"Розувастатин": thuto ea kopo, likarabo. Cheap analogue of "Khabarovsk"

Meriana e bitsoang "Rosuvastatin" e tsejoa ho tloha ka 2003 'me e fanoa e le statin ea moloko oa IV. Ke mokhoa oa morao-rao oa boleng oa metha-methylglutaryl-CoA reductase. Enzyme ena e ikarabella bakeng sa ho qeta k'holeseterole 'meleng oa motho. Tšitiso ea eona e lebisa ho fokotseha ha k'holeseterole e sa feleng le ho fokotsa kotsi ea ho ba le lefu la pelo.

Ho phaella ho "Rosuvastatin," ho na le litšoantšo tse ling tse 'maloa tsa lihlopha tsa sehlopha sa statin. Tsena ke Simvastatin, Pravastatin, Cerivastatin, Lovastatin, Fluvastatin, Atorvastatin, le Pitavastatin. Ho ea ka katleho ea bongaka le tekanyo ea ho fokotseha ha k'holeseterole e fokolang le e tlaase, "Rosuvastatin" ke ea bobeli feela ho "Pitavastatin", e sa sebelisoang haholo ka lebaka la ho fokolloa ha lithuto tsa bongaka.

Ho fihlela joale, "Atorvastatin" e sebelisoa hangata ho feta li-statine tse ling ka lebaka la hore e na le motheo oa lipatlisiso ka ho fetisisa oa bopaki ba katleho ea eona ea bongaka. Eena le li-generic tsa hae li boetse li theko e tlaase ho feta Rosuvastatin. Empa kaha phello ea ho qetela (ho tloaeleha ha boemo ba lipilisi ea mali a mali) e potlakile, joale e qala ho sebelisoa haholoanyane. Ha e le hantle ke lithethefatsi tsa boleng, tseo u lokelang ho lefa theko ea tsona.

Sebaka "Rosuvastatin" ho pharmacotherapy

Tokisetso ea "Rosuvastatin" e sebelisa, ho sa tsotellehe boteng ba li-analogs tsa lihlopha, ho e-na le ho lekana. E thehiloe ka matšoao 'me e lekane ho li-contraindications. Lipontšo ke hoo e batlang e le mefuta eohle ea hypercholesterolemia le tlōlo ea mafura a metabolism. Ka nako e ts'oanang, ho fokotseha ha likaroloana tsa lipilisi ho na le phello e ntle 'meleng. Ka lebaka la sena, menyetla ea ho hlaolela lisele tsa atherosclerotic e fokotseha, 'me nako ea bophelo (le boleng ba eona) e eketseha ka tsela e itseng.

Meriana e bitsoang "Rosuvastatin" e ka sebelisoa ka bobeli ho thibela maloetse a pelo, le bakeng sa phekolo ea bona. Niche ea ho qetela ea pharmacotherapy e bakoa ke thibelo ea atherosclerosis le botsitso ba endothelium holim'a lejoe. Kaha tšoaetso ea lefu la pelo le ea pelo e bakoa ke ts'oaetso e matla ea methapo e etellang pele, phello ena ea kliniki e hlile e thusa ho thibela liketsahalo tse hlahelang.

Litaelo tsa tšebeliso

Tse khomaretsoeng ke lithethefatsi "Rosuvastatin" litaelo tsa tšebeliso (lipapiso tse joalo tsa litokomane ha li fumanehe) li na le melaetsa e fokolang ea litlhahiso tse sebelisoang. Leha ho le joalo, ha e na boitsebiso bakeng sa mokuli hore pele ho kopo ho hlokahala hore ho khethoe likaroloana tsa k'holeseterole. Nakong e tlang, phetoho ea bona e tla lumella ho hlahloba katleho ea bongaka ea phekolo ka tekanyo e itseng. Hape, thuto e na le tlhahisoleseding mabapi le mekhoa ea ho itšireletsa le likarolo tsa kalafo, ka li-contraindications le litla-morao tsa bohlokoa ka ho fetisisa le tsa bohlokoa.

Lipontšo tsa tšebeliso

Har'a maloetse 'ohle a amanang le likaroloana tse ngata tsa lipid tsa mali, ho na le lintlha tse ling tse fumanoang ka kliniki:

• Heterozygous e nang le lihlahisoa tsa malapa (lelapa) hypercholesterolemia;
• Fredrickson classified polygenic hypercholesterolemia mofuta wa IIa;
• Dyslipidemia e kopantsweng e hlalositsoeng ke Fredrickson e le IIb;
• Homozygous hereditary (lelapa) hypercholesterolemia;
• Coronary, lefu la ts'oaetso ea masapo kapa lefu la renal, e hlahisang lumen ea artery;
• Matšoao a likokoana-hloko a methapo ea maoto e tlaase, ho akarelletsa le Lerish's syndrome ;
• Hypertriglyceridemia (mofuta oa IV ho latela Fredrickson);
• Phekolo ea lefu la likokoana-hloko le boko, ho qala ka nako e thata;
• Ho thibela tšoaetso ea likokoana-hloko le stroke.

