella u ho loantša mafu a tse ngata.

Jwalo ka karolo ya boitshireletso ba mmele ba teng le ka tshebediso ya kokangana dikarolo tseo phetha ho felisoa ha e sa tloaelehang phelang hlahang ho yona metsoako antigenic. E mong le e elements o itseng mahlahana a 'mele. Sena se hlalosa mefuta-futa e ya dihlahiswa eo kenya letsoho hore ho ho hōla ha protheine e sireletsang.

Ho na le inducers tse fapa-fapaneng interferon (lithethefatsi), lenane la tseo e eteletsoeng pele ke sethethefatsi "Poludan". sesebelisoa sena se nkoa e le stimulator liprotheine pele sireletsang, eo ba ile ba qala ho sebediswa esita le ka 70s ea. Ho akarelletsa ho poliuridinovaya le asiti polyadenylic. katleho ea eona e ho ntshetsa pele interferon nyenyane. Leihlo marotholi le liente tsa lithethefatsi "Poludan" tšoara herpetic keratitis le keratokonyunktivity. tharollo ea lithethefatsi etsang dikopo tsa ho phekola herpes vaginitis le vulvovaginitis.

Interferon inducers - lithethefatsi "Aktaviron", "Lavomax", "Tilaksin" "dihydrochloride tilorona", "Amiksin", "Tiloram" - ka sebopeho le na le motho ea mafolofolo motsoako o tilorona.

Lithethefatsi "Ridostin" le "sodium letsoai ea acid e habeli-tsielehile ribonucleic" etsoa le sodium ribonukleat o emelang ntho.

ntho umifenovir akarelletsa "Arbidol" meriana, "Arbivir", "Immustat" le "Arpeflyu".

Ho na le hape interferon inducers, lithethefatsi tse bitsoang ka lebitso la dintho e sebetsang. Tsena li akarelletsa "Kagocel" matlapa a le "tilorona".

Thehiloeng akridonatsetata meglumine etsoa moriana "Meglumine akridonatsetat" le "TSikloferon" le oksodigidroakridinilatsetat sodium se teng ka lithethefatsi "Neovir".

Ea ho hlophisoa le bolela "Jodantipyrin" le akarelletsa 1-phenyl-2,3-dimethyl-4-yodpirazolon, 'me ka "Alpizarin" matlapa a leng magniferrina letsoai.

Inductors interferon bakeng sa bana, tlhaloso ea bona

Ho na le ba bangata ba batho ba baholo meriana e ka fuoa ngoana, empa feela ho le lilemong tse itseng. Ka mohlala, lithethefatsi "TSikloferon" ba qala ho tšoara lilemo selemo tse 'nè,' me le bolela "Ridostin" ea khethiloeng ke le lilemo li supileng. lithethefatsi bobeli na e mengata e fapaneng liphello. Ba a loketse bakeng sa ho phekola mafu a matšoafo a tlhaho bongata ba kokwanahloko, puso ntaramane, lefu la sebete sa foleng, lefu herpes. mosing bona ke khoneha rateheng lehlakoreng liphetoho.

Interferon inducers - litokisetso eo li etselitsoe ka ho toba bakeng sa bana foromo khetheha ngwana. "Arbidol" E mong oa bona ke mokhoa. E e sebediswa ka a le lilemo li peli. Bana ba moriana o foromo etsoa ka mokgwa wa capsules bakeng sa tsamaiso hare. ba lokisetsa ho ea a nang le tsona litla antiviral le immunomodulatory.

E amana le mahlahana antiviral hore thibela metsoako kokoana-hloko seleng ea B le mofuta A. Ka ho ba le seabo hae susumelletseha tlhahiso ea interferon hare, e thibela ho ikopanya le ho kenella ka hare ka tšoaetso ea seleng ea ka. Tlas'a ketso ya ho sireletsa lipid bongata ba kokwanahloko enfelopo protheine e sa khone ho amahanya le lera seleng.

Interferon inducers bana tlatsetsa ho eketsa a itsireletse maloetseng ea humoral mofuta ka bohato 'mele ea bona e ba manganga ho feta ho mahlahana a tšoaetsanoang, fokolitse palo ea la mathata.

Lithethefatsi "Kagocel" e na le phello e tšoanang 'mele oa ngoana. E ya hlahiswa ka mokgwa wa matlapa bakeng sa ho sebelisoa ka hare. Age moedi tšebeliso ea lithethefatsi - ka lilemo tse tharo.

Kalafo ea mafu a matšoafo

Interferon inducers - lithethefatsi ho tšoara SARS, e lebisa hore ho thehoe ka lisele tsa phelang protheine e sireletsang. Ba ne ba boetse ba khethoa le ho kula ntaramane.

