HCG le mesebetsi ea bona

Hormone tse raznostrukturnyh manyolo dintho khona ho amang ea ka tšebetso ea ho phelang batho. hormone Gonadotropic ama mosebetsi ea tsamaiso ea ho hlahisa bana. Di tsa maiketsetso ka anterior pituitary tšoelesa me ho tloha moo ba secreted ka mali.

The-hormone tsa pituitary anterior

The pituitary tšoelesa e arotsoe likarolo tse peli tse: pele le ka morao. Ka ho toba ka li-hormone pele tsa maiketsetso 'me secreted ka maling. The kamorao lobe ea pituitary tšoelesa, ba tsoa hypothalamus le secreted ka mali feela tlas'a maemo a itseng.

Gonadotropic pituitary hormone susumelletsa ho litsoelesa ho kopanela liphate. Tsena li akarelletsa:

• FSH - follicle-Stimulating Hormone. E khothalletsa batho oogenesis le spermatogenesis. Ke rarahaneng protheine (glycoprotein) e entsoe ka-amino acid kopanngoa le lik'habohaedreite.
• LH - luteinizing hormone ea. E khothalletsa batho ho lokolloa ha lehe ho tloha ovary ho ama secretion hormone ho kopanela liphate (estrogen bananeng, progesterone) tseo e leng banna bakang secretion ea androgens. Ka tjhelete e ya li-hormone e fapana nakong potoloho e mong matsatsing, ho na le tekanyo e lekanang le synchronous secretion ea e itseng eo di ea FSH le LH.

hormona hlahisoeng ha e etsoa gonadotropah (basophilic lisele tse) adenohypophysis. Ba etsa ho fihlela ka 15% ea lisele tsohle tsa lobe anterior.

Boimana hormona - HCG

Haeba manyolo le implantation tsa ovum ka uterine leboteng 'meleng oa mosali o qala ho hlahisa hormone e itseng pituitary gonadotropic hlahiswa chorionic gonadotropin.

Mosebetsi-hormone e ho boloka polokelo luteum tsa mosebetsi (kgetho ya estrogen bananeng le progesterone) ho le nonofo ya mmele e feletseng ea placenta. E fana ka phahameng luteinizing e le hantle 'mele, e leng haholo-holo e leta FSH le LH.

makgetheng mehaho hormone

Mosebetsi likokoana-hloko tsa li-hormone le e fana ka sebopeho sa buka e ikhethang e kenyeletsang subunits tse peli. Ntlha ea pele, a-yuniti e nyane, o na sebopeho hoo e ka bang le tsoanang ka gonadotropins tsohle, ha a ntse a e b-yuniti e nyane e fana ka kgahlamelo ya maqhubu a ikhethang oa ho li-hormone le.

Le batho ka bomong, subunits tsena u se ke ua beha tšusumetso e leha e le efe ka phelang, empa ha ba amana, ha feela mosebetsi oa tsona likokoana-hloko le tšusumetso ka dithulaganyo oa bohlokoa oa e phelang, ka ho khetheha ea tsamaiso ea ho hlahisa bana. Kahoo, li-hormone gonadotropic na le tshusumetso bohlokoa, e seng feela ka boemong ba ho kopanela liphate, empa hape le e hlophisitsweng, le endocrine le molao oa tsamaiso ea ho leka-lekana hormonal.

Ka li-hormone ama 'mele

Ho tloha mehleng ea khale, bo-rasaense ba leka ho ithuta mosebetsi likokoana-hloko tsa li-hormone e le phello ea bona ka 'mele oa motho. Gonadotropic hormone na le tšusumetso e matla ka le thulaganyo ya phelang batho. Ka lebaka leo, thuto ea mochine oa bona oa ketso e potso ea bohlokoa haholo le e thahasellisang. Ka khanna ho etsa lipatlisiso le li-hormone ngotsweng ho ile ha fumanoa hore lisele tsa khona ho hlokomela li-hormone tse itseng 'me u fase feela lisele tse itseng.

Tshebetso ya ho tlama ho sele e etsoa ke ho ba le lera kapa liseleng tsa ka hare le protheine molek'hule - receptor. Intracellular baeti ba fihlelang ho amana le li-hormone steroid, ha ba ntse ba le tšekamelo ea ho phunyeletse ka lisele le tšusumetso e ka mosebetsi oa hae. Lera baeti ba fihlelang ho bath ea li-hormone le protheine e tlame ho barbotage lera seleng.

Tlama tsa protheine hormona receptor khothalletsa batho sebopeho sa rarahaneng ka. sethaleng sena se hloka sebaka se se nang ho kenya letsoho enzyme, 'me ke reversible. hormone Steroid kena ka seleng, tlame ho receptor ena. Ka mor'a phetoho thehoa rarahaneng kena seleng khubu le khothalletsa batho sebopeho sa e RNA itseng ka cytoplasm le eo tswakana enzymatic ya likaroloana baka phello ea li-hormone e ka seleng.

Gonadotropic hormone: mesebetsi le litla ka le thulaganyo tsamaiso e khopo ho ikatisa

FSH mosebetsi fihla phahameng ka ho fetisisa ba batsehali. Ho di hlohleletsago kgolo ya lisele follicular tse tlas'a tšusumetso ea GSIK fetoha bubble le butsoe pele sethaleng ovulation.