Litlhōlisano

Mofuta o mong o theko e tlaase oa "Rosuvastatin" o na le litla-morao tse lekanang le "Crestor" ea pele. Motheong oa bona ho thehoa mekhoa e mengata ea ho hanyetsa, e shebahala joaloka ena:

• Lefu la sebete le cytolysis ea hepatocyte le ho eketseha ha makhetlo a fetang a mararo mokhoeng oa transaminase;
• Ho se sebetse hantle, ho thatafala ha sebete sebeteng ka lintlha tse 9 ka tekanyo ea Child-Pugh;
• Ho hloleha ha nako e telele ho ts'oaetso ea renal ka tumello ea tlhahiso ea creatinine tlase ho 30 ml / min;
• Myopathy ea tšimoloho leha e le efe;
• Liphetoho tsa litlama ho likarolo tsa feshene kapa "Rosuvastatin".

Ho na le sehlopha sa litlhaloso tse eketsehileng tsa tekanyo ea 40 mg:

• Ho hlōleha ha renal ka nako e telele ka tumello ea bonyane bonyane 60 ml / min;
• Myopathie leha e le efe ea lefutso;
• Ho amoheloa ka nako e le 'ngoe ka fibrate;
• Ho noa joala;
• Peiso ea Mamongolia;
• Tšebeliso ea statin ka lekhetlo la pele.

Likarolo tsa lithethefatsi

Tsohle "Rosuvastatin" - litokisetso, tse tšoanang le tsona tse emetsoeng marakeng. 'Me, ha a khetha lebitso le itseng la khoebo, mokuli o lokela ho noa meriana ena. Ke hore, ho fetola meriana ea e mong ke ntho e sa utloahaleng. Moriana ka boeona o nkoa ho sa tsotellehe lijo le nako leha e le efe ea letsatsi. Ho na le litlhahiso tse ling tse seng kae tsa litsebi tse ileng tsa sebetsa le li-statin tsa meloko ea pele. Li na le tlhahisoleseding eo u lokelang ho e nka ka li-statins pele u robala. Le hoja sena ke sa bohlokoa haholo, ntho ea bohlokoa ke hore meriana e lokela ho nkoa ka nako e le 'ngoe le kamehla.

Itlhokomele boemo ba hao kamehla, ha "Rosuvastatin" (litšoantšo tse tšoanang) e amoheloa. Tlhaloso ea litsebi e re lumella ho etsa litsela tse ntle ka ho fetisisa tsa ho shebella. Ka ho khetheha, ka mor'a ho theha boteng ba hypercholesterolemia, o lokela ho qala ho noa moriana ka tekanyo e tsitsitseng. Kamora likhoeli tse peli, taolo e etsoa - lipidogram e phetoa khafetsa mme mosebetsi oa aminotransferases o hlahlojoa.

Haeba boemo ba lipilisi tsa mali bo hlokomoloha, ho hlokahala hore ho tsoele pele ho nka tekanyo e le 'ngoe. Haeba k'holeseterole eohle e ntse e phahame, 'me boholo ba k'holeseterole e tlase butle-butle e fokotseha hanyenyane, keketseho ea tekanyo e hlokahalang. Haeba li-transaminase li eketseha ka makhetlo a mararo, li-statins li lokela ho tlosoa. Ke habohlokoa hore re hlokomelise haholo hore mocheso o monyenyane oa ho etsa hore cytolysis e hlahisoe ke statins kaofela ke "Rosuvastatin." Li-analogues (Ukraine e boetse e tloha butle-butle ho tloha "Atorvastatin" ho "Rosuvastatin") ka tlelaseng ha e sireletsehe haholo. 'Me tse nyenyane tse ithutoang ke "Pitavastatin".

Li-analogue tsa "Rosuvastatin"

Joaloka lipapiso tsa "Rosuvastatin" ("Crestor") e se e ntse e le teng kajeno ho etsoa litokisetso tse fetang 10. Har'a bona, "Acorta", "Mertenil", "Rosart", "Rosystarc", "Rosuvastatin Canon", "Rosuvastatin Soteks", "Rosuvastatin SZ", "Rosulip", "Rosukard", "Roxera", "Rustor" Tevastor ". Theko ea phekolo ea bona e fapane, joalo ka ha e sebetsa hantle. Theko ea lithethefatsi tsena e ka aroloa likarolo tse tharo:

• Litheko tse tlaase (ho tloha ho li-ruble tse 250 ho ea ho tse 650): "Rosuvastatin SZ", "Rosuvastatin Kanon", "Acorta", "Rosuvastatin SOTEX";
• Karolelano ea theko (ho tloha ho li-ruble tse 400 ho isa ho 900): "Mertenil", "Rosart", "Roxera", "Rosukard", "Tevastor", "Rosulip";
• Litheko tse phahameng (ho tloha li-ruble tse 1100 ho ea ho 2200): "Moela".

