Ea gamma-interferon: karolo le bohlokwa ka 'mele oa motho

Ho sireletsa 'mele oa motho liphellong tse senyang tsa likokoana-hloko - likokoana-hloko, ho na le mochine ka boitshireletso ba mmele, ho fana ka taolo ya mafu a tšoaetsanoang. Ke lisele tsa tlhahiso, tse kang T-lymphocytes dintho itseng, e 'ngoe ea tsona e sa gamma-interferon. Eaba ba etsa ka boitshireletso ba mmele, mabapi le sebetsang sebakeng sa hae e le tshireletso ya lisele. Ke hobane'ng ha e le habohlokoa hakaale ka setšoantšo, le ka motheong ofe tla botšepehi ba 'mele ea rōna - lipotso tsena li tla arajoa sehloohong sena.

Sebopeho lik'hemik'hale le ho amohela

Motheong oa ntho e - e glycoprotein - amanang peptide k'habohaedreite. Biochemists abelwa mefuta e 'meli sa tšoaneng amino acid e sebopeho 139 le monomer pele ka ketane polypeptide. Ba ba bitsoa ea gamma-interferon 1a le 2a. The limolek'hule boima karolelano ea ka taelo ea 20 - 25 kDa. Thehoa ha le arabela ka ho kenella ka hare ea lisele le lisele tsa moemeli pathogenic emeloang likaroloana bongata ba kokwanahloko. Ka vitro ntho fumanoa ka theknoloji ea baeloji le fetola liphatsa tsa lefutso ho sebelisa mefuta e baktheria ya Escherichia coli, e plasmid eo e na le liphatsa tsa lefutso bakeng sa interferon batho. Ena ea gamma-interferon bitsoa recombinant ke karolo ea litokisetso: "Immuneron" "Ingaron" "Immunnomaks".

The mochine oa likarabo boitshireletso

Ponahalo ea 'mele oa mojaki likokoana-hloko virulent kamehla tsamaea le tsamaiso ea dithulaganyo sireletsang, e' ngoe ea tseo ke ho ruruha. E sebeletsa e le lesupa le, a bontša hore e le qalo ea lefu hammoho le ka karabelo seleng ea arabela antigens tsa pathogen ena. Ho na le ke sebelisana rarahaneng pakeng tsa boemo ba leholimo ba dinama tse nyenyane tse ea nang le tšoaetso, kapa lekala. E thehiloe dintho tse hlahisoang ke lisele tse sa dinama tse nyenyane tse lymphoid: ea tse ling (lymphokines). Mohlala, lisele tse batho interferon-ea gamma, interleukin 2 ke phehella ditshebeditsano lera ha tshwaetso qala ho tswakana tsa lisireletsi, 'me ba hantle a hoehla liprotheine. A re hlahlobeng bona ka ho qaqileng.

thepa lymphokines

The batho chromosome 6 para teng locus se se akaretsang sete ya liphatsa tsa lefutso, a phethang tlhahisoleseding e mabapi le ya thepa antigenic tsa lera lero la mali 'me organelles tse ling lisele: motheo, mitochondria, joalo-joalo Lymphokines ha a khone ho kotloloho susumetsa antigens ya likokoana-hloko, empa ka potlako fetisa boitsebiso bo mabapi le ho ba teng ha dintho baditjhaba seleng e 'ngoe ho' ngoe. Ka mohlala, receptor ea lisele antigen-mothusi le T-lymphocytes Tor bitsang e pontšo intracellular, tse peli tse itseng activating protheine. Ho feta moo ka le dinama tse nyenyane tse lymphoid e ntlafatsoa mitotic karohano thulaganyou e - ata, 'me maloetseng a ka cell-go ranolelwang kwa e eketsehile haholo. Joalokaha eka ke ka lymphokines a mang, interferon-ea gamma thibela le thulaganyo ya khopi ya acid e bongata ba kokwanahloko nucleic, 'me hape thibela kopano tsa mochine oa limolek'hule tsa protheine pathogen. Re ka bolela hore metsoako protheine, ho nkoa ka ho re, ke motheong oa maloetseng humoral.

