Antiplatelet mahlahana a: lenane la lithethefatsi. Anticoagulants le mahlahana antiplatelet, litšobotsi tse bona

Keketseho ea mali hangata e etsa hore thrombosis, leng isang liphello tse matla, ho akarelletsa le lefu. Pharmacology tsoelo-pele e lumella boloka bophelo ba batho ba bakuli ba mafu a joalo ka lebaka la ho sebelisa phekolo tokiso ka fumana lithethefatsi antiplatelet.

ke eng anticoagulants?

Rheological thepa mali ho otla ka ho leka-lekana pakeng tsa coagulation le anticoagulation tsamaiso ea. Ka ho lula ho leka-lekana sena e le anticoagulant tsa tlhaho ba le seabo antithrombin III le heparin, eo o sebetsang ka ho toba antithrombotic mosebetsi, ke hore, ho thibela sebopeho sa e clot mali. The mochine ea nkang khato ea ho ea ho qetela e amanang ho theha e rarahaneng le antithrombin III, ho fellang ka ho thehoa ha ho antithrombin mafolofolo. O, le eena, a ke le boikarabelo ba ho tlama ho thrombin, etsa hore e be a sa kopanele tšebeletsong - e thusa hore ho thibelo ya thrombus sebopeho. Antithrombin III le eona e nang le thepa ea anticoagulant ke inactivating thrombin Leha ho le joalo, ba itšoara joang tsoela pele butle haholo.

Bokhoni ba heparin ho netefatsa inactivation tsa thrombin itšetlehile ka ka tjhelete e ya antithrombin III maling. phetoho hlokahala lethal dose e hlokahalang e thehiloeng and analysis ena. Hangata e hloka hore ho kgethwa ha lithethefatsi tse peli hang-hang - heparin le antithrombin III, ka litekanyetso li behoa tšoanang ba khethoa ka bomong tsa motho ka mong.

Tlamang ho antithrombin - ha mosebetsi feela ea heparin. Ho phaella moo, o khona ho heletsa fibrin ntle ho kenya letsoho ha plasmin, o bitsoa bao e seng enzymatic lysis. itšoara joang Sena ke sebōpeho sa metsoako le mefuta e fapaneng ya lintho tse biologically mafolofolo, ho akarelletsa le peptides le li-hormone. Har'a lintho tse ling khetholla ho hatelloang ba 'maloa ba enzyme amehang mosebetsing oa ho hlabang (ho fokotsa matla lona), hammoho le ho kenya tshebetsong ya lipoprotein lipase le ho ntlafatsa phallo ea mali ka lijaneng tsa pelo.

ke mahlahana antiplatelet eng?

Litokisetso anticoagulants le mahlahana antiplatelet ba ka katleho a sebelisa ho moriana. lebitso lena o ile a fumana chelete, e leng thibela metsoako e oxyphobe (aggregation) ea lisele tsa mali - lisele tse khubelu tsa mali le liplatelete. The mochine ea nkang khato ea dintho tsena e fapaneng, e leng ile a lumella lihlopha tse 'maloa. Antiplatelet mahlahana, lethathamo le pharaletseng la lithethefatsi tse classified e le latelang.

1. ba khahlanong le lōna k'halsiamo ( "Verapamil").
2. Potlakisang tsebetso ea lik'hemik'hale inhibitors, tse akarelletsang lintho tse hatella cyclooxygenase (acid e acetylsalicylic, "naproxen", "Indomethacin") le adenylate cyclase le phosphodiesterase ( "Ticlopidine", "Pentoxifylline").
3. Lithethefatsi hore susumelletsa sebopeho sa prostacyclin ( "pirazolinov").
4. Prostanoids ( "Prostacyclin" le analogues lona se hlahang ho yona a maiketsetso a).
5. Lithethefatsi hore thibela tebelwa ya dintho tse liplatelete ( "Pyracetam").

ya litatoli na

Antiplatelet lithethefatsi - lithethefatsi bao mabitso li tsejoa ho batho ba bangata ka lebaka la ho ya kopo ka bophara. Mosebetsi o ka sehloohong oa sehlopha sena - tsa prophylaxis thrombosis. Antiplatelet lithethefatsi - lithethefatsi tse ka katleho sebetsa a 'maloa a pathologies la pelo, hammoho le mora ho buuoa (di-valve prosthetic pelo).

