Lithethefatsi "Mikosist": recensioni, analogues, theko. Lithethefatsi "Mikosist": litaelo tsa tšebeliso

Lithethefatsi "Mikosist" taeo pukwanana e hlalosa e le moemeli antifungal. The a sebetsang a motsoako oa lithethefatsi liketso fluconazole - ka khetha sesitisa tsa sterol tswakana ka lisele fungal. Ho patelang batho tsamaisong batho cytochrome P450 ha bontša mosebetsi androgenic, ho ke ke e atlehang mabapi le likokoana-hloko tsa mycosis.

Pharmacokinetics

Mora molomo kapa intravenous moriana o "Mikosist" (mosebedisi e bontša ena) hantle ka maro a 'mele le lisele. Ka sekhohlela, peritoneal mokelikeli le articular, mathe, lithethefatsi lebese mahloriso a tšoanang le hore fihlellwa ka lero la mali mali. The dikahare tsa fluconazole ka mokelikeli cerebrospinal ka bakuli ba meningitis fungal ke ba etsang liphesente tse mashome a robeli ba mahloriso ka lero la mali, eo le eena, a ke ka ho toba tekanyo e lekanang ya ho lethal dose ya. Ha kopo hang-ea letsatsi le letsatsi ho ea bone-bohlano letsatsi la karolo ea 90 lekholong e fihlellwa equilibrium mahloriso. Ha letsatsi la pele ho nka lethal dose ka feteletseng ea linako tse tloaelehileng tse peli, o ka ba le letsatsi la bobeli ho finyella karolo ea 90 lekholong ea equilibrium bokella. Motso ho ba lekholo ba tlame fluconazole ho liprotheine lero la mali leshome le metso. Ka metabolites mali pheriferale ha ba lemoha. Pharmacokinetics itšetlehile hantle ka liphio, hobane lithethefatsi e excreted haholo-holo o bontša, 'me mabapi le mashome a robeli ba etsang liphesente tse - e sa fetohe. Ka hare ho lihora tse tharo tsa dialysis ea mahloriso ba mafolofolo ntho ka lero la mali le e fokotsehile ka halofo.

bontšang bakeng sa

E kgothaletswa ho sebelisa lithethefatsi "Mikosist" thrush, ho akarelletsa le generalized, disseminated, genital, ha mefuta e meng ea Candida tshwaetso itaolang, candidemia, 'me ka ho ba teng ha lintlha tse esengaka hore ho hlaha ha thrush. Hape ho bontšoa ke tšebeliso ea lithethefatsi bakeng sa batho ba nang le mucosal candidiasis: pharynx; molomo candidiasis ho akarelletsa atrophic, hlahang ho tloha apere meno a maiketsetso; metso. Medicine "Mikosist" taeo pukwanana khothalletsa laolwa ho bakuli ba nang le meningitis cryptococcal, kapa sepsis, cryptococcosis, cryptococcal tshwaetso ya letlalo kapa matšoafo. O ile a boela a sebelisa bakeng sa ho thibela boipheto ea tsela e sa tloaelehang tsena ka bakuli ba AIDS le maemong a mang ba immunodeficiency. Meriana sebediswa ho thibela tšoaetso ea fungal ka batho ba nang le lihlahala tse kotsi, habonolo ka lebaka la mahlaseli a kotsi kapa ka chemotherapy ho hlōla ya data. Hape, lithethefatsi "Mikosist" e sebediswa ea ho phekola ba fungal mafu a tsoaetsanang groin le 'mele, tebileng tloaelehile haholo mycoses, ho akarelletsa le paracoccidioidomycosis, coccidioidomycosis, histoplasmosis ka bakuli ba tsamaiso ea ho tloaelehile' mele.

