Likerese "Flexen": litaelo, litlhaloso, litheko, li-analogies

Likerese "Flexen" e bua ka sehlopha sa meriana ea NSAIDs (lithethefatsi tse seng tsa steroidal tse khahlanong le ho ruruha ). Ba na le khahlanong le ho ruruha, antipyretic, analgesic le anti-aggregation liphello. Meriana e teng hona joale e thibela tšebetso ea li-enzyme (cyclooxygenases 1 le 2) le ho sebelisoa ha prostaglandins. Ts'ebetso ena e thibela ho thehoa ha li -mediator le ho thibela ponahalo ea leukotriene.

Melese ea "Flexan" e bontša mokhoa oa ho loantša bradykinin, ho tsitsisa likokoana-hloko tsa lysosomal, e leng ho baka ho thibela mosebetsi oa neutrophil ho bakuli ba fumanoeng ba e-na le ramatiki ea lefu la masapo. Tlosa ho bokelloa ha li-platelet. Tšusumetso e hlahisang maikutlo e bakoa ke mekhoa ea bobeli le bohareng. Lingaka tse ngata li fana ka "Flexen" (likerese) bakeng sa phomolo ea bohloko le phekolo ea ramatiki. Theko ea lithethefatsi eu lumella ho e reka likarolong tse sa tšoaneng tsa bakuli. Bopaki ba lithethefatsi bo tiisa hore e sebetsa hantle ebile e sireletsehile bakeng sa bophelo bo botle, ha ho ntse ho etsoa litlhahiso tse nepahetseng.

Litaelo tsa tšebeliso ea lithethefatsi li bonolo haholo, 'me litlhaloso li tiisa hore ho bonahala eka ke phekolo ea meriana. Sebopeho sa meriana ke eng? E na le thepa efe? Na ho na le litla-morao tse kotsi? Bakuli ba bangata ba batla likarabo tsa lipotso tsena.

Tlhahlobo ea Lik'hemik'hale ea Meriana

Tokisetso e kenyeletsa mokhoa o rarahaneng oa lisebelisoa tsa bioactive le tse thusang:

• Ketoprofen (motheo oa bioactive methapo);
• Serena;
• Oli ea meroho e nang le oli;
• Silicon dioxide colloid;
• Ethylparahydroxybenzoate sodium;
• Sorbitol;
• Gelatin;
• Oli ea meroho;
• Glycerol;
• Soy lecithin;
• Titanium dioxide;
• Propyl parahydroxybenzoate.

"Flexen", likerese: analogues

Mokhoa oa phekolo ea lingaka, lingaka li sebelisa ka matla litšoantšo tsa meriana e ka holimo:

• "Artrozilen."
• Ketonal Duo.
• Artrum.
• «Bystrumgel».
• "Tšepo".
• Bystrumcaps.
• Ketonal.
• "Orewvel."
• "Fibrofit."
• "Flamax".
• Profenid.
• Ketonal uno.

Melemo

Melemo e ka sehloohong ea meriana e kenyelletsa lintlha tse latelang:

• Tšusumetso e kholo ea phekolo;
• Phaello e phahameng ea lithethefatsi ha e bapisoa le eona e tšoanang.

Litlhahiso tsa meriana

Mathata a mabe a Flexan a kenyeletsa litekanyetso tse latelang:

• Theko e phahameng ea meriana ha e bapisoa le li-analogues;
• Ha ho mokhoa o mong le o mong oa nako e telele (oa nako e telele) oa tokollo o fumanehang.

Pharmacokinetics

Ho koala lihlahisoa tse kotsi tsa moriana o nang le liprotheine tsa mali tsa mali ke karolo ea 99 lekholong. Likerese "Flexen" li tšoauoa ka ho ba le bioavailability e phahameng (ho feta 90%). Matšoao a phekolo ea Flexan maling a lula lihora tse 6. Ntho e khōlō ea ho arohana ha metsoako ea lithethefatsi e hlaha ho hepatocytes ka glucoridation. Nako ea bophelo e ka ba lihora tse peli. Sethethefatsi sena ha se hloekisoe, haholo-holo ke liphio le ka maleng.

"Flexen" (likerese): litaelo tsa tšebeliso, theko

Lithethefatsi tse ka holimo li bontša mokhoa o moholo oa phekolo ea meriana. Tloaelong ea bongaka, ha ho phekoloa lefu la bohloko le liketso tsa ho ruruha tsa liphatsa tse fapa-fapaneng, likerese tsa "Flexen" li atisa ho behoa. Tšebeliso ea lithethefatsi e khothalletsoa bakeng sa ho kula ho latelang:

• Migraine;
• Matšoao a lefu la kelello;
• Tenosynovitis;
• Colic Renal;
• Gouty ramatiki;
• Bursitis;
• Dorsalgia;
• Myalgia;
• Ramatiki ea ramatiki;
• Otitis media;
• Osteoarthrosis ea libaka tse sa tšoaneng;
• Rheumatic polymyalgia;
• Bohloko ba mesifa;
• Ischialgia;
• Phlebitis;
• Ankylosing spondylitis;
• Neuralgia;
• Thrombophlebitis;
• Radiculitis;
• Adnexitis;
• Phekolo ea mafu ka har'a plexus ea lumbosacral;
• Ischialgia;
• Algodismenology;
• Matšoao a lefuoang ka mor'a lefuba le a senyehileng;
• Lymphangitis;
• Matšoao a bohloko ka ho kula ha tlhaho.