Antiplatelet mahlahana a: lenane la lithethefatsi tse atisa ho sebelisoa ka go ikatisetsa ya kalafi

Lithethefatsi hore ho matleng a sehlopha sena, haholo tse ngata, 'me kaofela ba ile ba ba le peculiarities ea bona. Kgetho ya ea lithethefatsi ka ho itšetlehile ka ha e ea tleleniki. Le, ya e le hantle, ba ikhopolang ho meriana ka ba boemong bona e sa lokelang.

"Aspirini"

Ka molao oa tsamaiso ea eicosanoids hemostasis tse amehang tabeng ea ho tse sehlahisoa sa ho kena moea oa asiti arachidonic. Har'a bohlokoa ka ho fetisisa tsa thromboxane A2, 'me mosebetsi-holo - ho etsa bonnete ba platelet aggregation. Ketso ea aspirini e tobisitsoe ho thibelo ya potlakisang tsebetso ea lik'hemik'hale e bitsoang cyclooxygenase. Ka lebaka la tswakana ena e hatella tomboksana A2 hona thibang thrombus dithulaganyo sebopeho. phello ea ho eketsa ha boela etellang lithethefatsi ka lebaka la ho bokella. Bakeng sa thibelo tse feletseng tsa cyclooxygenase hlokahala noa letsatsi le letsatsi. The litekanyetso li behoa Optimum fokotsa monyetla oa litla-morao, "aspirini" esita le ka sebelisoa ka linako tsohle. Lethal dose escalation ke e sa amoheleheng, kaha ho na le kotsi ya mathata a tsoa mali.

"Ticlopidine"

lithethefatsi li thehiloe thibela receptors itseng hore ba na le boikarabelo clots mali. Ka tloaelo, ha o amahanya ho bona ho na le ke phetoho ea ADP platelet aggregation susumelletseha le bopehileng, 'me "Ticlopidine" thibela sena. Tšobotsi e 'ngoe ea ho moemeli antiplatelet ke bioavailability phahameng, eo e finyelloa ka phahameng lebelo fire. Ka mor'a ho hlakola e le hantle e hlokomela esita le bakeng sa matsatsi a 3-5. The drawback ke palo e khōlō ea litla-morao, ho akarelletsa le ho nyekoa ke pelo tloaelehileng, letšollo, khaello ea mali le agranulocytosis.

"Clopidogrel"

mahlahana Antiplatelet ho ea ka mofuta oa ketso e tšoanang le ea "ticlopidine", empa molemo lona ke batlang e le e tlase toxicity. Ho phaella moo, kotsi ea litla-morao ha noa lithethefatsi ena ke ka tlaase haholo. Hona joale ho ditsebi fa ratang ho "clopidogrel" ka lebaka la ho ba sieo ha le mathata a kang agranulocytosis le thrombocytopenia.

"Eptifibatide"

Lithethefatsi fana aggregation ke thibela e glycoprotein, eo e teng ka lera platelet. Abeloa ho bolus intravenous, hangata ka angina le angioplasty ho fokotsa monyetla oa infarction myocardial.

"Dipyridamole"

Phello e khōlō ea lithethefatsi - itšetlehileng ka vasodilatation, ke hore, katoloso ea methapo ea mali, empa a bolela antiplatelet le phello e hlokometse ha ho kopantswe le lithethefatsi tse ling. "Dipyridamole" a lokisetsa le "aspirini", haeba ho na le ke kotsing e khōlō ea clots mali. Hape, hoa khoneha ho kopana le "warfarin", hore e ka tsela e atlehang sebelisoa ka mor'a hore ho belofo prosthetic pelo ho fokotsa monyetla oa embolisms. Ka monotherapy e le hantle e tlase phatlalatsoe.

Antiplatelet lithethefatsi - lithethefatsi (lethathamo: "Elikvis", "clopidogrel" le ba bang), ho pharaletseng sebelisoa ka mokhoa ona.

Contraindications

Kgethwa ha phekolo antiplatelet hloka histori hloko, e kenyeletsang tlhahisoleseding e mabapi le comorbidity. Ka ho ba teng ha lefu le hore ke contraindication ho amohela lithethefatsi le sehlopheng sena, ka khalemelo ea morero oa kalafo. Maemong a joalo, e le kgetho ya lithethefatsi ka bomong le dosages bona, 'me kalafo o etsoang tsoa ka tlas'a tlhokomelo ea ka thata-thata ea meriana. Tabeng se tla kopano ikemetseng tsa mahlahana antiplatelet, hobane liphello tsa seo e ka ba kotsi.

