"Fosinopril": litaelo ho sebelisoa. "Fosinopril": bontšang bakeng sa tšebeliso, ba sebele counterparts

"Fosinopril" ke sesitisa tsa angiotensin fetola potlakisang tsebetso ea lik'hemik'hale. moriana o hypotensive bohato, e ka sebelisoa bakeng sa khatello e phahameng ea mali, le mong le ka phekolo e rarahaneng. Ho feta moo, moriana o fana ka natriuretic, vasodilating le bohato cardioprotective, ho e sebediswa hammoho le lithethefatsi tse ling tse nakong ea kalafo ea ha pelo.

Diokobatsi thepa "fosinopril"

Ho lokisetsa "Fosinopril" 'meleng o le sebōpeho sa metabolite mafolofolo nakong eo nyahamisa phello angiotensin fetola potlakisang tsebetso ea lik'hemik'hale. Lithethefatsi ho fokotsa tekanyo ea sebopeho sa angiotensin 2, normalizes khatello systemic mali, phello e ntle ka lijaneng tsa mali.

Angiotensin fetola mosebetsi potlakisang tsebetso ea lik'hemik'hale ho sebedisa 10, 20 le 40 mg, ea lithethefatsi e haholo tsa fokotswa ka karolelano ka lihora tse 7 (ha ho ka potlako ho feta dihora tse 2, empa ha ho ka morao ho lihora tse 12 ka mor'a ho noa meriana e). Nakong ea letsatsi e e fokotsehile ka 7-15%.

"Fosinopril" Tablets lumella ho qhelela ka thōko myocardial hypertrophy le dilation tsa ventricle le letšehali, ka ho ba teng ha maemo a joalo kenya letsoho hore ho ntsha bona. Lithethefatsi thibela sebopeho sa aldosterone eo e phethahatsoa ka ho litsoelesa le adrenal, eketsa mosebetsi oa tsamaiso kallikrein-kinin, tsitsisa le dikahare bradykinin ka lisele le mali. phekolo e loketseng e thehiloeng le tšebeliso ea "fosinopril" eketseha liberatiou dintho tseo ntlafatsa phepelo ea mali ho liphio, na natriuretic, bohato vasorelaxant. The moriana o fokotsa tlhahiso ea arginine vasopressin le endothelin-1, e leng bohato vasoconstrictor.

Ka ho fokotsa khatello ea (diastolic, systolic) ha hlahisa, 'me postural orthostatic tachycardia itšoara joang ha a fetohe BCC. Ha ho na liphetoho tse ka mosebetsi reflex tsa myocardium, renal le bokong phallo ea mali. Ho na le e bile ha ho na tlōlo ea phepelo ea mali ho letlalo, litho tse ka hare, ya marapo mesifa dinama tse nyenyane tse.

E le taeo e pukwanana, "Fosinopril" le sebelisitsoeng ho lethal dose e le 'ngoe, o na le bohato hypotensive e ngata le bitsoa ka mor'a lihora tse ka bang hlano. Phello sephetho le e bolokoa ka letsatsi, e leng lumella u ho boloka le tloaelehileng entsprechen khatello ea mali. Ho bontša ho palo e kahodimodimo khoneha e le hantle e hlokehang ho se ho fetile libeke tse 'maloa.

Nakong ea kalafo "fosinopril" kgatelelo ya madi a ka ntlafatsa e le karabelo ea 'mele ea ho fokotseha ka potlako khatello systemic mali. Ha li kopana phekolo le thiazides le "Fosinopril" le bolela bonahala ho feta phatlalletsoang antihypertensive mosebetsi. Haeba ho hlokahala, hlakola le "fosinopril" ba ne ba sa be le lefu la, ho ke ke ha esita le ka nyeoe e 'ngoe eo ka eona khanselwa ho o entsoe ka tsela e hlollang. Ba lokisetsa ho ntlafatsa le mamello ha thata phallang foromo foleng pelo hloleha, hammoho le e le karabelo ea 'mele ea ho khatello ea kelello' mele.

Mabapi le pontšo ea thepa mutagenic le genotoxic ka nako ya kalafo "Fosinopril" litlhare tataiso bontša sieo tsa bona. Leha ho le joalo, ho sebelisa tekanyetso cytotoxic isang ba bang ba mafu a amanang le aberrations chromosomal. Lithuto ne a khanna ka litoeba le likhoto ile a bontša hore lethal dose ea letsatsi le letsatsi ha feteng 400 mg, / lik'hilograma hase eena ea bakang matšoao a carcinogenicity. Ka lebaka tekanyetso e phahameng ka ho likhoto motona pata lipomas hangata e hlaha. Daily tekanyetso ea moriana ho fihlela ho 60 mg, / lik'hilograma ka likhoto aa ka ae baka mafu a amanang le ho kenya tshebetsong mosebetsi ikatisa. Ha laolwa moriana o likhoto mokhachane (letsatsi le letsatsi lethal dose ho fihlela ho 400 mg, / lik'hilograma ka letsatsi) le mebutlanyana (letsatsi le letsatsi lethal dose 40 mg, / lik'hilograma) hlahile botahoa, ho sebelisa lithethefatsi hampe ama mokhoa oa ho ho ima.