The litekanyetso li behoa foromo, ambalaji, sebopeho

Tse pedi litekanyetso li behoa mefuta e meng ea moriana o nang le "Mikosist": capsules le tharollo bakeng sa Infusion. Capsules entsoe nang 50, 100 le 150 milligrams ea fluconazole. Kaofela ha bona ke e thata gelatin ka opaque 'mele tse tšoeu,' me li fapana feela lids 'mala: y el capsules nang milligrams 50 ba mafolofolo motsoako o, leseli le' mala o moputsoa cap, 100 milligrams - turquoise, 150 milligrams - putsoa. Dikahare ke phofshoana e tiileng boima kapa o mosoeu (hoo e ka bang e tšoeu) phofo. metsoako kathoko sebetsa magnesium stearate, lactose anhydrous, colloidal silicon e dioxide, talc, thaethaniamo dioxide, starch poone, edible gelatin, Indigo carmine. Capsules nang 50 le 100 mg, ea fluconazole, ba marketed liphutheloana le e 'ngoe, e' meli, machachetsi a mane, likotoana tse supileng e mong le e. Le bao e leng hore na milligrams 150 ba mafolofolo motsoako o - likoto le 'ngoe kapa tse peli.

Infusion tharollo o na le mofuta o mong oa e bonaletsang, colorless kapa habobebe mala mokelikeli. E mong e ne e ena milligrams tse peli ka millitara tsa ntho mafolofolo. Metsoako e mahareng a metsi bakeng sa ente le sodium chloride. Ajoang tharollo ka khalase vials dimililitha lekholo kenngoa ka mabokose a dikhateboto. pakete e mong e na le vial ngoe.

Mokhoa oa ho nka "Mikosist"? litekanyetso li behoa

The lethal dose ho tloaelehileng ho fluconazole ka tshwaetso cryptococcal ke letsatsi la pele la kalafo, 400 mg,, ka matsatsi a latelang - 200-400 milligrams. Ka nako ea phekolo e itšetlehile ka ho tiisa ho ithuta mycological ya bohlokwa ba tsamaiso ea tleleniki, hangata ho se na tse fetang tse tšeletseng - robeli libeke. Ka meningitis cryptococcal sebelisa moriana "Mikosist" litaelo bakeng sa ho sebelisoa khothalletsoang hore leshome - libeke tse leshome le metso e ka mor'a Phello e bile mpe ithuta disampole mokelikeli cerebrospinal. bakuli ba AIDS mora phethoeng tsa kalafo ka lekhetlo la pele e bontšoa bakeng sa thibelo ea boipheto tsa meningitis cryptococcal bakeng sa nako e telele ea baeti ba fihlelang ho le bolela "Mikosist" ka lethal dose ea la ho se ka tlase ho tse makholo a mabeli milligrams ka letsatsi.

Bakuli le candidiasis disseminated, candidemia le tšoaetso ea tse ling tse itaolang Candida, hangata ka letsatsi la pele la ho nka milligrams tse 'nè tsa moriana,' me ka le hlahlamang matsatsi a seng makae - milligrams makholo a mabeli letsatsi le letsatsi. Tabeng ea matla systemic tomoso lethal dose ka eketsehile ho milligrams makholo a robeli ka letsatsi. Kalafo lokela ho tsoela pele ka libeke tse bonyane tse peli ka mor'a ho felisa matšoao a le fumana mali setso negative. Ha candidiasis oropharyngeal, ho akarelletsa le ho bakuli ba sireletsehile maloetseng ana phytoteratology, lithethefatsi litekanyetso li behoa ka letsatsi e mashome a mahlano - lekholo milligrams, ho nka hore e be e le nako ea lilemo tse supileng - matsatsi a metso e mene. Ka atrophic candidosis sephetho ho tswa apere meno a maiketsetso hangata balletsweng noa letsatsi milligrams mashome a mahlano tsa moriana hammoho le sebolaya dikokwana-hloko. Phekolo ea tsoela pele ka libeke tse peli. Bakeng sa mafu a tsoaetsanang a mang Candida (candiduria, esophagitis, letlalo le mucosal candidiasis) lethal dose ea letsatsi le letsatsi ea meriana e mashome a mahlano - lekholo milligrams, phekolo e metso e mene - matsatsi a mashome a mararo.

