Lithethefatsi "Merkazolil" taeo

Lithethefatsi tla ka foromo Letlapa. Diokobatsi ketso e thehiloeng
antithyroid thepa ea boleng bo mafolofolo nakong - methimazole (5 mg, ka 1 Letlapa). Medicine "Merkazolil", le lekodisisa lingaka netefatse ho thibela ho potlakisang tsebetso ea lik'hemik'hale peroxidase, e ke ke ha khoneha ntle itšoara joang iodization hormone thyroid ka thyroid tsoelesa e. Phello ke likhathatso tsa sebopeho kalafo thyroxine le triiodothyronine.

Methimazole e hantle ananelang pampitšaneng gastrointestinal. The halofo bophelo ke dihora tse 6. E metabolized 'meleng, e ka ho feletseng felisoa ke liphio.

Lithethefatsi "Merkazolil" taeo

moriana e hlophisitsweng:

• ka tireotoksicheskom leqeba ;
• ka diffuse goiter chefo;
• tlas'a tsoakiloeng chefo goiter ea ho phekola e rarahaneng le mahlahana thyroid li-hormone kapa ntšang mahlaseli a kotsi a iodine phekolo.

Medicine "Merkazolil": litaelo tsa tšebeliso

Litekanyetso li behoa ngaka khethang le batho ka bomong ho itšetlehile ka boemo ba mokuli. Ka tloaelo ho laetsoeng, mg 20 mg, ho 40 tsa methimazole letsatsi le letsatsi. Recommended letsatsi lethal dose arotsoe ka tekanyetso 2-4. Tlwaelegileng a ea thyroid mosebetsi a hlokomela mora kalafo merkazolilom hlolang ka nako ho tloha 3-e neng ho libeke tse 8. Ka mor'a hore mokuli a ikutloe liphello tse ntle o ile a fumana e isoa tokiso Thiamazolum phekolo ka tekanyetso ho tloha 2,5 mg, ho 10 mg, ka ho ya ka letsatsi.

Phekolo letsatsi lethal dose bakeng sa bana ba tloha micrograms 1 ho ea ho 300 ka lik'hilograma ho 500 mg, ka ho ya ka tse 1 kg. Tšehetsang letsatsi lethal dose bakeng sa bana e tloha micrograms 1 ho tse 200 ka lik'hilograma ho 300 mg, ka ho ya ka tse 1 kg. Maintenance lethal dose ya methimazole laolwa e mong-nako, hoseng ka mor'a lijo tsa hoseng.

Le bolela "Merkazolil": litla-morao

Nakong ea liteko tse matla tsa tleleniki ea lithethefatsi ba ne ba hlokometse liphetoho seoelo alejiki ka mokgwa wa le lekhopho kapa feberu; bakuli motho tlalehile matšoao a volchanochnopodobnogo lefu.

Ho tlola ea tsamaiso hematopoietic ke ka seoelo leukopenia, agranulocytosis; matšoao a lymphadenopathy generalized ne a hlokomela bakuli le 'ngoe.

Irregularities tsamaisong ea tshilong ya dijo tse sa tloaelehang phetoho ka tatso; bakuli motho e ile lemoha lefu sebete, mo khothalletse ho hlatsa le ho nyekoa ke pelo.

Meferefere tsamaisong ea methapo ea kutlo e bososolami feela Maemong a seng makae, ba bonahatsoa neuritis le polyneuritis, hlooho e opang.

Disruptions tsamaiso ea endocrine o ile a bontša hyperplasia ya thyroid tsoelesa e.

Lithethefatsi "Merkazolil" taeo: contraindications

Ho ke ke ha khoneha ho hlalosa lithethefatsi:

• ka leukopenia haholo kapa granulocytopenia;
• hypersensitivity ho methimazole;
• nakong ea bokhachane;
• diabolololo.

Lehlakoreng liphello tsa moriana "Merkazolil" bakhachane ba amanang le matla a ho tšela mokoallo placental. Ka hona, ho sebelisa methimazole ka mor'a hore ke trimester tletse lintho tse ngata ho hōla ha hypothyroidism ka lesea la.

Le litla-morao tsa lithethefatsi "Merkazolil" letsoele-ho fepa bo-'mè ke ka lebaka la ho matla a ho phunyeletse ka lebese.

Medicine "Merkazolil" Taeo: khethehileng litaelo

kalafo Thiamazolum akarelletsa ho hlokahala hore a kamehla hlokomela mali setshwantsho.

Kalafo ea kgolo Strum thyroid rarahaneng constriction tsa trachea lokela ho tsamaisoa ka bokhutšoanyane. kalafo ka nako e telele se ka mo lakalisa kgolo ya Struma.

Ba bonnete ba hore a phethe ka a buisane le mamello pele kalafo merkazolilom ho hlalosa hore ho hlokahala hore a ee ngakeng ka matšoao pele la liphetoho tse khalemelang tse bonakong ba mmuso. feberu ena, metso, ho ruruha ha lera la mucous ea molomo, ponahalo ea lethopa le - le matšoao a tloaelehileng agranulocytosis.

Ha ho buuoa ho khethoa ha tlang Merkazolil hlakotsoe libeke tse 1-2. Lokisetsa strumectomy etsoa lithethefatsi a iodine litareng e-nang le.

Ho bohlokoa ho hopola hore ha ba na la a iodine litareng e 'meleng oa mokuli eketsa phello ea methimazole, le a iodine litareng e feteletseng lowers liphello tsa methimazole.