Ho reka sethethefatsi "Flexen", eo theko ea eona e fapaneng ka li-ruble 200-300, e nang le lengolo la ngaka le fumanehang pharmacy leha e le efe. Hape ke habohlokoa hore re hlokomele hore hangata likerese tsa "Flexen" tsa mafu a li-gynecology li sebelisoa, li laeloa bakeng sa li-cysts tsa mahe. Ho ea ka bakuli ba bangata, meriana e sebetsa ka katleho. Lingaka tse ngata li bolela hore ka mor'a ho phekoloa ka "Flexen" ka matsatsi a 10 le ka mor'a ho noa meriana e meng ea cyst disappears.

Litlhōlisano

Haeba u etsa qeto ea ho sebelisa likerese tsa Flexen, litaelo tsa tšebeliso e bontša hore meriana ena ha ea lokela ho sebelisoa maemong a latelang:

• Ho tšeloa mali ka pampiri ea matšoao;
• Ho se sebetse ho matla ha sebete le liphio;
• Nako ea ho qobana le ho ima;
• Hypersensitivity ho lithethefatsi tse seng tsa steroidal tse khahlanong le ho ruruha;
• Li-Hemorrhoids;
• "Aspirin" "asthma";
• Mathata a ho tsoala ;
• Proctitis;
• Ho lilemo tse ka bang 15;
• Ho se sebetse ha hematopoiesis system (leukopenia, hemocoagulation disorders, thrombocytopenia, hemophilia);
• Maloetse a tšoaetso ea lijo tsa mokokotlo karolong ea ho fokotsa matla.

Litaelo tse khethehileng

Koetliso ea "Flexen" (likerese) e bontša ho ba le tlhokomelo e khethehileng ho bakuli ba nang le ho se sebetse ha liphio, sebete, tšoaetso ea lijo, ho ba le joala hampe, ho ruruha, ho ruruha ha metsi, ho tsuba, ho ruruha ha mali, ho kula ha mali, Sepsis, lefu la ts'oaetso la lefu la tsoekere, mafu a lefu la pelo le batho ba hōlileng. Nakong ea phekolo, meriana ena e hloka tlhokomelo e hlophisehileng ea liphio le sebete. Haeba "likerese tsa" Flexen "li laeloa hammoho le li-anticoagulants (heparin), kotsi ea ho tsoa mali e eketseha. Koetliso e telele ea phekolo e ka etsahala feela sepetlele. Nakong ea phekolo u se ke ua noa joala.

Lehlakoreng le leng

Na u khethiloe "Flexen" (likerese)? Litaelo tsa tšebeliso ha li thibele tsoelo-pele ea litla-morao. Tsena ke:

• Ho tšoaroa ke hlooho e bohloko;
• Nausea;
• Ho sithabela;
• Ho na le botsoa;
• Ho otla;
• Ho fokotsa takatso ea lijo;
• Ho robala;
• Likokoana-hloko tsa mali;
• Asthenia;
• Ho otsela;
• Conjunctivitis;
• Xerophthalmia;
• Ho tšoha;
• Ho tlosoa ha metsi;
• Lerata litsebeng;
• Ho lebala;
• Pono e fosahetseng;
• Hepatitis;
• Tahlehelo ea kutlo;
• Vertigo;
• Phekolo ea meriana;
• Gastralgia;
• Tachycardia;
• Nako e nepahetseng ea dysuria;
• Hyperemia;
• Eczema;
• Cystitis;
• Lefu la Nephrotic;
• Urethritis;
• Photodermatitis;
• Ho ruruha ha lesira;
• Hematuria;
• Erythema e feteletseng;
• Ho se sebetse ha Renal;
• Matšoao a maholo ;
• Ho hloekisa letlalo;
• Ho fokola ha letlalo;
• Mosebetsi o eketsehileng oa li-aminotransferases (alanine le aspartate aminotransferase) ka seramu ea mali;
• Phefumoloho e khutšoanyane;
• Rhinitis;
• Li-noblebleeds;
• Bronchospasm;
• Anaphylactic shock.

Tšebeliso ea suppositories e ka boela ea baka letšollo, maikutlo a tukang le tenesmus.