E le hore ho felisa ka bosaling candidiasis moriana o "Mikosist" taeo pukwanana bontšana amohela singly ka palo ea 150 milligrams. Ho ka ba ho e mene - likhoeli tse leshome le metso e hang ka khoeli ho noa komiki e mong (150 mg,) ho fokotsa maqhubu a ya relapses. Hangata e ba laela hore candidiasis, ho phaella ho ea lithethefatsi "Mikosist" likerese, ho etsa mohlala, "Terzhinan", "Clione-D", "Ginezol". Ho itšetlehile ka tekanyo e kotsi ea tšoaetso fungal, bakeng sa thibelo ea candidiasis letsatsi le letsatsi ae buelletseng lethal dose ya moriana ka fapana ho ea mashome a mahlano ho milligrams makholo a mane.

Tabeng ea mycoses tebileng tloaelehile haholo ka 'na lokela ho nka lithethefatsi ka litekanyetso li behoa ea ba makholo a mabeli - milligrams tse makholo a mane ka letsatsi ka lilemo tse peli. Ka nako ea phekolo e itšetlehile ka motho ka mong le setshwantsho litleleniki tsa: ka coccidioidomycosis, e ka Range ho tloha motso ho likhoeli tse mashome a mabeli a metso e mene, paracoccidioidomycosis - ho tloha likhoeli tse peli ho isa ho leshome le metso e supileng, histoplasmosis - ho tloha ka likhoeli tse tharo ho leshome le metso e supileng.

melao kopo

Intravenous rothele ho lokisetsa lokela ho ho tsamaisoa ka lebelo la ho se fetang mashome a mabeli dimililitha ka motsotso. Ho na le ke ho hlokahale hore fetola lethal dose ea letsatsi le letsatsi ha fetisetsa bakuli ba tloha intravenous ho meriana ka molomo. tharollo A bakeng Infusion ke lumellana le dvadtsatiprotsentnym tsoekere tharollo; ditharollo Hartman le Ringer; tharollo ea carbonate sodium hydrogen, chloride potassium ka tsoekere e, sodium chloride (0,9%). Infusion ka 'na ho phethahatsoa sebelisa lebokosana tlwaelehileng fluconazole bakeng sa tšelo ea, a sebelisa e mong oa ditharollo latelang.

litla-morao

Boholo ba bakuli ba ileng ba lithethefatsi "Mikosist 'ulasan pelanggan ka ho siea e ntle. Lithethefatsi ha e le hantle katleho felisa tsoaetsanang fungal empa ka etsa hore liphello tse bohloko. Ho joalo, ho tloha tsamaiso tshilong ya dijo ke kotsing ea ho nyekeloa ke pelo, flatulence, e sa tloaelehang sebete mosebetsi, mathata le kutloisiso ea tatso, letšollo. Hape, batho ba bang ba bua ka ketsahalo e ea ho tšoaroa ke hlooho, sethoathoa, ho tsekela. Ba bolela hore liketsahalo joalo li itlhahela nakoana ka mor'a hore ho nka lithethefatsi, "Mikosist". Reviews of bakuli ba bang ba le boitsebiso bo mabapi le tsoelo-pele ea phekolo allergy lithethefatsi ka mokgwa wa etymology, lekhopho, angioedema, urticaria. Har'a litla tse ling khoneha lehlakoreng lokela ho hlokomela alopecia, fibrillation ventricular, liphio mosebetsi phytoteratology, hypertriglyceridemia, hypercholesterolemia, le hypokalemia.