Fire le bolela "Fosinopril" User Kopo tšoauoa ka ea liehang, ka lebaka la ho fokolloa ke lijo tse ngata. Ka lebaka la pele-fetisetsana metabolism bioavailability hanyenyane (36%). "Fosinopril" hydrolyzed, tshebetso ena e hlaha ka mali, sebete le likhetla gastrointestinal ka lebaka la ho kenngwa tshebetsong ha lona fozinoprilat thehoa, e leng metabolite mafolofolo. Boemo lebetsoeng le meriana 'meleng e fumanoa ka karolelano lihora tse tharo ka mor'a hore kopo ya lona. Halofo ea bophelo e hlaha ka lihora tse 12-15. Ho buisana le lero la mali le se hoo e ka bang ka ho feletseng - ho fihlela ho 98%, molumo oa ho aba ke tse nyenyane.

Meriana ha e khahlanong le meeli placental le mali-boko ditshita tse, nako ya kalafo se teng ka lebese. Ka ho thatafala ha sebete (joala, biliary) fokotseha rengwa, hydrolysis o tsoela pele butle-butle. Ka insufficiency renal le hlaha kgoreletsego diatsidnyh a sebetsang a metabolites excretion, lithethefatsi ka 'na ipokellela ka' mele. Tshebediso ya dialysis ho tlosa lithethefatsi ho tswa ho phelang "Fosinopril" taeo pukwanana panyang e le ketso e leng ha e hlahisa sephetho batlang.

Ho bonahala "Fosinopril" ho lokisetsa

"Fosinopril" tseo ke li behetsoeng ha pelo le kgatelelo ya madi. Tabeng ea pele, lithethefatsi ke motheo bakeng sa phekolo eketsehileng, ka e rarahaneng ea bobeli e sebediswa bakeng sa phekolo le monotherapy.

Kalafo le "Fosinopril"

Ka tloaelo ho, ho na le matlapa a ho noa makhetlo a 'ngoe kapa tse peli ka letsatsi ka nako e tšoanang. Ka ho phekola kgatelelo ya madi kgothaletswa pele 10 mg, ea lithethefatsi, 'me hamorao - 20-40 mg,. Ea ho phekola ho kopantswe, haese ha "fosinopril" le sebelisitsoe diuretic, ho nka 10 mg, ea lithethefatsi. Tabeng ena, e tsoelang pele go baya leitlho ea khatello ea mali, ho palo e kahodimodimo khoneha lethal dose ea lithethefatsi ke 80 mg, ka ho ya ka letsatsi. Haeba moriana, lethal dose 'ngoe ha e kopola ne ee lijong. tekanyetso kalafo ya hlahiswa ho sebelisa lisebelisoa kgothaletswa ke ngaka ke ke a nka e kholoanyane kapa nyenyane palo ya lithethefatsi le eketsa maqhubu a lona tsa tšebeliso, leha e le hore phetha khanselwa "fosinopril" ntle le rerisane ngaka.

Pele ho noa meriana le "Fosinopril" pukwanana kgothaletswa hore o leke tekanyo ea ho eketseha ha khatello ea mali. Ka ho kgethwa ha kalafo o nahanela maemo a fapaneng tsa tleleniki, ngaka e lokela ho kamehla hlokomela boemo ba mokuli.

Ho fokotsa kotsi ya ntshetsopele ya kgatelelo ya madi mahareng, e lethal dose nyane khothalletsa a il'o robala. kalafo Antihypertensive hlakola ka matsatsi a supileng pele ho qalo tsa phekolo, "fosinopril". Haeba u ba pele o ile a etsa phekolo diuretic ke ho fokotsa kotsi ea bontshang matshwao hypotension, khalemela mokelikeli le electrolyte ho leka-lekana, diuretic fokotsa lethal dose ya, maemong a mang, khaotsa ho noa lithethefatsi ka ho feletseng (matsatsi a 4-7 pele ho lethal dose ea pele "fosinopril").

