Lithethefatsi "Pentas": litaelo bakeng sa ho sebelisoa, analogs le ulasan pelanggan

Ka lethal dose ea meriana e balletsweng ke "Pentas"? Litaelo bakeng sa ho sebelisoa, 'me ulasan pelanggan ea lithethefatsi o ile a hlalosa mona ka tlase. Hape ka eena sehloohong se thepa fana ka boitsebiso bo mabapi le mefuta e meng ea lokolloa ha lithethefatsi le thepa ea eona.

Sebopeho, sebopeho moriana o

Ho na le liforomo tse 'maloa tsa ho lokolloa nkoa meriana. Re hlahisa ba hona joale.

Ho lokisetsa "pentasil" - Tablets (500 mg, ka 100 mg,) bohato ka nako e telele. Ba tšoeu ka tinge grayish, hammoho le likoatipa tse ngata ba leseli sootho, ho nepahetse ho potoloha sebopeho, le Valium, bevel le mengolo e ka mahlakoreng a mabeli.

Karolo ea mafolofolo tsa meriana ena ke mesalazine. Hape le mokhoa oa ba ka sebōpeho sa kopanele tšebeletsong metsoako povidone, ethylcellulose, magnesium stearate, talc, le microcrystalline selulose.

Ka thekiso ya lithethefatsi "Pentas" (matlapa), photo photo photo photo ea eona e fanoa sehloohong se e fane ka dipakete blister tse ka mabokose pampiri.

Ho lokela ho hlokomeloe hore taba eo moriana o ka rekoa ka mokgwa wa suppositories, matlafalitseng-ho lokolloa granules le rectal fanyeha.

moriana Pharmacology

ke pheko bakeng sa "Pentas" ke efe? Litaelo bakeng sa ho sebelisoa e bolela hore moemeli sena ka-ba khahlanong le a hlabang bohato 'me a sebelisa ho tšoara ulcerative colitis le lefu Crohn e.

-Ba khahlanong le a hlabang thepa ya moriana o ile a bontša feela bakeng sa ho sebelisoa sebakeng seo. ketso ena ho bakoa ke tswakana tsa leukotrienes le prostaglandins, hammoho e le thibelo ya mosebetsi lipoxygenase (neutrophil). Ho feta moo, ke sesebelisoa ke kgona ho khina ho secretion ea immunoglobulin ke lymphocytes le ho thibela metsoako degranulation, le phagocytosis tsa neutrophil falla.

mahlahana a haholo-holo gastrointestinal

The moriana o "pentasil" (letlapeng), le ho hlophisoa ha eo e ne e hlahisoa ka holimo, lipontsuoa phatlalatsa mosebetsi antibacterial khahlanong le ba bang ba cocci le Escherichia coli. Hape, ho na le le phello antioxidant ka lebaka la ho matla a ho tlama ntho a sebetsang a ka radicals mahala (oksijene) le ho timetsa bona.

tšebeliso e loketseng ea bukana ena haholo ho fokotsa kotsi ya kula hape ka lefu Crohn, ho akarelletsa le batho ba nang le ileitis (ka nako e telele nako lefu).

Molao-motheo oa tšebetso ea ho mehaho e ya kalafi

Joang lithethefatsi "Pentas"? Litaelo ka kopo e bolela hore phello phekolo ea lithethefatsi ke hang-hang ka mor'a ea lihlooho tsa puisano mesalazine kopana le mucosa mala.

Ka mor'a ho nka molomo Letlapa bolela hang-hang disintegrates ka microgranules eo sebeletsa e le diforomo tse arohaneng le matlafatsa le mafolo-folo ntho ho lokolloa - mesalazine. Sena se fana ka glamour lithethefatsi bakeng sa pakeng tsa 12- ho rectum ka makgabane tsohle ph.

Pharmacokinetics mokgwa

Joang absorption ea lithethefatsi "Pentas"? Litaelo bakeng sa ho sebelisoa ea tlaleha hore microgranules matlapa qhalane 12 fihla duodenum ka metsotso e 60 pele.