Contraindications

Ka mokgwa wa capsules ha baa lokela ho e beuweng meriana ho bana ba ka tlaase likhoeli tse tšeletseng la lilemo (bakeng sa masea lumelloa ho sebelisa lithethefatsi ka sebōpeho sa tharollo bakeng sa Infusion). U se ke ua sebelisa lithethefatsi ena "Mikosist" lactating basali (bakhachane lokela ho abela ka tlhokomelo), hammoho le batho ba nang le nahanela phahameng ho metsoako e kenyelelitsoe ea ho hlophisoa. Le eketseha tlhokeho ya ho sebedisa hlokolosi ho bakuli ba renal / e amanang le sebete insufficiency, ho se mamellane ea acid e acetylsalicylic.

overdose

"Mikosist" tlaleha maemo a ho overdose ea lithethefatsi. Reviews ba batho ba o ile a nka lithethefatsi tekanyetso ka tsela e feteletseng, bontša ho hōla ha letšollo, ho nyekoa ke pelo, ho hlatsa. Maemong a matla, ho na le ponahalo ea sethoathoa, boitšoaro paranoid, lipono. Motho ea nang le matšoao a overdose lokela ho ho nkoa ka sepetlele, moo gastric lavage tla etsoa ho eena, dialysis, qobelloa diuresis, bontshang matshwao phekolo.

"Mikosist" kapa "Fluconazole": e molemo?

Kahoo potso hangata ile a botsa ke bakuli. Ha e le hantle, ho sebelisa lithethefatsi ka bobeli ba e tšoanang, re ka bolela hore ba ile ba ba le tsoanang. Phapang feela ke hore lithethefatsi "Mikosist" etsa hore Sehungary khampani meriana "Gedeon Richter", ha a ntse a "Fluconazole" - ho ba lokisetsa ho ea fana ka tlhahiso ea malapeng. Ya e le hantle, sena e na le tšusumetso e ka ho toba le litšenyehelo tsa meriana. Khetha seo ho reka - "Mikosist" kapa "Fluconazole" - ngata khetha ho ea lithethefatsi, e leng theko e tlaase. Ka sebele, phapang bohlokoa ka theko. Ho joalo, bakeng sa ambalaji tsa "Mikosista" (mong komiki nang milligrams 150 tsa fluconazole) o lokela ho lefa e leng karolelano ea 295 li-ruble, ha sephutheloana tšoanang "Fluconazole" theko li-ruble 8-20 feela. Theko karolelano ea ya 100 di ml botlolo ea tharollo bakeng sa Infusion "Mikosist" ke 311 li-ruble.

Ha e le thepa diokobatsi ya lithethefatsi tse peli, ba ile ba ba hoo e batlang e le tsoanang, phapang e ka bonoa ntle le hore tekanyo ea absorption: ho latela ya data le teng, ea mahloriso lebetsoeng le 'meleng "Fluconazole" e finyelloa ka mor'a lihora tse 1-2 ka mor'a kopo,' me "Mikosista" - 0.5 -1,5 lihora. Leha ho le joalo, ha bakuli bohle ba arabela meriana le ba babeli ka tsela e tsoanang. Ba bang ha ba bone phapang pakeng tsa bona, ha a ntse a ea bobeli lumela hore boleng bo itšetlehile ka theko, e bolelang hore ho na le ea lithethefatsi ke e theko e boima ho feta, molemo. Hangata u ka fumana ulasan pelanggan oo basali ba bolela hore ka mor'a ho nka "Fluconazole" thrush a khutla, empa "Mikosist" lumelloa ho tlosa e ka ho feletseng. Leha ho le joalo, le ho khetha ke ea hao.

analogs

Ho phaella tabeng ea ho "Fluconazole", ho na le meriana e meng e ka nka sebaka sa lithethefatsi "Mikosist". Analogs moriana o le e le motho ea mafolofolo motsoako o le ntho e tšoanang, ba hantle emeloa. Ka mokgwa wa capsules bakeng sa kalafo ya tomoso le tšoaetso ea tse ling tse fungal, u ka sebelisa "Diflucan" lithethefatsi "Flucostat", "mikomaks" le ba bang. E mokgwa e atlehang ke "Mikoflyukan" (matlapa). "Mikosist" ho tloha analogs tsohle tsena fapaneng ke litsupa kang bioavailability, halofo ea bophelo ba, e leng tekanyo ea absorption.