Mora myocardial infarction phekolo e bolela "Fosinopril" taeo ka kopo e lumella u ho qala matsatsi a mararo hamorao. Nakong ea kalafo hloka go lekanya kamehla ba khatello ea mali le cheke mekhoa ea mali pheriferale (a hlahloba pele phekolo, laola ka hare ho likhoeli tse 3-6 tsa phekolo ka netefatso ya nakong e tlang o etsoa selemo le selemo, khafetsa boalosi 'na ha hlokahala ha phahameng kgonego ya ketsahalo ea neutropenia). Ho feta moo, ho ke ke ho hlokahala hore ho ho laola boima ba 'mele, hlahloba boemo ba liphio le maemo creatinine, potassium ka ho hlophisoa ha lero la mali protheine, mali urea naetrojene. Nakong ea kalafo u lokela ho latela lijo.

Bakuli bao bolaeang kgatelelo ya madi e na le ditlhaka meriana lethal dose butle-butle e ile ea eketseha (mong le e mong bosiu), nahana ka liphetoho tse ka khatello ea mali, ha e le hantle ho tla meaho.

Contraindications ea ho fumana 'Fosinopril "lithethefatsi

Ha abela matlapa "Fosinopril" ho bonahala lebaka la ho sebelisa li nkoa ka nako le contraindications. moriana e sa sebelisoa tabeng ea hypersensitivity ho metsoako e le hore lithethefatsi tse ling tse tšoanang le eo. Meriana a sa ba laela hore bakuli ba ba lilemo li dilemo tse ka tlase ho 18 ba lilemong tsa ho le basali ba baimana, kanyeso basali. Contraindication e haholo e phallang ho hloleha renal. Contraindications kenyeletsa angioedema (idiopathic, lefa) ka teng ka nako e sa khethoa ha moriana, hammoho le batho ba nang le histori e bontša hyperkalemia, hypotension.

ho ima

Tablets "Fosinopril" taeo pukwanana hanela ho sebelisa nakong ea bokhachane, hobane lithethefatsi tsa mofuta ona ho ka etsa hore mafu a ntshetsopele le lefu fetal.

Ha bokhachane ke nako ya kenngwa tshebetsong ha phekolo e hloka bo felisoe e potlakileng ea moriana. Maemong a joalo, ho ithuta oa ultrasound ho fumana kotsi ho lesea le.

tsoa tsoaloa A eo 'mè oa ileng la le tšoara nakong ea bokhachane "fosinopril", ka fumanoa hyperkalemia, hypotension, oliguria. Haeba pele oliguria, ke habohlokoa ho fana ka tšehetso ho perfusion renal le khatello ea mali a hlahloba kamehla. Haeba mesebetsi e liphio le hore normalize khatello ea mali mogzhet ho phethwa ka tšelo kapa dialysis.

Mefokolo ea ho sebelisoa ha "Fosinopril" ho lokisetsa

Ho hang ba tsoela pele mafu autoimmune lokela ho nahana ka karo-karolelano ea melemo e le likotsi ba kalafo ho bolela "Fosinopril". Litaelo tsa tšebeliso, likarabo tsa bontša bohlokoa ba ho ela hloko likotsi tse le melemo e maemong a latelang:

• gogoga mothapo lefu;
• ho ba teng ha mokuli isoang liphio;
• gout;
• lefu la tsoekere;
• histori angioedema;
• liforomo foleng ba lefu obstructive matšoafo;
• hyperkalemia le index ea moholo ho feta 5.5 go mmol / k;
• desensitization;
• ho thatafala ha sebete;
• obstructive liphetoho, a tsamaea le phytoteratology outflow mali ho tsoa pelong (aortic stenosis, mitral);
• haholo ha pelo;
• lijo, ho fana ka ho noa e lekanyelitsoeng ea dikahare letsoai kapa ea chelete bonyane ba sodium ka lijo chesa;
• hyponatremia;
• leukopenia, thrombocytopenia;
• ba bang ba mekgwa ya tshebetso (dialysis, thethebatso) tshebetsong;
• atherosclerosis, e ama maoto le matsoho ka tlaase;
• dehydration;
• renal ho hloleha creatinine holimo 300 pmol / L;
• botsofali;
• lefu la sebete;
• mathata le boko le gogoga phallo ea mali;
• stenosis;
• maemo a eo ho eona fokotseha BCC.

litla-morao tse ling tsa "Fosinopril" lithethefatsi

Fumaneha ho moriana o "Fosinopril" ulasan pelanggan le tataiso bontša monyetla ea ho tšoaroa ke litla itseng lehlakoreng. Ka 'na etsahala ka mafu a ea tsamaiso hematopoiesis le tsamaiso pelo le methapo. liphetoho khoneha ea tsamaiso ea methapo ea kutlo, tshilong ya dijo tsamaiso, ntshetsopele ya le hlaphohetsoe likelellong tshebetso. Ba bang bakuli ba ne liphetoho entsprechen laboratori ea le liketsahalo tse bohloko, ponahalo ea letlalo amehang, musculoskeletal tsamaiso. Ka 'na la hlaha meferefere tsamaisong ea matšoafo le urogenital. Har'a liphetoho tse ling tse bohloko 'mele - hyperhidrosis, boima ba' mele, ho hlatsa, feberu, angioneurotic edema, ntshetsopele mele dithulaganyo tšoaetsanoang kapa dithulaganyo hlabang ka nodes lisele tsa mmele, lymphadenopathy, a ntseng a mpefala ba gout. mathata leha e le nakong ea kalafo lokela ho ho tlalehoa hore ngaka ea hao. kotsi e phahameng ea liketsahalo tse bohloko tse amanang le tšebeliso e mpe ea lithethefatsi.