Hoo e ka bang 30-50% ea litekanyetso li behoa ananelang tsa moriana ka intestine nyenyane. Le be le Puisano mesalazine le liprotheine lero la mali e 43% le asiti N-acetyl-hlano aminosalicylic - 73-85%.

Mesalazine le derivatives lona se phunyeletse le BBB. thepa Cumulative lithethefatsi li bonahatsoa feela ha u sebelisa tekanyetso e phahameng (ka 1500 mg, ka letsatsi).

Acetylation mesalazine e pepesa ka mucosa mala le sebete. ntho ena e tsoa ho moroto, lebese le mantle.

Bontšang bakeng sa tshebediso ya meriana

Maemong a mang, meriana le ka ho bontša "Pentas" (matlapa)? litsebi Guest re lithethefatsi o etsa hantle ha:

• ulcerative colitis;
• lefu Crohn e.

Ho thibeloa le ho sebelisa lithethefatsi ho

Tlas'a hore na maemo e ka se ke ua sebelisa sesebelisoa sa kang "Pentas"? Litaelo (matlapa le mefuta e meng ea lithethefatsi na le contraindications tšoanang) e re: lithibelo tse latelang:

• hemorrhagic diathesis;
• mafu a mali;
• diabolololo;
• Tshilong ya dijo liso pampitšana;
• fetileng libeke tse 2-5 a bokhachane;
• tlhokeho ya tsoekere-6-phosphate dehydrogenase;
• a le lilemo li tse peli;
• matla renal ho hloleha;
• hypersensitivity ho mahlahana dintho;
• haholo e amanang le sebete insufficiency.

tlhokomelo e khethehileng e lokela ho nkoa e le ea lithethefatsi a sebelisa ho trimester pele tsa boimana, hammoho le sebete 'me liphio hloleha.

Moriana o "Pentas": litaelo tsa tšebeliso

Khetha litekanyetso li behoa foromo ya moriana itšetlehile ka diriswa ea ka sehloohong pathologic thulaganyong, hammoho le bolelele ba diso mala.

Suppositories "pentasil" le ho fanyeha ne a tsamaisoa ka liforomo distal lefu lena (proctosigmoiditis). Ka nako e tšoanang likerese tse tharo o ile a sebelisa ka letsatsi la 500 mg,.

Tsela ea ho laela meriana molomo "Pentas" (matlapa)? Litaelo bakeng sa ho sebelisoa e bolela hore mofuta ona wa ea lithethefatsi buelloa feela diforomo le tloaelehileng la lefu. Bakeng sa thibelo ea relapses ka lefu Crohn e le moriana o sebelisoa ka makhetlo a mane ka letsatsi (1 g, mesalazine). Mabapi le ho thibela khutlela mokhoeng oa UC, tabeng ena, le lithethefatsi e hlophisitsweng makhetlo a mararo ka letsatsi le 500 mg,.

A sa le exacerbation ea 'nete hore lefu le tsa kalafo lokela ho ba teng ka bakeng sa libeke tse 8-12. Ka nako e tšoanang letsatsi le letsatsi ba lokela ho nka 400-800 mg, ea lithethefatsi le (ka makhetlo a mararo letsatsi le letsatsi).

Ka lefu le matla a ka eketsa litekanyetso li behoa ea letsatsi le letsatsi ea g, 3-4

Tablets "pentasil" lokela ho ka go tlhaolega ho nkoa ka ka ho toba ka mor'a lijo, mokelikeli squeezed metsi tloaelehileng.