Matšoao ha ho feta tekano ea lithethefatsi

Likhase "Flexen" li reretsoe ho sebelisoa ka mahlakoreng - 1 suppository (100 mg) 1-2 ka linako tse ling ka letsatsi. Maqhubu a letsatsi le letsatsi a amohelehang a ketoprofen ke 300 mg. Ha ho feteletsoa ha lithethefatsi, litšoao tse latelang li hlokomeloa:

• Ho se sebetse ha sebete le liphio;
• Ho otsela;
• Nausea;
• Ho tšela mali;
• Bohloko bo matla sebakeng sa epigastric;
• Ho otla.

Haeba lipontšo tse ka holimo li fumanoa, phekolo ea matšoao e behiloe. Li-antidote tse tobileng ha li eo. Adsorbents li sebelisoa mashala, Masabe, Medetopek kapa Neointestopan. Hemodialysis, diuresis e qobelloang - mekhoa e sa sebetseng ea phekolo. Fana ka lithethefatsi tse fokolang tse fokolisang matšoao a kankere ea lijo. Haeba ho hlokahala, glucocorticoids e ka sebelisoa. Ka ho hlōleha ha lesoba, hemodialysis e etsoa. Ha ho thoe "Diazepam" kapa meriana e meng ea benzodiazepane antiticonvulsant; Ka hypotension e matla, limela tsa plasma li hlahisoa (Reopoliglyukin, Polyglyukin, Enterodez, Polidez, Gemodez). Mokuli o hloka tlhokomelo ea kamehla ka matsatsi a 'maloa, kaha ho na le kotsi ea pontšo ea morao-rao ea masapo a mang a meriana (mali, mali a phofo).

Ho sebelisana le meriana e meng

E matlafatsa phello ea li-anticoagulants, fibrinolytics, ethanol, li-antigregregants, ho fokotsa phello ea li-vasodilator, pono ea spironolactone, katleho ea meriana ea meriana, lithethefatsi tsa hypotensive le diuretics. Meriana e ka holimo ha e lumellane le "Tramadol". Tšebeliso e kopanetsoeng ea Flexan le lithethefatsi tse ling tse sa steroidal tse khahlanong le ho ruruha, joala ethyl, glucocorticosteroids, corticotropin e etsa hore ho be le liso tsa lisosa le ntshetsopele ea mali a tsoang mali. Li-Antacids li fokotsa katleho ea meriana. Matsatsi a mabeli pele ho tlhahlobo ea li-17-ketosteroid, sethethefatsi se hlakotsoe.

"Flexen" e eketsa phello ea hypoglycemic ea insulin, hammoho le lithethefatsi tsa molomo oa hypoglycemic. Meriana e nang le myelotoxia e eketsa ponahalo ea hematotoxicity ea lithethefatsi. Ho hlahisa likokoana-hloko tsa microsomal sebeteng ("Phenylbutazone", ethanol, tricyclic e thibelang ho imeloa kelellong, "Phenytoin", "Rifampicin", barbiturates) ho etsa hore ho be le metabolite e sebetsang hantle ea hydroxylated. Ho sebelisoa hang-hang ha Flexan le sodium valproate ho baka tšenyo ea platelet aggregation.

Litlhaloso mabapi le lithethefatsi

Bakuli ba bangata ba thahasella potso ea hore na "likerese" tsa Flexen ke eng. Litaelo tsa tšebeliso, litšenyehelo tsa lithethefatsi, lits'oants'o le li-contraindications ke, ha e le hantle, lintlha tse kholo. Leha ho le joalo, ho bohlokoa ho tloaelana le maikutlo a litsebi le bakuli tabeng ena. Bongata ba lingaka ba lumela hore moriana o motle ka ho fetisisa oa li-analgesic le oa ho hlekefetsa ke Flexen (likerese). Likarabo tsa bakuli maemong a mangata (ho tloha ho 80 ho isa ho 90%) li ntle, tse bakoang ke katleho e phahameng ea meriana, ho imoloha ka botšepehi ho bohloko bo botle ba li-etiologia le libaka tsa sebakeng seo, phello e tšoarellang, le boiketlo ba tšebeliso. Phello e ntle e ka hlokomeloa ho tloha matsatsing a pele a ho kenngoa. Litlhahlobo tse fosahetseng tsa lithethefatsi li amahanngoa haholo le ho hlaha ha litla-morao le litšenyehelo tsa eona, empa mechine e joalo ea lithethefatsi ha e khone ho koala bokhoni ba eona bo phahameng.

Methati ea ho tloha ho li-pharmacy

Lithethefatsi ka mofuta oa suppositories le capsules li lokolloa ka tieo ho ea ka ngaka ea ngaka. Sethethefatsi sa mofuta oa gel se ka fanoa ntle le lengolo la ngaka.

Maemo a polokelo

Tlohela bana hore ba se ke ba fihla mocheso o ka tlase ho 25-30 ° C. Puso ea mocheso e boletsoeng e sebetsa ho mefuta eohle ea ho lokolloa. Bophelo ba lesela bo bontšoa ka har'a sephutheloana. Sethethefatsi ha sea lokela ho nkoa ka mor'a letsatsi la ho qetela!