Overdose "Fosinopril" lithethefatsi

Ka kalafo lithethefatsi, "Fosinopril" likarabo bontša boteng kgonego ya overdose e ka lebaka la feteng le lethal dose kgothaletswa. Overdose e tsamaea le liponahatso hlobaetsang ea hypotension, renal ho hloleha, stupor, makala, bradycardia, likhathatso tsa metsi le electrolyte ho leka-lekana.

Hlahisa phokotso e lethal dose kapa felisoa ha e moriana o hlatsoa mala le fa mokuli ho noa ka sorbent. Ke habohlokoa hore batho ba nke boemo ba tshekaletseng, ke habohlokoa ho kenya tshebetsong mehato e ikemiseditse ho eketsa BCC. E boetse e hloka phekolo bontshang matshwao. Hemodialysis tabeng ena ha e fane ka phello batlang.

sebelisana lithethefatsi "Fosinopril" ho lokisetsa

Kgonego ya ketsahalo ea hyperkalemia phahameng ka ho fetisisa ha u sebelisa lithethefatsi, e leng se entsoe ka baemeli potassium letsoai, cyclosporine, tlatseletsong le potassium, potassium-o qenehela diuretics.

Phello ea lithethefatsi ho e ba a bontša ka ho hlaka ho feta ka ho sebelisa mekhoa e meng, e na le phello hypotensive, 'me ba noa joala. A phello e fokolang haholo ho feta lebeletsoe se teng ka lebaka la ho sebelisoa ha lintho tse hore ebe o kenya tshebetsong le renin-angiotensin-aldosterone tsamaiso, estrogen bananeng, NSAIDS le sympathomimetics. Maemong a joalo ho ke ke ho hlokahala hore ho hana ho amohela chelete tsena kapa nka sebaka sa "Fosinopril". Analogs ba khethiloeng ke ngaka ho ba teng. Ka monyetla oa ho kopantseng lithethefatsi le lithethefatsi tse ling li ka fumaneha setsebi sa.

Analogs, "Fosinopril" synonymes lithethefatsi

"Fosinopril" o synonymes le analogues. Bakeng sa synonymes e matleng a hae "Fosinopril-Teva", "Monopril." From sehlopha sena lithethefatsi hlahiswa "Fosinopril-OBL», «Fozikard". Ea synonymes le uena u ka khetha "Fozinal", "Fozinotek".

Ha kalafo ha se dumelle ho bolela "Fosinopril" litaelo tsa tšebeliso, synonymes kapa analogs e behiloeng setsebi bakeng sa kalafo. Analogs "Berliprilom ',' Renitec '" ramipril "," Moeksom "," lisinopril ". Tsebahalang analogs hape owns "Prestarium", "Enap" le "enalapril". Ea analogues ka abeloa "Tritatse", "Akkupro", "captopril". Khoneha kalafo sebelisa "Charter" kapa "Prenessa".

Ha e hanela ho sebelisa litlhare "Fosinopril" litaelo tsa tšebeliso, analogs kapa synonymes khetha etsa qeto ea setsebi.

Reviews of ho lokisetsa "Fosinopril"

Ho bohlokoa ho khetha le tokelo ya meriana ho ba le mamello-ba khahlanong le hypertension eo, e kentse e peculiarities ea 'mele oa hae. Ha "Fosinopril" lithethefatsi motho loketse, khatello ea e fokotsehile ka katleho, 'me litla-morao ha li etsahala. Ka ulasan pelanggan, ho na le ke ho tsitsisoa ea khatello ea mali, ntlafatsa bophelo bo botle ba ka kakaretso. Haeba liphetoho tse bohloko tsa 'mele le ho ba hlokomela, ba ile ba ba le maikutlo a, haholo-holo latsoa pherekano, Flushing, khohlela.

Phahameng khatello ea mali ho ka etsa hore le mathata a tebileng tse amanang le ho senya makala a bohlokoa, e le u se hlokang le nako ea ho etsa hore phekolo hlokahala le bala tlhaloso ea meriana "Fosinopril" analogues, ho tloaela lesedi tse ling e metle.