Liketso tsa ka-le ditlhaka

Maemong a mang, le lithethefatsi potso ke litla ba latelang lehlakoreng:

• stomatitis, tremor ea maoto le matsoho, e omeletseng molomo, molikoalikoane, ho nyekoa ke pelo, tepeletseng maikutlo maikutlong;
• tahlehelo ea takatso ea lijo, ikutloa palpitations, lesokolla, bokhutšoanyane phefumoloho nakong ikoetlisa, ho hlatsa;
• hematuria, letšollo lefu, tachycardia, lefu la sebete, bohloko sefubeng;
• eketseha sebete enzyme, liphetoho khatello ea mali, pancreatitis, polyneuropathy;
• crystalluria, tinnitus, proteinuria (protheine excretion), alafa hlooho ea migraine;
• oliguria, leukopenia, anuria (sieo ha ho ntša metsi), thrombocytopenia, sebopeho nephrotic lefu ;
• hypoprothrombinemia, agranulocytosis, eosinophilia, khaello ea mali.

Ho lokela ho hlokomeloe hore ho ja ya lithethefatsi sena mokuli ka a re: olisgospermiya, alopecia, photosensitivity, bofokoli ka maoto le matsoho, lupus-joaloka lefu, fokotswa tlhahiso ea lachrymal mokelikeli, parotitis.

Overdose ea lithethefatsi

o sebetsana Overdose le mokhoa oa ho sebelisa li eketsehile ho ke boroko, ho nyekoa ke pelo, gastralgia, ho hlatsa le ho fokola ho pholletsa le 'mele. Ho felisa matšoao a tsena hloka ka potlako gastric lavage hammoho le ho khethoa laxatives meriana le posindromnoy phekolo.

ditshebeditsano lithethefatsi

The moriana o "pentasil o" khona ho fokotsa tekanyo ea absorption ea cyanocobalamin. Mesalazine hape eketsa bokgoni ba mahlahana uricosuric (ho akarelletsa le blockers ea secretion tubular).

Hape re lokela ho ela hloko hore le keketseho a sebetsang a lithethefatsi ulzerogennosti glucocorticosteroids fokotsa phello ea rifampicin le kgothaletsa ho toxicity ea methotrexate fana ka e le hantle hypoglycemic ka derivatives sulfonylurea, spironolactone, furosemide le sulfonamides.

lintlha tse hlakileng

Ka tumello ya lethal dose e le ba se nang balekane ba mesalazine e kgothaletswa ho nka hammoho le tse latelang kapa nakong e tlang e haufi haholo. Haeba ho ne ho le sieo ka tekanyetso tse seng kae, o lokela ho hang-hang a bale ngaka ya hao. Ho e thibetsoe ho emisa kalafo ba le bang.

Ka linako tse ling semelo sa mahlahana itlalehang ho bakuli hlokomela moroto letheba le lilense ikopanye le ka bosehla lamunu Hue.

Ka ho phekola mesalazine hloka ea kamehla tlhokomelo ya kalafi okametse mosebetsi oa tsamaiso ea renal tsa mokuli. Hape, ho hlahloba moroto oa mokuli 'me mali a e lokela ho ba kamehla (ho pholletsa le tsela ea phekolo, hammoho le mora phethoa).

Kgonego ya ketsahalo a itšoare e bohloko ka ho bakuli ba fumana lithethefatsi ena e ile ea eketseha ka batho ba "acetylators lieha".

Le ntshetsopele ya lefu a hlobaetsang le tsa ho se mamellane le motho ea mafolofolo motsoako ho lokisetsa "Pentas" hang-hang phethola.

lithethefatsi tšoanang le ulasan pelanggan mosebedisi

Na u se u tseba seo a ka nkoa ho nka sebaka meriana? Ena o lokela ho tsebisa ngaka ea libokeng. Ka puso ea kakaretso, ho analogues oa sesebelisoa se akarelletsa lithethefatsi tse latelang: "Mesakol", "Salozinal" "Salofalk", "Mezavant", "Mesalazin" "Asacol".

Seo batho ba se buang mabapi le sesebelisoa sena, bareki? Ho latela likarabo tsa bona, a re moriana o ke lithethefatsi haholo e atlehang e ka rekoa ka famasi efe kapa efe. Bakuli ba bolela hore mesalazine ke o bonahatsa molemo haholo ka boeona e, eseng feela ka kalafo empa hape le ka ho thibela lefu Crohn le ulcerative colitis.