Mokhoa atlehang ka ho fetisisa li nkoa meriana thehiloeng tilorona, tse akarelletsang lipilisi "tilorona" le "Amiksin". Bakeng sa kalafo ya ntaramane le mafu a hlobaetsang le ho hema bongata ba kokwanahloko e kgothaletswa ho sebelisa motho e moholo ka hare ho 125 mg, ka nako. lethal dose ena e ajoa ka matsatsi a mabeli pele, ha ntan'o 125 mg, nkiloeng ka letsatsi le leng. Course palo ya moriana o ke 750mg.

Bakeng sa ho phetha mehato e thibelang e ka sebediswa ke 125 mg, ka nako, ebe ka mor'a matsatsi a 6 theoha. etsa joalo e pheta ka libeke tse tšeletseng.

thehiloeng lithethefatsi tilorona ba contraindicated a mamellane jaana motho, nakong ea bokhachane 'me ha a ntse a ea matsoele-ho fepa lesea la hao.

Fumana meriana e joalo ho ka etsa hore ho nyekoa ke pelo, feberu, alejiki itšoara joang.

Ho lokisetsa "umifenovir" o interferon-ho susumelletsa mosebetsi, tlhotlheletso ya lisele mofuta maloetseng, ho matlafatsa botsitso ba phelang kaofela ho mahlahana a tšoaetsanoang.

Ka mehato e thibelang e ka ha a kopana le batho ba kulang e beuweng lethal dose ea letsatsi le letsatsi ea 200 mg, beke e 'ngoe. Nako ka linako tse itseng tsa ntaramane le mafu matšoafo sebelisa lethal dose ea letsatsi le letsatsi ea 100 mg, ka nako e itseng, ka nako eo etsa khefu bakeng sa matsatsi a mabeli. Ke 'nete hore sena se nka libeke tse tharo. Bakeng sa kalafo ya sefuba abeloa 200 mg, ka makhetlo a mane ka letsatsi, ka matsatsi a mararo.

Lithethefatsi le umifenovir ha sebelisoa ka ho se mamellane jaana motho nakong haholo somatic malwetse. Amohela meriana e joalo ho ka etsa hore kulisa.

Kalafo ea mafu a autoimmune

mafu a joalo e kenyeletsa e re pathological oo hlahisa lisireletsi kapa atisa autoaggressive clones molai seleng ea ka lebaka la dinama tse nyenyane tse phetseng hantle. Sena se etsa hore ho senya le ho timetsoa ha dinama tse nyenyane tse phetseng hantle, le ka lebaka la e leng autoimmune ruruha.

Ka tloaelo sebediswa ea ho phekola ba inducers interferon. Formulations tsamaisoa ka mafu autoimmune, ba nang le bohato immunosuppressive.

Bakeng sa ho phekoloa ho sebelisa lithethefatsi ke multiple sclerosis hasane "Amiksin". Ka matšoao feela oa hlobaetsang matšoafo tshwaetso tlhaho, tseo aggravates boemo abeloa lethal dose ea 125 mg, kapa 250 mg, ea lithethefatsi ka mor'a hore a e-ja. Tablets noa ka letsatsi, tsa mokete oa nako - ho tloha matsatsi a 6 ho 12.

Bakeng sa thibelo ea hasana sclerosis exacerbation abetsoe 125 mg, ea moriana, makhetlo a 2 ka matsatsi a 7.

Ha e rarahaneng ya mohato mafolofolo tsa lefu lena le ho tšoara matšoao o teng ya meriana a hlobaetsang le nkiloe ke 10 ho 125 mg, mong le e mong matsatsi a 30 likhoeli tse 6. Ho lokisetsa "Amiksin" abetsoe le peptide bioregulators kakaretso e le hantle eo ho fokotsa nahanela ea 'mele ea ho eketseha myelin protheine.

Kopantswe phekolo lithethefatsi "TSikloferon" lumella u ho loantša jete le ramatiki le ruruhisang, mafu systemic amang lisele connective. mosebetsi oa hae o ikemiseditse ho ea hatelloang tsa dithulaganyo autoimmune, eo e fana ka-ba khahlanong le a hlabang le analgesic phello ea tlhaho. Ho sebelisa mekhoa e laolwa boemo boitshireletso ka bopengwi a sa tšoaneng immunodeficient. "TSikloferon" lithethefatsi e hlahisoa mofuta o letlapa, ka mokgwa wa tharollo injectable le liniment.

Bakeng sa kalafo ya ramatiki lithethefatsi o laolwa entoe kapa intramuscularly 1 nako ka letsatsi. The litekanyetso li behoa ea 250 mg, sebelisa pele ka letsatsi bolesomepedi ka matsatsi a esita le. Ka mafu a hlobaetsang le ho sebetsa e ile ea eketseha lethal dose ea pele ea 500 mg,.