Tlas'a tšusumetso ea ho eketseha ha boima ba SFS mae a bomme le testes. Leha ho le joalo, esita le ha ho qaloa ho a maiketsetso a ka li-hormone maiketsetso ke ke ha khoneha ho etsa hore tsoelo-pele ea dinama tse nyenyane tse interstitial, e ama secretion ea androgens ea tlhaho lekwalata.

GSIK le boikarabelo ba ho ovulation le sebopeho sa popelo polokelo luteum. Hape ka kopanelo le follicle hlasimollang-hormone e ama secretion ea estrogen bananeng. Tlas'a tšusumetso ea hormone hore di hlohleletsago lisele interstitial, ho na le ke kgolo ya makala le boikarabelo ba ho le litšobotsi tse mahareng ho kopanela liphate.

Phello likokoana-hloko tsa LTG

LTG ke tsoana haholo le kgolo ya li-hormone. Mora liteko laboratori ea senola hore ba ka molek'hule e tšoanang, kahoo motho e ke ke kgethile ka bomong, e mong le e-hormone tsena. Mesebetsi LTG kenyeletsa secretion lebese le progesterone. Ho bohlokwa ho ela hloko hore dithulaganyo tsena li bakoa ke ho sebelisana ea palo e khōlō ea li-hormone, ho tloha kgahlamelo ya maqhubu a ea 'mele feela LTG makgetheng tsena ha li hlahe.

Ho joalo, bakeng sa kabo ya lebese hloka lihomone tse latelang:

• FSH le GSIK - etsa hore secretion ea estrogen bananeng mae a bomme ka;
• tlas'a tšusumetso ea ho hōla-hormone le estrogen bananeng ke kgolo ya ducts lebese;
• LTG etsa hore secretion ea progesterone ka polokelo luteum;
• Progesterone di hlohleletsago ntshetsopeleng e feletseng ea tšoelesa mammary ka boemo alveolar-lobed.

hormone Gonadotropic hloka sebelisana kamehla ho tiisa hore mosebetsi e feletseng ea 'mele' me tsamaiso ea bohle ba eona. Ke ka lebaka leo ba le tšusumetso e fapaneng tsa e mong le e ba bona ba (tabeng ea tsamaiso ea li-hormone tsa maiketsetso) ha e etsa hore liphetoho lebeletsoe.

hypothalamic hormona

The hypothalamus lokolloang gonadotropin lokolloa ka mali-li-hormone. E na le sebopeho polypeptide le ama secretion hormone pituitary. Ho ea bohōleng bo itseng e ama luteinizing hormone, le follicle ka nako eo. GnRH hlahisoang ka dikgao ya ho hlaka hlalosoa nako, basali, ba ile ba Range ho tloha metsotso e 15 ho 45 (ho itšetlehile ka potoloho e), 'me e leng banna hormone secreted ke mong le e mong metsotso e 90.

Ka maiketsetso a maiketsetso a ka li-hormone tsamaisoa ke dropper hataketse mosebetsi secretion ea li-hormone, e leng ho ba ka lekgutshwanyane matlafatsa secretion, 'me joale - ka cessation feletseng tsa tlhahiso ea gonadotropins ke pituitary anterior.

GnRH pepesehela thulaganyou e ka phelang

GnRH tlhotlheletso fana anterior pituitary lobe, eo lisele tse (gonadotropins) na GnRH receptor itseng bakeng sa secretion ea FSH le LH-hormone, e leng, le eena, a ama ho sebetsa ha gonads ena.

PG di hlohleletsago le nonofo ya mmele ea peō ea botona le lehe le ka liseleng, LH ama secretion hormone ho kopanela liphate (estrogen bananeng, progesterone, testosterone). Tlas'a tšusumetso ea ho kopanela liphate-hormone lisele tse ea tsamaiso ea ho ikatisa butsoe le itokiselitse ho peō.

Ka phallo feteletseng e potlakileng ea dithulaganyo tsa spermatogenesis le oogenesis abelwa inhibin susumetsa hormone gonadotropic tsa anterior pituitary tšoelesa o khothalletsang khoehlisa dithulaganyo le nonofo ya mmele ea diretswe go dira gametes o nka bohato ka follicle Stimulating Hormone.

Hobaneng sebelisa litokisetso gonadotropic

Ka ho eketsehileng ho tloaelehile ya kalafi ka go ikatisetsa kalafo ke kenyelletsa hormone maiketsetso. Ka mafu a mang endocrine kapa mafu a ea tsamaiso ea ho hlahisa bana ha motho a sebelisa lithethefatsi gonadotropins. tsamaiso bona ka tekanyo e itseng ho ama tlhahiso ea li-hormone ho kopanela liphate le ho dithulaganyo etsahalang 'meleng.

Tabeng ea tswakana tsa gonadotrophins ka ntshetsa pele itseng endocrine mafu a (ho ntšoa ha limpa a trimester pele, butsoe ho kopanela liphate, infantilism thobalano, panhypopituitarism le lefu Sheehan e).

Ho loantša pathologies tsena, mali e entsweng ho etsa lipatlisiso le ho hlahloba sebopeho lona hormonal. Ebe prescribers tse hlokahalang ho tsosolosa teka-tekano e loketseng ea li-hormone le Ka hona, molao oa tsamaiso ea dithulaganyo ea bohlokoa 'meleng.