Lenane la contraindications:

• kulisoa;
• hemorrhagic diathesis;
• kotsi ea mali;
• haholo sebete le liphio insufficiency;
• histori ea arrhythmia;
• kgatelelo ya madi, haholo;
• mafu obstructive ea tsamaiso ea matšoafo;
• lilemo tsa bana (bakeng sa lihlahisoa tse ngata).

Ho phaella moo, ba bangata ba mahlahana antiplatelet (lenane la lihlahisoa hlahlojoa sehloohong sena) di contraindicated nakong ea bokhachane le ho diabolololo. Nakong ena, e lokela ho ba rata lithethefatsi tse sireletsehileng bakeng sa ngoana le ho 'mè oa.

Antiplatelet mahlahana. Lithethefatsi: lethathamo la ho ima

Haeba o khahlanong le fetal ajoa kotsi ea ho ntša mpa. ketsahalo ena e bitsoa fetoplacental insufficiency. Haeba o khahlanong le pelehi oksijene ho mali a lesea tse tsoelang pele hypoxia haholo, e leng se sokela ha feela le diphapano ka ntshetsopeleng lona, empa hape lefu. Ha diagnosing ya bolwetse hloka kalafo e potlakileng, eo na le ho ntlafatsa phallo ea mali, ho fokotsa mali e tiileng e qamathelang. Etsoe sena le ba khethiloeng mahlahana antiplatelet Leha ho le joalo, ho hlokomela hore ha ho lithethefatsi tsohle sehlopheng sena ba bolokehile nakong ea bokhachane. Khoneha ho sebelisa feela ba bang ba chelete ena.

"Kurantil"

Lithethefatsi ke e ratoa haholo ke e loketseng e le hantle hore ka lethathamo lona tsa contraindications ha ho ima le kanyeso. Active motsoako "chimes" - pele e neng e hlalosoa e dipyridamole, eo dilates methapo ea mali le ho thibela thrombus sebopeho. Ho ntlafatsa myocardial phallo ea mali, ho etsa bonnete ba ho fana ka puo ea ka tjhelete e hlokahalang ea oksijene. Ka tsela ena, K "Urantia" li ka sebelisoa ka ho ba teng ha lefu la pelo ka basali ba baimana. Leha ho le joalo, e le pontšo ka sehloohong la mokhachane ke placentofetal hloleha. Ka ho ntlafatsa thepa rheological mali le vasodilatation, thibelo clogging lijana tsa placenta ho, kahoo, lesea ha le bothata ba ho hypoxia. A Molemo ka ho eketsehileng moriana ka bitsoa e le hantle immunomodulating. Lithethefatsi di hlohleletsago tlhahiso ea interferon, ka tsela eo fokotsa kotsi ea mafu a bongata ba kokwanahloko e 'mè. Leha "Kurantil" 'me e ka sebelisoa nakong ea bokhachane le ho diabolololo, empa ba lokela ho feela ho laela e ha o ile a bontša. Ha a ntse a ho nka lithethefatsi lokela ho fokotsa tshebediso ya tee le kofi ha ba ntse ba fokotseha katleho lona. Antiplatelet lithethefatsi - lithethefatsi (lethathamo ka holimo) hore ha ea lokela ho ho kopantswe le senoa-mapholi tse joalo. Leha ho ima ha a eletsa ba ho fumana ka setotsoana tsela efe kapa efe.

mahlahana Antiplatelet, lethathamo la lithethefatsi e kenyeletsang e mengata e le mabitso, li sebelisoa ka tsela e atlehang ea ho phekola mafu a ea tsamaiso ea pelo le methapo. Leha ho le joalo, ho hlokomela mathata a ho khoneha amanang le fokotseha mali e tiileng e qamathelang le hoama thibelo. Antiplatelet lithethefatsi - lithethefatsi hore li ka sebelisoa feela tlas'a bookameli ba ngaka e-ba teng, o tla lata le litekanyetso li behoa hlokahala le 'nete hore ea phekolo.