Phekolo ea Mafu a bongata ba kokwanahloko

Lithethefatsi "Amiksin" e bolela interferonovym inductors fluoreonovogo boima sehlopha sa tlaase ea limolek'hule. Ka ho ba le seabo hae thehoa tsohle mefuta ya liprotheine sireletsang, eo boemo ba ka letsatsi le leng ka mor'a ho sebelisa moriana o fihla boleng lona phahameng ka ho fetisisa lero la mali e.

moriana o na le mefuta e fapaneng e khōlō ea bohato antiviral. Ho phaella ho lefu ho hema, le sebelisitsoe ka hepatitis C le a hlobaetsang le a sa foleng, e iphetang herpes genital, tshwaetso cytomegalovirus le mofuta chlamydial.

Tse ngata antiviral lithethefatsi - inducers interferon, ha ho na le mokhelo ke mokhoa oa ho "Neovir". Ka ho ba le seabo hae, se hlahisa e khōlō palo ya le protheine e sireletsang, haholo-holo fibroblast-mofuta, e hlalosa immunomodulatory,-ba khahlanong le bongata ba kokwanahloko le-ba khahlanong le hlahala e le hantle ea lithethefatsi ena. Lithethefatsi "Neovir" tsoara ho ruruha ha boko, hepatitis C le B, urethritis, cervicitis, salpingitis bakoang ke Chlamydia.

E mong inducer tšoanang tsa protheine sireletsang ke tlaase limolek'hule boima lithethefatsi "TSikloferon", tse sebediswa bakeng sa tswakana karboksimetilenakridona methylglucamine letsoai. Ka ho ba le seabo ha thehoa hae, alpha interferon, diteng tsa e leng e bolokwa ka dinama tse nyenyane tse lymphoid ka matsatsi a mararo.

B lymphocytes T le macrophages B-mofuta ke sebopeho sa e le sireletsang le protheine Tshebediso ya ka dibopeho boko bakoang lesapo, tlhotlheletso ya tlhahiso ya diyuniti granulocyte. Lithethefatsi le sebelisitsoe ka letshwao-jere ho ruruha ha boko, herpes, lefu la sebete, cytomegalovirus, batho immunodeficiency kokoana-hloko le papillomas.

Ho ekelletsa moo antiviral kgahlamelo ya maqhubu a ho bolela o mosebetsi ka a hlobaetsang le a sa foleng baktheria chlamydia, ho ruruha erysipilatous tlhaho, la bronchitis, mathata postoperative, tšoaetso genitourinary, diso ulcerative.

E ne e bonahala ka 'marakeng e le lithethefatsi meriana "Lavomax' hlahisoa" Nizhpharm "hona joale. Ho ba le phello immunomodulatory, ba nang le bokhoni ba ho susumelletsa interferons, antiviral e le hantle e mengata e fapaneng le leholo.

E le karolo ea "Lavomax" matlapa a leng 125 mg, tilorona e le motsoako a sebetsang. Lithethefatsi ke manaka a lithethefatsi "Amiksin". mosebetsi lona e lebisitsoe ho tlhotlheletso moloko oa mefuta e meraro ea interferon ka T-lymphocytes, hepatocytes, lisele tse epithelial ea leboteng mala.

Tšusumetso ea immunomodulating litla e loketseng ho tsosolosa teka-tekano pakeng tsa lisele tse ba mmele le tlwaelegileng a ea tlhahiso antibody. Motheong oa mochine oa mosebetsi antiviral ke thibelo ea protheine tswakana, likokoana-hloko tse itseng libakeng tse nang le tšoaetso ea 'mele. Sena tlōla ho ikatisa tsa bona ka ho eketsehileng.

Ntaramane-joaloka lithethefatsi ho ka katleho tšoara boemo, maloetse, mofuta matšoafo, bongata ba kokwanahloko lefu la sebete le herpes lekhopho.

Inductors bohato kgaoletsang

Ka kakaretso, tsamaiso ya meriana joalo isang tieo ntshetsopeleng ya protheine e sireletsang.
Fast-a sebetsa ho inducer ea e se nang sesosa interferon ka hare ho lihora tse seng kae tsa ho lula 'meleng ho ka etsa hore ho thehoe le protheine e bontšang katleho ea bona.

tilorona ntho eketseha ka mor'a ho sebelisa ka hare ho tsepamisa mohopolo protheine ho fihlela ka boleng lebetsoeng le se mora 4 H. Ho na le ke sebopeho butle-butle interferon ka intestine pele, lateloa ke sebete 'me bosiu - maling.

Ho lokisetsa "TSikloferon" bitsang protheine ka mor'a lihora tse 4, 'me tlhōrō e ketekoa ka mor'a lihora tse 8, ka mor'a moo ho na le ea fokotseha butle-butle ka mahloriso.