Tlhahlobo ea theko e ne e etsoa ka lebaka la papiso ea theko ea litokisetso, boholo ba ntho e sebetsang eo ho eona ho neng ho e-na le 10 mg. Mefuta ea thekiso e bontša litšenyehelo tsa khoeli ea likhoeli tse le mong ea phekolo ea hypocholesterolemic. Analogue e theko e tlase ea "Rosuvastatin" e hlahisoa ke khampani "Northern Star". "Rosuvastatin Canon" le "Akorta" le tsona li fapane haholo ka theko. Litsenyehelo tsa bona li fapana ho fokolang ho itšetlehile ka ho fetoha ha lichelete.

Tlhaloso ea "Krestor" e theko e tlaase

Moriana o bitsoang "Rosuvastatin", o lokollotsoeng ke Astrazeneca, o bitsoa "Crestor". Ena ke meriana ea pele, eo bohle ba lokelang ho bapisoa le eona. E tšoanang e ea bakeng sa maikutlo: sebopeho sa lithethefatsi tse itseng tsa tlhaho li lokela ho thehiloe ho bapisoa le "Krestor." Empa ka lebaka la litšenyehelo tsa eona tse phahameng, bakuli ba bangata hang-hang ba qala ho phekoloa ka hypercholesterolemia ka lihlahisoa tse theko e tlaase.

Boitsebiso bo nang le sepheo ho lihlopha bo ka fanoa feela ke litsebi tse atisang ho kopana le "Rosuvastatin" e tloaelehileng, le "Crestor" ea pele. 'Me ho kopantsoe le lithethefatsi "Rosuvastatin" litaelo tsa tšebeliso, maikutlo a mokuli le phihlelo ea bongaka e tla lumella bakuli ba bang ho khetha lebitso le itseng la khoebo.

Tlhahlobo ea Litsebi tsa "Krestore" le tsa generic

Ho bapisoa ha "Krestor" ho ne ho etsoa feela ke litsebi tsa Mokhatlo oa All-Russian of Cardiology. Boitsebiso bona bo atisa ho hatisoa koranteng ea Rational Pharmacotherapy ka Cardiology. Haholo-holo, e ama lipotso tsa li-bioquivalence tsa li-generic ho ea lithethefatsi "Krestor". Ho ea ka liphello tsa lithuto tsa pharmacoeconomic ho fumanoe hore litokisetso "Mertenil", "Rosart", "Roxera", "Rosukard" le "Rosulip" li bioequivalent le "Crestor".

Sena se bolela hore ntho leha e le efe e hlalositsoeng ea "Rosuvastatin" e na le phello ea phekolo e tšoanang le ea moriana oa pele, e na le palo e lekanang le matla a litla-morao. Le hoja meriana ea Rosuvastatin SZ, Rosuvastatin Kanon, Rosuvastatin Soteks le Akorta ha e kenelle litekong tse joalo. Kaha lipalo-palo tsena ha li tšehetsoe ke lik'hamphani tsa litlhare, boitsebiso bo fumanoang bo na le sepheo 'me bo lumellana le litsi tsa phekolo ea phekolo ea hypercholesterolemia. Leha ho le joalo, liphello ke tsa li-generic tsa linaheng tse ling feela.

Litlhahlobo tsa litsebi mabapi le lihlahisoa tse theko e tlaase "Rosuvastatin"

Mehleng ea morao-rao analogue e tlaase ea "Rosuvastatin" e tlameha ho bontša hore e na le "bioquivalence" ho "Crestor", mme ka mor'a moo e amohela tlhompho ea litsebi. Kantle ho lipatlisiso tsa bioequivalence, litsebi li ka hlokomela feela likarolo tsa kemiso ea kopo. E 'ngoe ea tsona ke ena: ka tšebeliso ea kamehla ea li-analogues tse theko e tlaase tsa "Rosuvastatin" (litokisetso li boletsoeng ka holimo), hangata litla-morao li tšoana le tse hlokometsoeng ka tšebeliso ea lihlahisoa tse tloaelehileng tse kang "Crestor".

Lintho tse fokolang tsa mahlaseli a "plasma" a "rosuvastatin" a hlahang ho sebelisoa ha foromo e tiileng le ho qaptjoa hape, tabeng ena, e nkoa e se ea bohlokoa. Ka lebaka lena, sebopeho se theko e tlaase sa Russia sa "Rosuvastatin" se ka nkela sebaka sa pele sa lithethefatsi "Krestor" le li-generic tsa eona bakeng sa phekolo ea hypercholesterolemia.

Litšobotsi tsa maikutlo a mokuli

Ho ea ka litlhaloso tsa bakuli ba arolelanang maikutlo a bona ka tšebeliso ea lithethefatsi le ngaka e eang, ho ka khoneha ho khetholla liqeto tse ngata tsa tlhaho. Ntlha ea pele, likahlolo tsa bakuli ka boleng ba lithethefatsi li leeme. Ntlha ea bobeli, ka lebaka la phello e sa tloaelehang ea mokuli, ho khomarela kalafo ho fokotseha, le hoja phekolo e hlokahala ho thibela kotsi ea liketsahalo tse boima. Ntlha ea boraro, bakuli ba atisa ho feteletsa bohlokoa ba litla-morao 'me ba hlokomoloha mechine ea li-plasma lipidogram.