Joang boitshireletso ba mmele

Thymus, lisele tsa mmele nodes, tonsils, sehlomathiso - sebaka lymphocyte sebopeho. lisele tse sireletsang hlahisa lisireletsi hore thibela metsoako ntshetsopele ya mmele se hlahang ho yona tšoaetsanoang. Ka mekhahlelo ea pele ea ho hōla ha lisele tsa sesole sa 'mele e bitswang khongoana holimo, a ke ke boloka tlaleho ea antigens tsoang linaheng tse ling, libaktheria le likokoana-hloko. Ba lokela ho hōlileng ka ho feletseng 'me e be immunocompetent - e le hlaha ka thymus ena. Tsamaiso ea phelang hore e hlahisa bobeli lisele tse ipatlele tshireletso: macrophages, lisele tse T, lisele tse 'molai, hammoho le mefuta e sa tšoaneng tsa gamma-interferon tlas'a taolo ea litsi phahame cortical ea boko.

mosebetsi lona le boetse le laoloa ke litsoelesa adrenal, pituitary tšoelesa le hypothalamus. Tsehetso ea hlabollo-maikutlong maloetse, phepo e nepahetseng mafutsana le mekhoa e mebe fokotsa itsoara joang ka boitshireletso ea 'mele, hangata ka ho fetisisa e le hlaha ka semelo sa khatello ea kelello bo sa foleng. Ho tloha ka karabelo ea phelang ke ka lebaka la liketso tsohle tsa tsamaiso ea lona, leha e le efe khahlanong le homeostasis boitshireletso tletse lintho tse ngata ho hlōleha le ho fokolloa ke bophelo.

Lisireletsi ho interferon batho ea gamma

Ikatisetsa ya kalafi ka prophylactic le phekolo moemeli sebediswa dintho tse nang le lihaha-'mele le sireletsang hlahisoang ke entoa ea liphoofolo le interferon recombinant. limolek'hule Antibody tseko tloha serum mali, ho hloekisoa le ho sebelisoa e le sethethefatsi se antiviral. Ke khona ho ntlafatsa mosebetsi oa metsoako ea 'mele ea ipatlele sireletsang, mohlala, ea gamma-globulin,' me hape ho fokotsa matšoao a tšoaetso ea matšoafo: rhinitis le nasal tsubuhlellano, khohlela.

Phello phekolo ea interferon

glycoprotein sireletsang thibela katiso ea likokoana-hloko 'me di hlohleletsago enzyme seleng, tse kang protheine kinase adenilatsintetazu le ho fana ka tse hatelloang tsa tswakana ea acid nucleic le liprotheine tsa enfelopo le bongata ba kokwanahloko. ntho e na le matla a ho susumetsa ba nahanela liprotheine lera ho lymphokines seleng ea ka, 't. E. Na immunomodulators. Ea gamma-interferon bakeng sa bana le batho ba baholo e sebediswa bakeng sa ho thibela le kalafo ea mafu a tsoaetsanang ntaramane le ho hema, le disampole positive, bakeng sa ho ba teng ha bacillus Koch ka 'mele. The moemeli phekolo e lokolloa ka mokgwa wa matlapa, ditlotso, suppositories le liente.

The tshebediso ya lithethefatsi e balletsweng ke ngaka, bana ba ka qala ho tswa ho likhoeli tse 6, fuoa lebaka la ho hloka liphetoho ngoana oa alejiki le pathologies bo tebileng boo ba tsamaiso ea pelo le methapo. Contraindication ho kalafo ya basali ke ho ima le allergy. lithethefatsi hona joale haholo-holo sebelisoa ka Pediatrics, na le sireletsang recombinant protheine le ho hloka sekoli phahameng le ho ba sieo ka ho feletseng likhechana polypeptide.