Antidepressant 'Azafen', litaelo tsa tšebeliso, litla-morao

Lithethefatsi "Azafen" le bolela sehlopha sa ho antidepressants tricyclic. E na le sedative phahameng, anxiolytic le litla antiaggressive. lithethefatsi hona ho pharaletseng sebediswa bakeng sa kalafo ya a matsoafo a le depressions mahareng, tse kang:

- e se nang sesosa;

- astenodepressiya;

- exogenous;

- joala;

- alamo;

- boemo nakong maemo a somatic ea tlhaho le sa foleng.

The a sebetsang a motsoako oa lithethefatsi "Azafen" Tlhaloso e bua pipofezine. The mochine ea nkang khato ea ho ntho e thehiloeng thibelo ea neuronal uptake tsa norepinephrine le serotonin. Sena se etsa hore ho eketseha ha ea mahloriso ea pipofezine ka CNS le matšoao a tepelletsang cropped.

Ho na le Molemo 'ngoe holim'a lithethefatsi ka tsela e tšoanang antidepressant lithethefatsi bohato "Azafen" litaelo bakeng sa ho sebelisoa e bua ka ho ba sieo ha liphello tsa eona cardiotoxic. E o ile a hlokomela e le tšusumetso e ntle le bolela "Azafen" ka mafu a afeketifi, fokolisa mafu a sa somatic, senohi le autonomic amanang le ho tepella maikutlo. Phahameng bohlokwa ba tsamaiso "Azafen" taeo pukwanana hlalosa khahlanong asthenia, mathata a hlahang ka lebaka la ho e tlameletswe dikelellong somatic batho. Nakong ea tsamaiso ea lithethefatsi bakuli disappears ho tšoenyeha, ho imeloa kelellong. dipharologanyo ntle bakuli ba ho ipolaisa tlala nervosa, ho robala tloaelehileng 'me boroko disappears motšehare.

Medicine "Azafen", e thehiloeng thepa bona pharmacokinetic na digestibility molemo, e hantle ananelang ka pampitšana tshilong ya dijo, o na phahameng bioavailability (80%), palo e kahodimodimo ea mali mahloriso fihla se ka hare ho lihora tse 2. Ka sebete le hlaha ka biotransformation pipofezine ho khathetseng moeeng metabolites hore ba bonahatsa liphio. Feletseng lokolloa ha lithethefatsi ho 'mele ho etsahala ka hare ho lihora tse 16.

Phekolo ea ho tepella maikutlo ea tšimoloho e sa tšoaneng ke pontšo e ka sehloohong bakeng sa tshebediso ya bukana lithethefatsi "Azafen" taeo e totobatsa mmuso, ho thathamisa tsohle mefuta depressioy, o ile a pepesa ho lithethefatsi.

Ho na le contraindications 'maloa bakeng sa kamohelo antidepressant "Azafen" litaelo bakeng sa ho sebelisoa ho bontša e bolela latelang ha li lumellana le kalafo lithethefatsi:

- lefu la tsoekere;

- ho arolelana le Mao inhibitors ;

- myocardial infarction, pelo ea hloleha, gogoga mothapo lefu;

- e amanang le sebete le ho hloleheng renal;

- mafu a tšoaetsanoang, haholo;

- boemo ka mor'a likotsi tse batlang li tebile cerebrovascular (leqeba);

- Boimana, diabolololo.

E lokela itebela e ketsahalo khoneha tsa litla-morao ka nako kalafo, ba bolela hore ke ho tsekela 'me hlooho e opang, kulisa, ho hlatsa le ho nyekoa ke pelo. Ka bomalimabe, ho na le ho na tlhahisoleseding e mabapi le phekolo eo tabeng ea overdose ea lithethefatsi, maemong a joalo, ho hlokahala bontshang matshwao. Tabeng ea ho contraindications lokela ho a phaella ka ho bothata tšoanang oa "Azafen" le joala. Tsena tse pedi bopa dikgopolo tsa ho feletseng bona baa bo khethehileng ka nako kalafo lokela ho khaotsa ho noa lino tse tahang le baeti ba fihlelang ho tsoa hong ea litokisetso nang ethanol.

The "azafen" ha le a fumanwa thepa anticholinergic, kahoo u se ke ua tela kalafo lithethefatsi bakeng sa bakuli ba le glaucoma. Ho feta moo lumellane le joala, ho na le ke kotsi ya kopo tsoa hong ea lithethefatsi le anticoagulants, antihistamines le lithethefatsi tsohle, CNS depressants. Ka kopo ho hlokomela hore tsoa hong baeti ba fihlelang ho ba "azafen" le lithethefatsi antiepileptic fokotsa katleho ya bobeli.

Lokolloa "Azafen" tieo ho latela risepe, e leng palo e kahodimodimo raka, athe bophelo ke lilemo tse 5, e lokela ho bolokoa ka tmax 25.