ditshebeditsano lithethefatsi

Hoa hlokahala ho ka hloko hlokomela prothrombin nako bakuli fumana fluconazole hammoho le sa tobang anticoagulants coumarin sehlopha, hobane ho na le kotsi ea ho eketsa VWP. Ha concomitantly le sulfonylureas lithethefatsi "Mikosist" e ka lelefatsa le halofo ea bophelo ba bona, kahoo u lokela ho nahana ka monyetla oa ho hypoglycemia. Tabeng ea fluconazole le ho abelana phenytoin ka ea bongaka bohlokoa tekanyo ea keketseho ea mahloriso ea ho qetela, ka lebaka leo, ha ho hlokahala ho kopantswe fumana lethal dose lokela ho tsa fokotswa. Hammoho kenoa ho bolela "Mikosist" le rifampicin tla tšoauoa fokotseha ka mahloriso tsa fluconazole Ka hona lethal dose "Mikosista" ho hlokahala hore ho eketsa. Ho sebelisoa ho kopantswe ea sehlahisoa azole le moriana o ka hammoho le terenadinom contraindicated, e ka ba le matla, e behang bophelo kotsing arrhythmia. Haeba u noa meriana "Mikosist" hammoho cisapride, ka bontša liphetoho tse sa rateheng ka lehlakoreng la pelo, ho akarelletsa le tachycardia ventricular. Le ho sebelisa tsoa hong ea fluconazole le theophylline fokotswa ka karolelano sekhahla rengwa tloha lero la mali tsa mali ho qetela, 'me ka hona ho eketsa monyetla oa tsoelo-pele ea liphello tsa eona tse chefo le overdose.

lemosa

Lokela ho tsoela pele kalafo le "Mikosist" ho fihlela ea tleleniki le hematological kokobetse. Pele ho nako discontinuation ea phekolo e tletse lintho tse ngata relapses. Joalokaha ho se ho boletsoe, bakuli ba insufficiency renal lokela ho sebelisa lithethefatsi le hlokolosi palo e kahodimodimo, hobane e excreted haholo-holo ka ho a liphio le. Litekanyetso li behoa ka nako kalafo nako e telele lokela ho etsoa, nahane CC. Ka linako tse ling fluconazole akarelletsa litla nang le chefo e ka sebete ho, kahoo, ho ke ho hlokahala hore ho hlokomela ea ka tšebetso ea 'mele ona. Holim 'a ba bonoa matšoao diso lokela thibela meriana.

Bakuli ba ka semelo sa "Mikosist" ho bolela ho bile ka seoelo sightings exfoliative cutaneous liphetoho, tse kang tse chefo epidermal necrolysis le lefu Stevens-Johnson. Bakuli ba neoplasms bolaeang le AIDS ke le kotsing ea ho ho hlaha ha liphetoho tse matla letlalo ha u sebelisa litokisetso nang fluconazole. Haeba nakong ea kalafo ya fungal tshwaetso ka ntle feela le lekhopho le hlaha, le lithethefatsi o batla ho hlakola. Haeba u e-ba lekhopho ka batho ba nang le tšoaetso ea itaolang kapa systemic fungal ngaka lokela ho matlafatsa tlhokomelo le ho phumulwa ea lithethefatsi ketsahalo eo e tla hlahisa etymology multiforme, kapa diso bullous. Nakong ea kalafo, litlhare "Mikosist" (ulasan pelanggan netefatsa e) ho ka etsa hore ho tsekela, kahoo bakuli lokela ho ba hlokolosi haholo-holo ha ho sebetsa le mokhoa le taolo ya likoloi.